| UniProt/SwissProt ID: | HS105_HUMAN |
| Description: | heat shock 105kDa/110kDa protein 1 [Source:HGNC Symbol;Acc:16969] |
| Location: | chr13 q12.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S509 | EENEMsSEADM | CSNK2A2 | HPRD |
| S509 | EENEMsSEADM | CSNK2A1 | HPRD |
| S557 | SQSPPsPELTS | HSP70 | PhosphoSitePlus |
| T815 | PKLERtPNGPN | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S554 | QQTSQsPPSPE | HPRD | |
| S509 | EENEMsSEADM | RegPhos | |
| T700 | LMKIGtPVKVR | HPRD; phosphoELM | |
| Y677 | TEDWLyEEGED | HSP70 | PhosphoSitePlus |
| S132 | ETAENsLKKPV | HSP70 | PhosphoSitePlus |
| S493 | GIFTIsTASMV | HSP70 | PhosphoSitePlus |
| S509 | EENEMsSEADM | CK2a2 | RegPhos |
| S509 | EENEMsSEADM | CK2a1 | RegPhos |
| S384 | QCAILsPAFKV | phosphoELM; RegPhos | |
| T25 | AGGIEtIANEF | HSP70 | PhosphoSitePlus |
| T672 | RLLTEtEDWLY | HSP70 | PhosphoSitePlus |
| S384 | QCAILsPAFKV | HSP70 | PhosphoSitePlus |
| T700 | LMKIGtPVKVR | HSP70 | PhosphoSitePlus |
| S31 | IANEFsDRCTP | RegPhos | |
| S10 | GLDVGsQSCYI | HSP70 | PhosphoSitePlus |
| S809 | KPKIEsPKLER | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y89 | KENLSyDLVPL | HSP70 | PhosphoSitePlus |
| Y688 | QAKQAyVDKLE | HSP70 | PhosphoSitePlus |
| Y641 | NAVEEyVYEFR | HSP70 | PhosphoSitePlus |
| S562 | SPELTsEENKI | HPRD | |
| T670 | FLRLLtETEDW | HSP70 | PhosphoSitePlus |
| Y643 | VEEYVyEFRDK | HSP70 | PhosphoSitePlus |
| T365 | KDISTtLNADE | HSP70 | PhosphoSitePlus |
| S429 | HAAPFsKVLTF | HSP70 | PhosphoSitePlus |
| Y14 | GSQSCyIAVAR | HSP70 | PhosphoSitePlus |
| S852 | PNEKNsVNMDL | PhosphoSitePlus | |
| T486 | KVRVNtHGIFT | HSP70 | PhosphoSitePlus |
| T494 | IFTIStASMVE | HSP70 | PhosphoSitePlus |
| S509 | EENEMsSEADM | CK2a1-rs | RegPhos |
| S31 | IANEFsDRCTP | HSP70 | PhosphoSitePlus |
| S557 | SQSPPsPELTS | HPRD; phosphoELM; RegPhos | |
| S12 | DVGSQsCYIAV | HSP70 | PhosphoSitePlus |
| Dephosphorylation site |
| HS105_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318687 | M174L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318687 | E24K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000318687 | Gastric Cancer | Metastasis | cell line | Up | 1.6 | 17022644 | ENSP00000318687 | Gastric Cancer | Metastasis | cell line | Up | 1.6 | 17022644 | ENSP00000318687 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.52 | 20739354 |
| Hyperphosphorylation site |
| HS105_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | HS105_HUMAN | kinase -> substrate | RegPhos |
| CSK22_HUMAN | HS105_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | HS105_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04141 | Protein processing in endoplasmic reticulum |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0000902 | cell morphogenesis | IEA | biological_process |
| GO:0006986 | response to unfolded protein | TAS | biological_process |
| GO:0043014 | alpha-tubulin binding | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0045345 | positive regulation of MHC class I biosynthetic pr | TAS | biological_process |
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0051135 | positive regulation of NK T cell activation | TAS | biological_process |
| GO:0051085 | chaperone mediated protein folding requiring cofac | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |