| UniProt/SwissProt ID: | FKBP4_HUMAN |
| Description: | FK506 binding protein 4, 59kDa [Source:HGNC Symbol;Acc:3720] |
| Location: | chr12 p13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S453 | TAGSQsQVETE | PhosphoSitePlus; RegPhos; SysPTM | |
| T143 | KGEDLtEEEDG | CK2a1-rs | RegPhos |
| Y293 | QALLQyKKIVS | TPR_1 | PhosphoSitePlus |
| S451 | SNTAGsQSQVE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y225 | YLKPSyAFGSV | FKBP_C | PhosphoSitePlus |
| Y411 | REKKLyANMFE | PhosphoSitePlus; HPRD; SysPTM | |
| T438 | DHPTDtEMKEE | PhosphoSitePlus | |
| Y161 | TRGEGyAKPNE | FKBP_C | PhosphoSitePlus |
| T436 | SGDHPtDTEMK | PhosphoSitePlus | |
| S217 | EKGEHsIVYLK | FKBP_C | PhosphoSitePlus |
| T143 | KGEDLtEEEDG | CK2_group | RegPhos |
| S430 | AKAEAsSGDHP | PhosphoSitePlus | |
| Y220 | EHSIVyLKPSY | FKBP_C | PhosphoSitePlus |
| S453 | TAGSQsQVET | HPRD; phosphoELM; SysPTM | |
| Y286 | FKEGKyKQALL | TPR_1 | PhosphoSitePlus |
| T143 | KGEDLtEEEDG | CSNK2A1 | HPRD |
| Y293 | QALLQyKKIVS | HPRD | |
| S431 | KAEASsGDHPT | PhosphoSitePlus | |
| S305 | LEYESsFSNEE | PhosphoSitePlus | |
| T448 | EQKSNtAGSQS | PhosphoSitePlus | |
| T143 | KGEDLtEEEDG | CK2a1 | RegPhos |
| Dephosphorylation site |
| FKBP4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000001008 | R276Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000001008 | R402K | COSMIC | Skin Cancer | 21984974 | ENSP00000001008 | L382V | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000001008 | Gastric Cancer | Metastasis | cell line | Up | 1.5 | 17022644 | ENSP00000001008 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.6 | 19098285 | ENSP00000001008 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 3 | 15759316 | ENSP00000001008 | Prostate Cancer | Metastasis | tissue | Up | 2.5 | 18553995 | ENSP00000001008 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Up | 2.9 | 18491314 | ENSP00000001008 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 2.9 | 16097030 | ENSP00000001008 | Gastric Cancer | Metastasis | cell line | Up | 1.5 | 17022644 | ENSP00000001008 | Breast Cancer | Normal vs. Cancer | cell line | Up | 2.8 | 20052998 | ENSP00000001008 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.93 | 20052998 | ENSP00000001008 | Breast Cancer | Metastasis | cell line | Down | 0.33 | 20052998 | ENSP00000001008 | Ovarian Cancer | Metastasis | cell line | Down | 17892554 |
| Hyperphosphorylation site |
| FKBP4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | FKBP4_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | FKBP4_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| FKBP4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031111 | negative regulation of microtubule polymerization | ISS | biological_process |
| GO:0007566 | embryo implantation | IEA | biological_process |
| GO:0048156 | tau protein binding | IEA | molecular_function |
| GO:0046661 | male sex differentiation | IEA | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA | molecular_function |
| GO:0005622 | intracellular | NAS | cellular_component |
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0044295 | axonal growth cone | IEA | cellular_component |
| GO:0018208 | peptidyl-proline modification | IBA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0032767 | copper-dependent protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0010977 | negative regulation of neuron projection developme | ISS | biological_process |
| GO:0035259 | glucocorticoid receptor binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005528 | FK506 binding | IBA | molecular_function |
| GO:0048608 | reproductive structure development | IEA | biological_process |
| GO:0031115 | negative regulation of microtubule polymerization | IEA | biological_process |
| GO:0006463 | steroid hormone receptor complex assembly | IEA | biological_process |
| GO:0030521 | androgen receptor signaling pathway | IEA | biological_process |
| GO:0000413 | protein peptidyl-prolyl isomerization | IBA | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0030850 | prostate gland development | IEA | biological_process |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0031072 | heat shock protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0030674 | protein binding, bridging | TAS | molecular_function |
| GO:0006457 | protein folding | IEA | biological_process |
| GO:0031503 | protein complex localization | IEA | biological_process |
| GO:0061077 | chaperone-mediated protein folding | IDA | biological_process |
| GO:0051219 | phosphoprotein binding | IEA | molecular_function |
| GO:0006825 | copper ion transport | IEA | biological_process |
| GO:0016020 | membrane | IBA | cellular_component |