| UniProt/SwissProt ID: | VTNC_HUMAN |
| Description: | SEBOX homeobox [Source:HGNC Symbol;Acc:32942] |
| Location: | chrHG883_PATCH q11.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y420 | NNYDDyRMDWL | PhosphoSitePlus | |
| S397 | NSRRPsRATWL | PRKACA | HPRD |
| S381 | RKGYRsQRGHS | PKCa | RegPhos |
| S381 | RKGYRsQRGHS | PKCb | RegPhos |
| Y179 | AFRGQyCYELD | Hemopexin | PhosphoSitePlus |
| T69 | RGDVFtMPEDE | CK2a1 | RegPhos |
| T76 | PEDEYtVYDDG | CK2a1(CK2 alpha | RegPhos |
| T76 | PEDEYtVYDDG | CK2a1-rs | RegPhos |
| T69 | RGDVFtMPEDE | CK2_alpha | phosphoELM |
| T76 | PEDEYtVYDDG | CK2_group | phosphoELM; RegPhos |
| T69 | RGDVFtMPEDE | CK2_group | phosphoELM; RegPhos |
| S397 | NSRRPsRATWL | PhosphoSitePlus | |
| T76 | PEDEYtVYDDG | CK2a1 | RegPhos |
| S381 | RKGYRsQRGHS | PKCg | RegPhos |
| S171 | DLKNGsLFAFR | HPRD; phosphoELM; RegPhos; SysPTM | |
| S381 | RKGYRsQRGHS | PRKCG | HPRD |
| T69 | RGDVFtMPEDE | CK2a1-rs | RegPhos |
| S397 | NSRRPsRATWL | PKA_group | phosphoELM; RegPhos |
| T76 | PEDEYtVYDDG | CSNK2A1 | HPRD |
| S312 | MMQRDsWEDIF | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T69 | RGDVFtMPEDE | CK2a1(CK2 alpha | RegPhos |
| S386 | SQRGHsRGRNQ | PhosphoSitePlus | |
| S397 | NSRRPsRATWL | PKACa | RegPhos |
| T69 | RGDVFtMPEDE | CSNK2A1 | HPRD |
| S393 | GRNQNsRRPSR | PhosphoSitePlus | |
| S381 | RKGYRsQRGHS | PRKCB | HPRD |
| S381 | RKGYRsQRGHS | PRKCA | HPRD |
| T76 | PEDEYtVYDDG | PhosphoSitePlus | |
| S381 | RKGYRsQRGHS | PhosphoSitePlus | |
| T76 | PEDEYtVYDDG | CK2_alpha | phosphoELM |
| T69 | RGDVFtMPEDE | PhosphoSitePlus | |
| Dephosphorylation site |
| VTNC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000226218 | E185K | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000226218 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 4.5 | 18715028 | ENSP00000226218 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.4 | 18667268 | ENSP00000226218 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000226218 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.11 | 17627933 | ENSP00000226218 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 |
| Hyperphosphorylation site |
| VTNC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCG_HUMAN | VTNC_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | VTNC_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | VTNC_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | VTNC_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCB_HUMAN | VTNC_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04512 | ECM-receptor interaction |
| hsa04510 | Focal adhesion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048260 | positive regulation of receptor-mediated endocytos | IDA | biological_process |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0061302 | smooth muscle cell-matrix adhesion | IDA | biological_process |
| GO:0050840 | extracellular matrix binding | IEA | molecular_function |
| GO:0071062 | alphav-beta3 integrin-vitronectin complex | TAS | cellular_component |
| GO:0090303 | positive regulation of wound healing | IC | biological_process |
| GO:0010951 | negative regulation of endopeptidase activity | IDA | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0007160 | cell-matrix adhesion | IEA | biological_process |
| GO:0014911 | positive regulation of smooth muscle cell migratio | IDA | biological_process |
| GO:0005178 | integrin binding | IPI | molecular_function |
| GO:0033627 | cell adhesion mediated by integrin | IDA | biological_process |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphory | IDA | biological_process |
| GO:0030247 | polysaccharide binding | IEA | molecular_function |
| GO:0007160 | cell-matrix adhesion | IDA | biological_process |
| GO:0005044 | scavenger receptor activity | IEA | molecular_function |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0032092 | positive regulation of protein binding | IDA | biological_process |
| GO:0030198 | extracellular matrix organization | IEA | biological_process |
| GO:0030949 | positive regulation of vascular endothelial growth | TAS | biological_process |
| GO:0030195 | negative regulation of blood coagulation | IC | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010811 | positive regulation of cell-substrate adhesion | IEA | biological_process |