Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HCLS1_HUMAN
Description:hematopoietic cell-specific Lyn substrate 1 [Source:HGNC Symbol;Acc:4844]
Location:chr3 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y175KAALGyDYKGEHS1_repPhosphoSitePlus
Y161GFGGRyGVEKDHS1_repPhosphoSitePlus
S186TEKHEsQRDYAHS1_repPhosphoSitePlus
Y124GFGGKyGVERDHS1_repPhosphoSitePlus
Y222APTTAyKKTTPLynphosphoELM; RegPhos
T16SVSVEtQGDDWCK2a1RegPhos
Y103AVGHEyVAEVEHPRD; phosphoELM; RegPhos
S275AVTKRsPEAPQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y198GFGGQyGIQKDHPRD; phosphoELM; RegPhos
Y397EPEGDyEEVLELYNHPRD; RegPhos
Y397EPEGDyEEVLEPhosphoSitePlus; phosphoELM
Y378EPENDyEDVEESykRegPhos
Y397EPEGDyEEVLESYKHPRD; phosphoELM; RegPhos
Y397EPEGDyEEVLEFgrphosphoELM; RegPhos
Y378EPENDyEDVEELynphosphoELM; RegPhos
T272ERKAVtKRSPEPhosphoSitePlus
Y378EPENDyEDVEESYKHPRD; phosphoELM; RegPhos
T16SVSVEtQGDDWCK2a1-rsRegPhos
Y378EPENDyEDVEELYNHPRD; RegPhos
Y481LFPANyVKLLEPhosphoSitePlus
Y222APTTAyKKTTPLYNHPRD; RegPhos
Y140AVGFDyKGEVERegPhos
Y190ESQRDyAKGFGHS1_repPhosphoSitePlus
Y397EPEGDyEEVLESykRegPhos
Y222APTTAyKKTTPFgrphosphoELM; RegPhos
T23GDDWDtDPDFVCSNK2A1HPRD
S154SQKDYsRGFGGHS1_repPhosphoSitePlus
S134DRADKsAVGFDHS1_repPhosphoSitePlus
T16SVSVEtQGDDWCSNK2A1HPRD
Y198GFGGQyGIQKDHS1_repPhosphoSitePlus
S97DRMDKsAVGHEHS1_repPhosphoSitePlus
T16SVSVEtQGDDWPhosphoSitePlus
T23GDDWDtDPDFVCK2a1-rsRegPhos
Y83KASHGyGGRFGHS1_repPhosphoSitePlus
Y140AVGFDyKGEVEHS1_repPhosphoSitePlus
S208DRVDKsAVGFNHS1_repPhosphoSitePlus
Y222APTTAyKKTTPFGRHPRD; RegPhos
T308WPPVGtPPSSEPhosphoSitePlus
T42RWGAKtIEGSGPhosphoSitePlus
Y397EPEGDyEEVLELynphosphoELM; RegPhos
Y103AVGHEyVAEVEHS1_repPhosphoSitePlus
T23GDDWDtDPDFVCK2a1RegPhos
Y222APTTAyKKTTPPhosphoSitePlus; RegPhos
T333LPIRQtLPEDNPhosphoSitePlus
S32FVNDIsEKEQRPhosphoSitePlus
Y177ALGYDyKGETEHS1_repPhosphoSitePlus
T23GDDWDtDPDFVPhosphoSitePlus
Y153TSQKDySRGFGHS1_repPhosphoSitePlus
Y378EPENDyEDVEEPhosphoSitePlus; phosphoELM
Y360EEEPVyEAEPEPhosphoSitePlus; phosphoELM; RegPhos
T181DYKGEtEKHESHS1_repPhosphoSitePlus

Dephosphorylation site
HCLS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320176R469HCOSMICCentral Nervous System Neoplasms21817013
ENSP00000320176R347KCOSMICSkin Cancer21984974
ENSP00000320176E214DCOSMICHead and Neck Cancer21798893

Differential expressed protein
HCLS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HCLS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EPHA3_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANHCLS1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
AURKB_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
HIPK4_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
HIPK1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
PDK1L_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANHCLS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1E_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANHCLS1_HUMANkinase -> substrateRegPhos
BUB1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANHCLS1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MAPK5_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANHCLS1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
AKT1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
SGK1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa04530Tight junction
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmISScellular_component
GO:0005634nucleusISScellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042993positive regulation of transcription factor importIMPbiological_process
GO:2000107negative regulation of leukocyte apoptotic processIMPbiological_process
GO:2000251positive regulation of actin cytoskeleton reorganiICbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0005667transcription factor complexIDAcellular_component
GO:0071345cellular response to cytokine stimulusIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0009725response to hormone stimulusISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030833regulation of actin filament polymerizationIMPbiological_process
GO:0042531positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0030854positive regulation of granulocyte differentiationIMPbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIMPbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0042531positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0030218erythrocyte differentiationISSbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process


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