Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	SP1_HUMAN
Description:	Sp1 transcription factor [Source:HGNC Symbol;Acc:11205]
Location:	chr12 q13.13
Node attribute:	gene; substrate; TF

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
T739	GSGTAtPSALI	Erk1	RegPhos
T739	GSGTAtPSALI	Erk2	RegPhos
S41	SQARSsSTGSS		HPRD; phosphoELM
S2	QDHS		HPRD
S617	SEGRGsGDPGK		PhosphoSitePlus; HPRD
T453	PIIIRtPTVGP	Erk2(MAPK1	RegPhos
S2	____MsDQDHS		PhosphoSitePlus
T651	HLRWHtGERPF	zf-H2C2_2	PhosphoSitePlus; SysPTM
T668	CGKRFtRSDEL	zf-H2C2_2	PhosphoSitePlus
S42	QARSSsTGSSS		HPRD; phosphoELM
T453	PIIIRtPTVGP	Erk2	RegPhos
S56	GGGQEsQPSPL		PhosphoSitePlus; HPRD; phosphoELM
S40	FSQARsSSTGS		HPRD; phosphoELM
T579	GIHDDtAGGEE	CK2a1	RegPhos
T453	PIIIRtPTVGP		PhosphoSitePlus; phosphoELM
T651	HLRWHtGERPF		HPRD; phosphoELM; SysPTM
T739	GSGTAtPSALI	Erk1(MAPK3	RegPhos
S48	TGSSSsTGGGG		HPRD; phosphoELM
S36	GGGAFsQARSS		PhosphoSitePlus
T739	GSGTAtPSALI		PhosphoSitePlus; phosphoELM
S702	RSDHLsKHIKT		PhosphoSitePlus
S670	KRFTRsDELQR		PhosphoSitePlus
S46	SSTGSsSSTGG		HPRD; phosphoELM
T681	HKRTHtGEKKF	zf-H2C2_2; RRN7	PhosphoSitePlus
S732	DSGAGsEGSGT		PhosphoSitePlus
T278	SAATLtPSSQA		PhosphoSitePlus
T579	GIHDDtAGGEE	CSNK2A1	HPRD
T375	IQQNQtSGGSL		HPRD
T453	PIIIRtPTVGP	MAPK3	HPRD; phosphoELM
T453	PIIIRtPTVGP	MAPK1	HPRD; phosphoELM
S728	TLPLDsGAGSE		PhosphoSitePlus
T579	GIHDDtAGGEE	CK2_group	phosphoELM; RegPhos
S59	QESQPsPLALL		PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S7	DEMT		HPRD
T739	GSGTAtPSALI	MAPK1	HPRD; phosphoELM
T43	ARSSStGSSSS		HPRD; phosphoELM
T12	SMDEMtAVVKI		PhosphoSitePlus
T453	PIIIRtPTVGP	Erk1(MAPK3	RegPhos
S7	SDQDHsMDEMT		PhosphoSitePlus; RegPhos
T739	GSGTAtPSALI	Erk2(MAPK1	RegPhos
S101	TATQLsQGANG		PhosphoSitePlus
T453	PIIIRtPTVGP	Erk1	RegPhos
T679	QRHKRtHTGEK	zf-H2C2_2; RRN7	PhosphoSitePlus
T707	SKHIKtHQNKK		PhosphoSitePlus
T739	GSGTAtPSALI	MAPK3	HPRD; phosphoELM
S641	VYGKTsHLRAH		PhosphoSitePlus
T579	GIHDDtAGGEE	CK2a1-rs	RegPhos

Dephosphorylation site

SP1_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000329357	Q468*	COSMIC	Melanoma
ENSP00000329357	E387Q	COSMIC	Breast Cancer	19812674

Differential expressed protein

SP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

Site	Peptide	Cancer name	Pubmed	Source
S59	GGQESQPsPLALLAA	SLE	21097497	PhosphoSitePlus
T739	SEGSGTAtPSALITT	lung cancer	22266860	PhosphoSitePlus

