Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF4B_HUMAN
Description:eukaryotic translation initiation factor 4B [Source:HGNC Symbol;Acc:3285]
Location:chr12 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y224SFGDKyRDRYDPhosphoSitePlus
Y302RYEDRyDRRDDPhosphoSitePlus
T461DCHSPtSKPPKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T18KTISLtDFLAEHPRD
T205RARPAtDSFDDPhosphoSitePlus
S488AWVKRsSNPPAPhosphoSitePlus
Y237RYRDGyRDGYRPhosphoSitePlus
S422RSRTGsESSQTp70S6KphosphoELM; RegPhos
T431QTGTStTSSRNPhosphoSitePlus
T450SLENEtLNKEEHPRD
S352SSASTsQSTRAPhosphoSitePlus
Y291RRDDDyRGGGDPhosphoSitePlus
T427SESSQtGTSTTPhosphoSitePlus
T75RSILPtAPRAAPhosphoSitePlus; HPRD
S131LPREPsNPERLRRM_1PhosphoSitePlus
S424RTGSEsSQTGTPhosphoSitePlus
S219RRGDDsFGDKYPhosphoSitePlus; HPRD; phosphoELM
S111DVTEEsIKEFFRRM_1PhosphoSitePlus
S406RERHPsWRSEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S131LPREPsNPERLHPRD
S489WVKRSsNPPARPhosphoSitePlus; HPRD
T506EQQSPtSGGGKPhosphoSitePlus
S498ARSQSsDTEQQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T420RERSRtGSESSPhosphoSitePlus; HPRD
T195RDSDKtDTDWRPhosphoSitePlus; HPRD
Y211DSFDDyPPRRGPhosphoSitePlus; HPRD; SysPTM
S504DTEQQsPTSGGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S263YDDRGsRDYDRPhosphoSitePlus
Y241GYRDGyRDGPRPhosphoSitePlus
S442ARRREsEKSLEPhosphoSitePlus; HPRD
S155LLSALsLNEESHPRD
S309RRDDRsWSSRDPhosphoSitePlus
S430SQTGTsTTSSRPhosphoSitePlus
T197SDKTDtDWRARPhosphoSitePlus
S433GTSTTsSRNARPhosphoSitePlus
T341LKPRStPKEDDPhosphoSitePlus
S35GSTYVsKPVSWHPRD
Y321YSRDDyRRDDRPhosphoSitePlus
Y298GGGDRyEDRYDPhosphoSitePlus
S359STRAAsIFGGAPhosphoSitePlus; HPRD
Y258GGRDRyDDRGSPhosphoSitePlus
Y33GGGSTyVSKPVPhosphoSitePlus
S422RSRTGsESSQTPhosphoSitePlus; phosphoELM; RegPhos
T429SSQTGtSTTSSPhosphoSitePlus
Y316SSRDDySRDDYPhosphoSitePlus
S597KYAALsVDGEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S283RRAFGsGYRRDPhosphoSitePlus; HPRD; phosphoELM
S311DDRSWsSRDDYPhosphoSitePlus; HPRD
S160SLNEEsLGNRRHPRD
S347PKEDDsSASTSPhosphoSitePlus
S462CHSPTsKPPKPPhosphoSitePlus; HPRD; phosphoELM
S497PARSQsSDTEQPhosphoSitePlus; HPRD; phosphoELM
Y270DYDRGyDSRIGPhosphoSitePlus
S445RESEKsLENETPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y266RGSRDyDRGYDPhosphoSitePlus
S16KGKTIsLTDFLPhosphoSitePlus; HPRD
S507QQSPTsGGGKVHPRD
S93SRLPKsPPYTAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y609NEGEDyAE___PhosphoSitePlus
Y96PKSPPyTAFLGPhosphoSitePlus; HPRD; phosphoELM
Y105LGNLPyDVTEERRM_1PhosphoSitePlus
T351DSSAStSQSTRPhosphoSitePlus
S425TGSESsQTGTSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S183DRDDRsFGRDRPhosphoSitePlus; HPRD
S340NLKPRsTPKEDPhosphoSitePlus; HPRD
T500SQSSDtEQQSPPhosphoSitePlus; HPRD; phosphoELM
S418QERERsRTGSEPhosphoSitePlus
Y63NDDDVyRAPPIPhosphoSitePlus
T432TGTSTtSSRNAPhosphoSitePlus
S591KFSSAsKYAALPhosphoSitePlus
S57STTWHsNDDDVPhosphoSitePlus
S207RPATDsFDDYPPhosphoSitePlus; HPRD
S409HPSWRsEETQEPhosphoSitePlus; HPRD; SysPTM
T32TGGGStYVSKPHPRD
Y593SSASKyAALSVPhosphoSitePlus
S312DRSWSsRDDYSPhosphoSitePlus
T412WRSEEtQERERPhosphoSitePlus; HPRD
Y141LKGFGyAEFEDRRM_1PhosphoSitePlus
S230RDRYDsDRYRDPhosphoSitePlus
S39VSKPVsWADETPhosphoSitePlus
S350DDSSAsTSQSTPhosphoSitePlus
S422RSRTGsESSQTRPS6KB1HPRD
T369AKPVDtAARERPhosphoSitePlus; HPRD
T14NKKGKtISLTDHPRD
T27AEDGGtGGGSTHPRD
Y285AFGSGyRRDDDPhosphoSitePlus; HPRD; phosphoELM
S459EEDCHsPTSKPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S348KEDDSsASTSQPhosphoSitePlus
S192DRNRDsDKTDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y228KYRDRyDSDRYPhosphoSitePlus
S495NPPARsQSSDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T97KSPPYtAFLGNPhosphoSitePlus
S71PPIDRsILPTAHPRD
S272DRGYDsRIGSGPhosphoSitePlus
Y252RDMDRyGGRDRPhosphoSitePlus
S434TSTTSsRNARRPhosphoSitePlus
S317SRDDYsRDDYRPhosphoSitePlus

Dephosphorylation site
IF4B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262056E114*BIOMARTBreast Cancer21930507, 21930502
ENSP00000262056W484LCOSMICHead and Neck Cancer21798893
ENSP00000262056P203RCOSMICRenal Cancer21248752
ENSP00000262056D324NCOSMICBreast Cancer17932254
ENSP00000262056E109KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262056Breast CancerNormal vs. Cancercell lineUp1.420543960

Hyperphosphorylation site
IF4B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANIF4B_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
CDK7_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANIF4B_HUMANkinase -> substrateRegPhos
FYN_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
ST38L_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0000288nuclear-transcribed mRNA catabolic process, deadenTASbiological_process
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0016070RNA metabolic processTASbiological_process
GO:0006412translationTASbiological_process
GO:0006413translational initiationTASbiological_process
GO:0006446regulation of translational initiationTASbiological_process
GO:0016281eukaryotic translation initiation factor 4F compleTAScellular_component
GO:0003723RNA bindingTASmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0005829cytosolTAScellular_component


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