Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VTNC_HUMAN
Description:SEBOX homeobox [Source:HGNC Symbol;Acc:32942]
Location:chrHG883_PATCH q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y420NNYDDyRMDWLPhosphoSitePlus
S397NSRRPsRATWLPRKACAHPRD
S381RKGYRsQRGHSPKCaRegPhos
S381RKGYRsQRGHSPKCbRegPhos
Y179AFRGQyCYELDHemopexinPhosphoSitePlus
T69RGDVFtMPEDECK2a1RegPhos
T76PEDEYtVYDDGCK2a1(CK2 alphaRegPhos
T76PEDEYtVYDDGCK2a1-rsRegPhos
T69RGDVFtMPEDECK2_alphaphosphoELM
T76PEDEYtVYDDGCK2_groupphosphoELM; RegPhos
T69RGDVFtMPEDECK2_groupphosphoELM; RegPhos
S397NSRRPsRATWLPhosphoSitePlus
T76PEDEYtVYDDGCK2a1RegPhos
S381RKGYRsQRGHSPKCgRegPhos
S171DLKNGsLFAFRHPRD; phosphoELM; RegPhos; SysPTM
S381RKGYRsQRGHSPRKCGHPRD
T69RGDVFtMPEDECK2a1-rsRegPhos
S397NSRRPsRATWLPKA_groupphosphoELM; RegPhos
T76PEDEYtVYDDGCSNK2A1HPRD
S312MMQRDsWEDIFPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T69RGDVFtMPEDECK2a1(CK2 alphaRegPhos
S386SQRGHsRGRNQPhosphoSitePlus
S397NSRRPsRATWLPKACaRegPhos
T69RGDVFtMPEDECSNK2A1HPRD
S393GRNQNsRRPSRPhosphoSitePlus
S381RKGYRsQRGHSPRKCBHPRD
S381RKGYRsQRGHSPRKCAHPRD
T76PEDEYtVYDDGPhosphoSitePlus
S381RKGYRsQRGHSPhosphoSitePlus
T76PEDEYtVYDDGCK2_alphaphosphoELM
T69RGDVFtMPEDEPhosphoSitePlus

Dephosphorylation site
VTNC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000226218E185KCOSMICHead and Neck Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000226218hepatitis C virusNormal vs. CancertissueUp4.518715028
ENSP00000226218colorectal cancerNormal vs. CancertissueUp1.418667268
ENSP00000226218Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000226218Hepatocellular CarcinomaNormal vs. CancertissueDown0.1117627933
ENSP00000226218Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
VTNC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCG_HUMANVTNC_HUMANkinase -> substrateHPRD
ZAGL2_HUMANVTNC_HUMANkinase -> substrateRegPhos
KPCA_HUMANVTNC_HUMANkinase -> substrateHPRD
CSK21_HUMANVTNC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCB_HUMANVTNC_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048260positive regulation of receptor-mediated endocytosIDAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0061302smooth muscle cell-matrix adhesionIDAbiological_process
GO:0050840extracellular matrix bindingIEAmolecular_function
GO:0071062alphav-beta3 integrin-vitronectin complexTAScellular_component
GO:0090303positive regulation of wound healingICbiological_process
GO:0010951negative regulation of endopeptidase activityIDAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioIDAbiological_process
GO:0005178integrin bindingIPImolecular_function
GO:0033627cell adhesion mediated by integrinIDAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0030247polysaccharide bindingIEAmolecular_function
GO:0007160cell-matrix adhesionIDAbiological_process
GO:0005044scavenger receptor activityIEAmolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0005615extracellular spaceIDAcellular_component
GO:0032092positive regulation of protein bindingIDAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0030949positive regulation of vascular endothelial growthTASbiological_process
GO:0030195negative regulation of blood coagulationICbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010811positive regulation of cell-substrate adhesionIEAbiological_process


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