Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSK21_HUMAN
Description:casein kinase 2, alpha 1 polypeptide [Source:HGNC Symbol;Acc:2457]
Location:chr20 p13
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y255GTEDLyDYIDKLynphosphoELM; RegPhos
Y255GTEDLyDYIDKFgrphosphoELM; RegPhos
S7SGPVPsRARVYPhosphoSitePlus
S370GPLAGsPVIAACDC2(CDK1RegPhos
T344MPGGStPVSSACDK1HPRD; phosphoELM
S362SVPTPsPLGPLPhosphoSitePlus
T344MPGGStPVSSACDK_groupphosphoELM; RegPhos
T360ISSVPtPSPLGCDK1HPRD; phosphoELM
T360ISSVPtPSPLGCDC2(CDK1RegPhos
S207SMPGGsTPVSSHPRD
S226SVPTPsPLGPLCDK1HPRD
S370GPLAGsPVIAACDK1HPRD; phosphoELM
Y46GLAEFyHPGQEHPRD
S217SANMMsGISSVHPRD
T208MPGGStPVSSACDK1HPRD
S234GPLAGsPVIAACDK1HPRD
T360ISSVPtPSPLGPhosphoSitePlus
S362SVPTPsPLGPLCDK1HPRD; phosphoELM
S58NVRVAsRYFKGHPRD
T360ISSVPtPSPLGCDK_groupphosphoELM; RegPhos
S343SMPGGsTPVSSHPRD
S194NVRVAsRYFKGHPRD
Y239HGHDNyDQLVRPkinasePhosphoSitePlus
S287ERFVHsENQHLPkinasePhosphoSitePlus
S353SANMMsGISSVHPRD
T344MPGGStPVSSACDC2(CDK1RegPhos
S194NVRVAsRYFKGPkinasePhosphoSitePlus
S370GPLAGsPVIAAPhosphoSitePlus
S362SVPTPsPLGPLCDK_groupphosphoELM; RegPhos
T224ISSVPtPSPLGCDK1HPRD
T344MPGGStPVSSAPhosphoSitePlus
S362SVPTPsPLGPLCDC2(CDK1RegPhos
S356MMSGIsSVPTPHPRD
S2____MsGPVPSPhosphoSitePlus
Y182GLAEFyHPGQEHPRD; RegPhos
T127KQLYQtLTDYDPkinasePhosphoSitePlus
S362SVPTPsPLGPLCDC2RegPhos
S2PVPSHPRD
T344MPGGStPVSSACDC2RegPhos
T360ISSVPtPSPLGCDC2RegPhos
Y50LGRGKySEVFEPkinasePhosphoSitePlus
S370GPLAGsPVIAACDC2RegPhos
S220MMSGIsSVPTPHPRD
S277ILGRHsRKRWEPkinasePhosphoSitePlus
Y182GLAEFyHPGQEPkinasePhosphoSitePlus
Y255GTEDLyDYIDKPkinasePhosphoSitePlus
S370GPLAGsPVIAACDK_groupphosphoELM; RegPhos

Dephosphorylation site
CSK21_HUMAN do not have dephosphorylation site.

Mutation site
CSK21_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000217244Breast CancerNormal vs. CancertissueUp0.4420739354

Hyperphosphorylation site
CSK21_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANPACS1_HUMANkinase -> substrateHPRD
CSK21_HUMANP53_HUMANkinase -> substrateHPRD
CSK21_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCLCB_HUMANkinase -> substrateHPRD
CSK21_HUMANVDR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANTF65_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
CSK21_HUMANFA5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANIPP2_HUMANkinase -> substrateHPRD
CSK21_HUMANKIF1C_HUMANkinase -> substrateHPRD
CSK21_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPP1R8_HUMANkinase -> substrateHPRD
CSK21_HUMANATF1_HUMANkinase -> substrateHPRD
CSK21_HUMANUB2R2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANPTEN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANRMI1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANEGR1_HUMANkinase -> substrateHPRD
CSK21_HUMANMAX_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANZRAB2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMAZ_HUMANkinase -> substrateHPRD
CSK21_HUMANABCA1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANTFPI1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANARNT_HUMANkinase -> substrateHPRD
CSK21_HUMANVMAT2_HUMANkinase -> substrateHPRD
CSK21_HUMANTLE1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPRGR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANPSA3_HUMANkinase -> substrateHPRD
CSK21_HUMANGEMI7_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMAN4EBP1_HUMANkinase -> substrateHPRD
CSK21_HUMANXRCC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANRBX2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHDAC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANPTPRC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANSPTB2_HUMANkinase -> substrateHPRD
CSK21_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANJUN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANZCRB1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCSK21_HUMANkinase -> substrateRegPhos
CSK21_HUMANACACA_HUMANkinase -> substrateHPRD
CSK21_HUMANHIF1A_HUMANkinase -> substrateHPRD
CSK21_HUMANNUAK1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCTNB1_HUMANkinase -> substrateHPRD
CSK21_HUMANCDN1B_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANEXOS7_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHES6_HUMANkinase -> substrateHPRD
CSK21_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPPR1B_HUMANkinase -> substrateHPRD
CSK21_HUMANSTC2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANTAF5L_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMPIP2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANIF5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANMYB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANNOL3_HUMANkinase -> substrateHPRD
CSK21_HUMANFKBP4_HUMANkinase -> substrateHPRD
CSK21_HUMANTF2AA_HUMANkinase -> substrateHPRD
CSK21_HUMANIBP3_HUMANkinase -> substrateHPRD
CSK21_HUMANHXB7_HUMANkinase -> substrateHPRD
CSK21_HUMANRMP_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPTN1_HUMANkinase -> substrateHPRD
CSK21_HUMANHDAC3_HUMANkinase -> substrateHPRD
CSK21_HUMANNUP62_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPIN4_HUMANkinase -> substrateHPRD
CSK21_HUMANEF1B_HUMANkinase -> substrateHPRD
CSK21_HUMANM4K2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMK09_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHIRP3_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSSRP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANSYUA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANRAD_HUMANkinase -> substrateHPRD
CSK21_HUMANROA1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANOCLN_HUMANkinase -> substrateKEGG
CSK21_HUMANC1R_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANTOP2A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANERH_HUMANkinase -> substrateHPRD
CSK21_HUMANDDIT3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHNRPC_HUMANkinase -> substrateHPRD
CSK21_HUMANLRIG1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANBCR_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHS90A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANIF2B_HUMANkinase -> substrateHPRD
CSK21_HUMANMEF2C_HUMANkinase -> substrateHPRD
CSK21_HUMANG6PI_HUMANkinase -> substrateHPRD
CSK21_HUMANHMGA1_HUMANkinase -> substrateHPRD
CSK21_HUMANLEG3_HUMANkinase -> substrateHPRD
CSK21_HUMANRNPS1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCREM_HUMANkinase -> substrateHPRD
CSK21_HUMANEI2BE_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANANM6_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANCSK21_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANIL16_HUMANkinase -> substrateHPRD
CSK21_HUMANVTNC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
FGR_HUMANCSK21_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCDK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANUB2R1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCASQ2_HUMANkinase -> substrateHPRD
CSK21_HUMANIKBA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANUTP18_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANTSPY1_HUMANkinase -> substrateHPRD
CSK21_HUMANGMFB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANHCLS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANFAF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANSPF45_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSRPK1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCAV1_HUMANkinase -> substrateHPRD
CSK21_HUMANTEBP_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANJAM1_HUMANkinase -> substrateHPRD
CSK21_HUMANAKT1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSP1_HUMANkinase -> substrateHPRD
CSK21_HUMANRGS19_HUMANkinase -> substrateHPRD
CSK21_HUMANPI42A_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSRF_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANIRS1_HUMANkinase -> substrateHPRD
CSK21_HUMANGBRR1_HUMANkinase -> substrateHPRD
CSK21_HUMANMYCN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANPSN2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANERCC3_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANTF7L2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPKD2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANCDC37_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANBRCA1_HUMANkinase -> substrateHPRD
CSK21_HUMANHS90B_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANEPHA3_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSAT1_HUMANkinase -> substrateHPRD
CSK21_HUMANVCAM1_HUMANkinase -> substrateHPRD
CSK21_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANASIC3_HUMANkinase -> substrateHPRD
CSK21_HUMANZN765_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANPGM1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANIF16_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANWASP_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANHDAC2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANHS105_HUMANkinase -> substrateHPRD
CSK21_HUMANAKIP_HUMANkinase -> substrateHPRD
CSK21_HUMANARRB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANAPEX1_HUMANkinase -> substrateHPRD
CSK21_HUMANHMOX2_HUMANkinase -> substrateHPRD
CSK21_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANOSTP_HUMANkinase -> substrateHPRD
CSK21_HUMANSTX1A_HUMANkinase -> substrateHPRD
CSK21_HUMANTF2AY_HUMANkinase -> substrateHPRD
CSK21_HUMANMEF2A_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMPRI_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANLA_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANFZR_HUMANkinase -> substrateHPRD
CSK21_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANBIK_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMYC_HUMANkinase -> substrateHPRD
CSK21_HUMANMYF6_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSHOX_HUMANkinase -> substrateHPRD
CDK1_HUMANCSK21_HUMANkinase -> substrateRegPhos
CSK21_HUMANCD20_HUMANkinase -> substrateHPRD
CSK21_HUMANVAMP4_HUMANkinase -> substrateHPRD
CSK21_HUMANNKX25_HUMANkinase -> substrateHPRD
CSK21_HUMANMYF5_HUMANkinase -> substrateHPRD
CSK21_HUMANPHAX_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANAQP4_HUMANkinase -> substrateHPRD
CSK21_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANZN223_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANEI2BA_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANGYS1_HUMANkinase -> substrateHPRD
CSK21_HUMANSTMN1_HUMANkinase -> substrateHPRD
CSK21_HUMANRAGP1_HUMANkinase -> substrateHPRD
CSK21_HUMANBID_HUMANkinase -> substrateHPRD
CSK21_HUMANCD5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANNEUM_HUMANkinase -> substrateHPRD
CSK21_HUMANSPIB_HUMANkinase -> substrateHPRD
CSK21_HUMANHSF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANTCP4_HUMANkinase -> substrateHPRD
CSK21_HUMANCTDP1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction
hsa03008Ribosome biogenesis in eukaryotes
hsa05168Herpes simplex infection
hsa04064NF-kappa B signaling pathway
hsa05162Measles
hsa04310Wnt signaling pathway
hsa05169Epstein-Barr virus infection
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0019888protein phosphatase regulator activityIEAmolecular_function
GO:0061077chaperone-mediated protein foldingTASbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0031519PcG protein complexIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0051879Hsp90 protein bindingTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016581NuRD complexIDAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0071174mitotic cell cycle spindle checkpointIMPbiological_process
GO:0016580Sin3 complexIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function