Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PSN2_HUMAN
Description:presenilin 2 (Alzheimer disease 4) [Source:HGNC Symbol;Acc:9509]
Location:chr1 q42.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S9FMASDsEEEVCCK1aRegPhos
S9FMASDsEEEVCCSNK1DHPRD
S330EDSYDsFGEPSCK2a1(CK2 alphaRegPhos
S7LTFMAsDSEEECK1_groupRegPhos
S19CDERTsLMSAECSNK1DHPRD
S327EMEEDsYDSFGCK1d(CK1 deltaRegPhos
S335SFGEPsYPEVFCSNK1DHPRD
S330EDSYDsFGEPSCK1dRegPhos
S327EMEEDsYDSFGCK1dRegPhos
S19CDERTsLMSAECSNK1A1HPRD
S7SEEECSNK2A1HPRD
S7SEEECSNK1DHPRD
S335SFGEPsYPEVFCK2a1(CK2 alphaRegPhos
S334SFGEPsYPEVFCSNK1DHPRD
S19CDERTsLMSAECK2_groupphosphoELM; RegPhos
S9FMASDsEEEVCPhosphoSitePlus
S335SFGEPsYPEVFCSNK2A1HPRD
S335SFGEPsYPEVFCK2_alphaphosphoELM
S9FMASDsEEEVCCK1_groupphosphoELM; RegPhos
S7LTFMAsDSEEECK1aRegPhos
S330EDSYDsFGEPSCK1_deltaphosphoELM
S19CDERTsLMSAECK1dRegPhos
S327EMEEDsYDSFGphosphoELM
S335SFGEPsYPEVFCK2a1-rsRegPhos
S330EDSYDsFGEPSCK2_alphaphosphoELM
Y294FPALIySSAMVPresenilinPhosphoSitePlus
S334SFGEPsYPEVFCSNK2A1HPRD
S9FMASDsEEEVCCSNK1A1HPRD
S9FMASDsEEEVCCSNK2A1HPRD
S19CDERTsLMSAECSNK2A1HPRD
S329EDSYDsFGEPSCSNK2A1HPRD
S330EDSYDsFGEPSCK2a1-rsRegPhos
S335SFGEPsYPEVFCK2_groupphosphoELM; RegPhos
S7SEEECK2_alphaphosphoELM
S327EMEEDsYDSFGCSNK1DHPRD
S19CDERTsLMSAEPhosphoSitePlus
S7SEEECK2_groupphosphoELM
S330EDSYDsFGEPSphosphoELM
T27SAESPtPRSCQPhosphoSitePlus; HPRD
S19CDERTsLMSAECK2a1RegPhos
S19CDERTsLMSAECK2a1-rsRegPhos
S22RTSLMsAESPTPhosphoSitePlus; HPRD
S327EMEEDsYDSFGCK1_deltaphosphoELM
S19CDERTsLMSAECK1aRegPhos
S9FMASDsEEEVCCK2_groupphosphoELM; RegPhos
S9FMASDsEEEVCCK1dRegPhos
S335SFGEPsYPEVFCK2a1RegPhos
S7LTFMAsDSEEEPhosphoSitePlus
S335SFGEPsYPEVFCK1dRegPhos
S7LTFMAsDSEEECK1dRegPhos
S330EDSYDsFGEPSPresenilinPhosphoSitePlus
S7SEEECK1_groupphosphoELM
S9FMASDsEEEVCCK2_alphaphosphoELM
S329EDSYDsFGEPSCSNK1DHPRD
S7SEEECSNK1A1HPRD
S330EDSYDsFGEPSCSNK1DHPRD
S330EDSYDsFGEPSCK1d(CK1 deltaRegPhos
S7LTFMAsDSEEECK2_groupRegPhos
S25LMSAEsPTPRSPhosphoSitePlus; HPRD; phosphoELM
S7LTFMAsDSEEECK2a1(CK2 alphaRegPhos
S9FMASDsEEEVCCK2a1RegPhos
S9FMASDsEEEVCCK2a1(CK2 alphaRegPhos
S7LTFMAsDSEEECK2a1-rsRegPhos
S335SFGEPsYPEVFPresenilinPhosphoSitePlus
S330EDSYDsFGEPSCSNK2A1HPRD
S9FMASDsEEEVCCK2a1-rsRegPhos
S19CDERTsLMSAECK1_groupphosphoELM; RegPhos
S7LTFMAsDSEEECK2a1RegPhos
S330EDSYDsFGEPSCK2a1RegPhos
S327EMEEDsYDSFGPresenilinPhosphoSitePlus

Dephosphorylation site
PSN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355747A377VCOSMICLung Cancer20668451
ENSP00000355747S176LCOSMICLung Cancer20668451

Differential expressed protein
PSN2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PSN2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1D_HUMANPSN2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANPSN2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1A_HUMANPSN2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04330Notch signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030426growth coneIBAcellular_component
GO:0048538thymus developmentIEAbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0009986cell surfaceIBAcellular_component
GO:0005637nuclear inner membraneIDAcellular_component
GO:0030018Z discIEAcellular_component
GO:0005938cell cortexIBAcellular_component
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0045121membrane raftIBAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0007176regulation of epidermal growth factor-activated reIEAbiological_process
GO:0048854brain morphogenesisIEAbiological_process
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0050435beta-amyloid metabolic processIEAbiological_process
GO:0007613memoryIEAbiological_process
GO:0007220Notch receptor processingIBAbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0060048cardiac muscle contractionIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0004190aspartic-type endopeptidase activityIEAmolecular_function
GO:0051604protein maturationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043198dendritic shaftIBAcellular_component
GO:0002286T cell activation involved in immune responseIEAbiological_process
GO:0002573myeloid leukocyte differentiationIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0030424axonIBAcellular_component
GO:0048286lung alveolus developmentIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0044267cellular protein metabolic processIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0048471perinuclear region of cytoplasmIBAcellular_component
GO:0042987amyloid precursor protein catabolic processIBAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0040011locomotionIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0016485protein processingIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0000139Golgi membraneIEAcellular_component
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0002244hematopoietic progenitor cell differentiationIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0031594neuromuscular junctionIBAcellular_component
GO:0000776kinetochoreIDAcellular_component
GO:0042640anagenIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0006509membrane protein ectodomain proteolysisIDAbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0043393regulation of protein bindingIEAbiological_process
GO:0050820positive regulation of coagulationIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0016324apical plasma membraneIBAcellular_component
GO:0043085positive regulation of catalytic activityIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035253ciliary rootletIBAcellular_component
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0005765lysosomal membraneIBAcellular_component
GO:0005743mitochondrial inner membraneIBAcellular_component
GO:0030900forebrain developmentIEAbiological_process
GO:0004175endopeptidase activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0032469endoplasmic reticulum calcium ion homeostasisIEAbiological_process