Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNRPK_HUMAN
Description:heterogeneous nuclear ribonucleoprotein K [Source:HGNC Symbol;Acc:5044]
Location:chr9 q21.32
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S214ILDLIsESPIKPhi-29_GP3PhosphoSitePlus
Y458NSVKQySGKFFPhosphoSitePlus
S141QHYKGsDFDCEPhosphoSitePlus
S77YNASVsVPDSSKH_1PhosphoSitePlus
S302GGRGGsRARNLPKCdRegPhos
Y373GYDYSyAGGRGPhosphoSitePlus
Y236DETYDyGGFTMSrcRegPhos
T3METEQpEERegPhos
S216DLISEsPIKGRJNK3(MAPK10RegPhos
Y236DETYDyGGFTMSRCHPRD; phosphoELM; RegPhos
S302GGRGGsRARNLPRKCDHPRD
S302GGRGGsRARNLPKC_deltaphosphoELM
S420HESGAsIKIDEHPRD
T120PSPTAtSQLPLPhosphoSitePlus; HPRD; phosphoELM
Y234FYDETyDYGGFSRCHPRD; phosphoELM; RegPhos
S127QLPLEsDAVECHPRD
S353AIDTWsPSEWQJNK3(MAPK10RegPhos
S284DYDDMsPRRGPPKC_deltaphosphoELM
S302GGRGGsRARNLPKCd(PKC deltaRegPhos
Y236DETYDyGGFTMPhi-29_GP3PhosphoSitePlus
Y323GDLMAyDRRGRPhosphoSitePlus
Y230YDPNFyDETYDPhi-29_GP3PhosphoSitePlus
S353AIDTWsPSEWQMAPK3phosphoELM
Y230YDPNFyDETYDSRCHPRD; phosphoELM; RegPhos
Y72ALRTDyNASVSSRCHPRD; RegPhos
S284DYDDMsPRRGPMAPK10HPRD
S284DYDDMsPRRGPPKCd(PKC deltaRegPhos
S353AIDTWsPSEWQErk1(MAPK3RegPhos
S379AGGRGsYGDLGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T440ITITGtQDQIQKH_1PhosphoSitePlus
S216DLISEsPIKGRMAPK10HPRD; phosphoELM
S284DYDDMsPRRGPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S116GLQLPsPTATSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T39KRSRNtDEMVEROKNTPhosphoSitePlus
S353AIDTWsPSEWQMAPK10HPRD; phosphoELM
S216DLISEsPIKGRJNK3RegPhos
S36QAFKRsRNTDEHPRD; phosphoELM; RegPhos
S417QIRHEsGASIKHPRD
S284DYDDMsPRRGPJNK3RegPhos
Y138LNYQHyKGSDFPhosphoSitePlus
S276RPMPPsRRDYDPhosphoSitePlus
T390GPIITtQVTIPKH_1PhosphoSitePlus
Y225GRAQPyDPNFYPhi-29_GP3PhosphoSitePlus
Y371GSGYDySYAGGPhosphoSitePlus
Y333RPGDRyDGMVGPhosphoSitePlus
Y234FYDETyDYGGFSrcRegPhos
S121SPTATsQLPLEPhosphoSitePlus
S353AIDTWsPSEWQMAPK8phosphoELM
S353AIDTWsPSEWQJNK1(MAPK8RegPhos
S353AIDTWsPSEWQJNK3RegPhos
S372SGYDYsYAGGRPhosphoSitePlus
Y380GGRGSyGDLGGSrcRegPhos
S214ILDLIsESPIKHPRD; RegPhos
T118QLPSPtATSQLPhosphoSitePlus; HPRD; phosphoELM
Y72ALRTDyNASVSKH_1PhosphoSitePlus
Y380GGRGSyGDLGGSRCphosphoELM
Y280PSRRDyDDMSPPhosphoSitePlus; HPRD
S302GGRGGsRARNLPhosphoSitePlus
Y361EWQMAyEPQGGPhosphoSitePlus
Y380GGRGSyGDLGGPhosphoSitePlus; HPRD; phosphoELM
Y449IQNAQyLLQNSKH_1PhosphoSitePlus
Y234FYDETyDYGGFPhi-29_GP3PhosphoSitePlus
S154LLIHQsLAGGIKH_1; Phi-29_GP3PhosphoSitePlus
Y230YDPNFyDETYDSrcRegPhos
S353AIDTWsPSEWQPhosphoSitePlus; phosphoELM
Y225GRAQPyDPNFYSRCHPRD; RegPhos
S216DLISEsPIKGRPhi-29_GP3PhosphoSitePlus
T3___MEtEQPEEROKNTPhosphoSitePlus
S216DLISEsPIKGRHPRD; phosphoELM; RegPhos
S401KDLAGsIIGKGHPRD
S401KDLAGsIIGKGKH_1PhosphoSitePlus
T3QPEEHPRD; phosphoELM
S284DYDDMsPRRGPMAPK3phosphoELM
Y369QGGSGyDYSYAPhosphoSitePlus
Y135VECLNyQHYKGPhosphoSitePlus; HPRD