Direct Interaction Pair

Source	Target	Relationship	Resource
MK01_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
MK03_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
CSK21_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD
ZAGL2_HUMAN	SP1_HUMAN	kinase -> substrate	RegPhos
SP1_HUMAN	SOMA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	EPOR_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CATD_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	GFAP_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SPR1B_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	APOB_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MIP_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SOAT1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CO1A2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	INVO_HUMAN	TF -> target gene	TRANSFAC
SP3_HUMAN	SP1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	GLI1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	LEUK_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	KC1A_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CXA1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	RET4_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TERT_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TNFA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	IL10_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	NOS1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	RL10_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	EGLN_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	FOSL1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HSPB1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HBAZ_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	LCAT_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	K6PF_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	GROA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	DYR_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	DHB1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HNF4A_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	ATF2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HSP71_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	NOS3_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TYSY_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	U627C_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	IFNG_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	NOP2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	FURIN_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	EGFR_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HBA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	U2AFM_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	DFFB_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CO1A1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MYBA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	K1C16_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HAP1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HMOX1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HAND1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HBG1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	PDGFB_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TNR6_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	PTC1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	K1C18_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TGFA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	LORI_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	PTHR_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CAV1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	P53_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	ASSY_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	NPY_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	ALDOA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	PSN1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CSH_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	BAX_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MT2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	RARA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	KIT_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	ITAM_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TGFB1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	GLPC_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	ADA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CDK2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	GLPB_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TGFR1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TCAM1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	PAI2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SOX3_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TVA2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	INSR_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	EDA_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	APOE_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TPIS_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CCL2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CO4A1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	HBE_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	FGFR4_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TF65_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	AP2C_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SP3_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SREC_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CDN1A_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MDR1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SFPA2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CCND3_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	AOFB_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	DOPO_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CO4A2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	KITH_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CD53_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	RASN_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	5HT1A_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	DPOLB_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	IL2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CCND2_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	FA10_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MPCP_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	PHX2A_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	MAZ_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	SP1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	TTF1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	KLF5_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	ACTC_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	RET_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CP21A_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CEAM6_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05202	Transcriptional misregulation in cancer
hsa04350	TGF-beta signaling pathway
hsa05016	Huntington's disease

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0045893	positive regulation of transcription, DNA-dependen	IDA	biological_process
GO:0043353	enucleate erythrocyte differentiation	IEA	biological_process
GO:0035035	histone acetyltransferase binding	IEA	molecular_function
GO:0006367	transcription initiation from RNA polymerase II pr	TAS	biological_process
GO:0001103	RNA polymerase II repressing transcription factor	ISS	molecular_function
GO:0043425	bHLH transcription factor binding	ISS	molecular_function
GO:0043565	sequence-specific DNA binding	IEA	molecular_function
GO:0001892	embryonic placenta development	IEA	biological_process
GO:0030324	lung development	IEA	biological_process
GO:0001503	ossification	IEA	biological_process
GO:0042826	histone deacetylase binding	IPI	molecular_function
GO:0003677	DNA binding	IDA	molecular_function
GO:0003677	DNA binding	IEA	molecular_function
GO:0001701	in utero embryonic development	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0008134	transcription factor binding	IPI	molecular_function
GO:0006355	regulation of transcription, DNA-dependent	IDA	biological_process
GO:0006355	regulation of transcription, DNA-dependent	IEA	biological_process
GO:0032993	protein-DNA complex	IEA	cellular_component
GO:0060216	definitive hemopoiesis	IEA	biological_process
GO:0000978	RNA polymerase II core promoter proximal region se	ISS	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor	IDA	molecular_function
GO:0008270	zinc ion binding	IEA	molecular_function
GO:0035326	enhancer binding	IEA	molecular_function
GO:0048596	embryonic camera-type eye morphogenesis	IEA	biological_process
GO:0030219	megakaryocyte differentiation	IEA	biological_process
GO:0006357	regulation of transcription from RNA polymerase II	IEA	biological_process
GO:0010467	gene expression	TAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor	IEA	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0071837	HMG box domain binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0001829	trophectodermal cell differentiation	IEA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006351	transcription, DNA-dependent	TAS	biological_process
GO:0043923	positive regulation by host of viral transcription	IDA	biological_process
GO:0043565	sequence-specific DNA binding	IDA	molecular_function
GO:0001889	liver development	IEA	biological_process
GO:0003690	double-stranded DNA binding	IEA	molecular_function
GO:0001077	RNA polymerase II core promoter proximal region se	IEA	molecular_function
GO:0019048	virus-host interaction	IEA	biological_process
GO:0048706	embryonic skeletal system development	IEA	biological_process
GO:0008022	protein C-terminus binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0045944	positive regulation of transcription from RNA poly	IDA	biological_process
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0060136	embryonic process involved in female pregnancy	IEA	biological_process
GO:0000979	RNA polymerase II core promoter sequence-specific	IEA	molecular_function
GO:0000987	core promoter proximal region sequence-specific DN	IEA	molecular_function
GO:0007179	transforming growth factor beta receptor signaling	TAS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network