Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNRPC_HUMAN
Description:heterogeneous nuclear ribonucleoprotein C (C1/C2) [Source:HGNC Symbol;Acc:5035]
Location:chr14 q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S238SEEEQsSSSVKViral_P18; Alpha-2-MRAP_CPhosphoSitePlus
S306NGEDHPRD; phosphoELM
S108EMYGSsFDLDYHPRD
S138YDRMYsYPARVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S286EDDRDsANGEDHPRD
S166VSGNTsRRGKSPhosphoSitePlus
S240NVKMEsEGGADHPRD
S260GGADDsAEEGDCSNK2A2HPRD
S239EEEQSsSSVKKHPRD; phosphoELM; RegPhos
S299EDDRDsANGEDCK1_alphaphosphoELM
S121PLLSSsFDLDYPhosphoSitePlus; phosphoELM
S31LVVKKsDVEAIRRM_1PhosphoSitePlus
S162KSGFNsKSGQRHPRD
S260GGADDsAEEGDCSNK2A1HPRD
S253NVKMEsEGGADCK1_alphaphosphoELM
Y57FAFVQyVNERNRRM_1PhosphoSitePlus
S253NVKMEsEGGADCSNK1A1HPRD
T234VKKDEtNVKMEHPRD
S260GGADDsAEEGDHPRD; phosphoELM; RegPhos
S119PSPLLsSSFDLPhosphoSitePlus; HPRD
S183GQRGSsKSGKLHPRD
S306NGEDDs_____PhosphoSitePlus
S240EEQSSsSVKKDHPRD; phosphoELM; RegPhos
S175KSGFNsKSGQRHPRD
T247VKKDEtNVKMEHPRD
S115EHPSPsPLLSSPhosphoSitePlus; HPRD; phosphoELM
T109MYGSVtEHPSPPhosphoSitePlus; HPRD; phosphoELM
S239EEEQSsSSVKKViral_P18; Alpha-2-MRAP_CPhosphoSitePlus
S247GGADDsAEEGDCSNK2A2HPRD
S107AEMYGsVTEHPHPRD
Y105SAAEMyGSSFDHPRD
S260GGADDsAEEGDCK2a1-rsRegPhos
S238SEEEQsSSSVKHPRD; phosphoELM; RegPhos
S233MKNDKsEEEQSViral_P18; Alpha-2-MRAP_CPhosphoSitePlus
Y139DRMYSyPARVPPhosphoSitePlus
S241EQSSSsVKKDEHPRD; phosphoELM; RegPhos
S225SEEEQsSSSVKHPRD
S253NVKMEsEGGADCK1aRegPhos
S299EDDRDsANGEDHPRD; phosphoELM; RegPhos
Y137YYDRMySYPARPhosphoSitePlus
S247GGADDsAEEGDHPRD
S253NVKMEsEGGADHPRD; phosphoELM; RegPhos
S240EEQSSsSVKKDCK1aRegPhos
S149KRQRVsGNTSRHPRD
S38VEAIFsKYGKIRRM_1PhosphoSitePlus
S293NGEDHPRD
S260GGADDsAEEGDCK2a1RegPhos
S260GGADDsAEEGDCK2a2RegPhos
S260GGADDsAEEGDCK1a(CK1 alphaRegPhos
S125YDRMYsYPARVHPRD
S156RAVVPsKRQRVPhosphoSitePlus; HPRD
S299EDDRDsANGEDRP-C_CPhosphoSitePlus
S228EQSSSsVKKDEHPRD
S209KQKVDsLLENLViral_P18; Alpha-2-MRAP_CPhosphoSitePlus
S226EEEQSsSSVKKHPRD
S299EDDRDsANGEDCK1a(CK1 alphaRegPhos
S162KRQRVsGNTSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S240NVKMEsEGGADCSNK1A1HPRD
Y105SAAEMyGSVTEphosphoELM
Y132DFQRDyYDRMYPhosphoSitePlus
Y126SFDLDyDFQRDPhosphoSitePlus
S241EQSSSsVKKDEAlpha-2-MRAP_C; DUF2422; PhosphoSitePlus
S253NVKMEsEGGADCK1a(CK1 alphaRegPhos
S143RAVVPsKRQRVHPRD
S260GGADDsAEEGDCK2_groupphosphoELM; RegPhos
T165RVSGNtSRRGKPhosphoSitePlus
S113VTEHPsPSPLLPhosphoSitePlus; HPRD; phosphoELM
S170GQRGSsKSGKLHPRD
S227EEQSSsSVKKDHPRD
S240EEQSSsSVKKDViral_P18; Alpha-2-MRAP_CPhosphoSitePlus
S260GGADDsAEEGDAlpha-2-MRAP_C; DUF2422; PhosphoSitePlus
S220MKNDKsEEEQSHPRD
S107AEMYGsSFDLDHPRD
S120SPLLSsSFDLDPhosphoSitePlus; phosphoELM
S100AGVKRsAAEMYHPRD; phosphoELM
S306NGEDDsRegPhos
S247GGADDsAEEGDCSNK2A1HPRD
S253NVKMEsEGGADAlpha-2-MRAP_C; DUF2422; PhosphoSitePlus
S260GGADDsAEEGDCK1_alphaphosphoELM
S233MKNDKsEEEQSHPRD; phosphoELM; RegPhos
Y133FQRDYyDRMYSPhosphoSitePlus

Dephosphorylation site
HNRPC_HUMAN do not have dephosphorylation site.

Mutation site
HNRPC_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000319690Hepatocellular CarcinomaNormal vs. Cancercell lineUp5.518646787
ENSP00000319690Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000319690Hepatocellular CarcinomaNormal vs. CancertissueUp2.317627933
ENSP00000319690MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) silenced)cell lineUp2.217854218
ENSP00000319690Colorectal CancerTreatment (none vs transfected with HPV-16 E6 gene)cell lineDown15684709
ENSP00000319690Colorectal CancerTreatment (none vs transfected with HPV-16 E6 gene)cell lineDown15684709
ENSP00000319690Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp2.119137550
ENSP00000319690Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp1.319137550
ENSP00000319690Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.3320804217
ENSP00000319690Oral CancerNormal vs. CancertissueUp319691830
ENSP00000319690acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000319690acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0817655343
ENSP00000319690acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1117655343
ENSP00000319690acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000319690acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
HNRPC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANHNRPC_HUMANkinase -> substrateHPRD
KC1A_HUMANHNRPC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANHNRPC_HUMANkinase -> substrateRegPhos
CSK22_HUMANHNRPC_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03040Spliceosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008380RNA splicingTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0045120pronucleusIEAcellular_component
GO:0005681spliceosomal complexIDAcellular_component
GO:0003723RNA bindingNASmolecular_function
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0003729mRNA bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function