Dephosphorylation site
HNRPK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365439G376DCOSMICMelanoma
ENSP00000365458G376DCOSMICMelanoma
ENSP00000365444G376DCOSMICMelanoma

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000365440Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000365440LeukemiaNormal vs. Cancercell lineDown0.4517022645
ENSP00000365440LeukemiaNormal vs. Cancercell lineDown0.4517022645
ENSP00000365440Oral Premalignant LesionsNormal vs. CancertissueUp9.919072117
ENSP00000365440Oral Premalignant LesionsNormal vs. CancertissueUp1.119072117
ENSP00000365440Oral Premalignant LesionsNormal vs. CancertissueUp1.119072117
ENSP00000365440Oral Premalignant LesionsNormal vs. CancertissueUp1.719072117
ENSP00000365440Oral Premalignant LesionsNormal vs. CancertissueUp1.219072117
ENSP00000365440Oral Premalignant LesionsNormal vs. CancertissueUp1.519072117
ENSP00000365440Esophageal CancerNormal vs. CancertissueDown0.2719142970
ENSP00000365440hepatitis B virusTreatment (none vs tetracycline-treatment)cell lineUp219671925
ENSP00000365440Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.3120804217
ENSP00000365440Breast CancerNormal vs. Cancercell lineDown0.3820052998
ENSP00000365440Breast CancerNormal vs. Cancercell lineDown0.4220052998
ENSP00000365440Breast CancerMetastasiscell lineUp1.220052998
ENSP00000365440acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1617655343
ENSP00000365440acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown17655343
ENSP00000365440acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.3417655343
ENSP00000365440Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.5616807943
ENSP00000365440Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.6116807943
ENSP00000365440Biliary Tract CancerMetastasiscell lineUp3.619299076

Hyperphosphorylation site
HNRPK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANHNRPK_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCL_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANHNRPK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BMX_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANHNRPK_HUMANkinase -> substrateRegPhos
NEK3_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANHNRPK_HUMANkinase -> substrateRegPhos
FAK2_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANHNRPK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
EPHB3_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
HNRPK_HUMANMYC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03040Spliceosome
hsa05203Viral carcinogenesis
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0008380RNA splicingTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIMPmolecular_function
GO:0006396RNA processingTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0003697single-stranded DNA bindingTASmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0045716positive regulation of low-density lipoprotein parIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010988regulation of low-density lipoprotein particle cleIMPbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIMPmolecular_function
GO:0048260positive regulation of receptor-mediated endocytosIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0072369regulation of lipid transport by positive regulatiIMPbiological_process
GO:0007165signal transductionTASbiological_process
GO:0003723RNA bindingIEAmolecular_function


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