Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FZR_HUMAN
Description:fizzy/cell division cycle 20 related 1 (Drosophila) [Source:HGNC Symbol;Acc:24824]
Location:chr19 p13.3
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S40SSPVSsPSKHGPhosphoSitePlus; HPRD; phosphoELM
S346NHSSLsPVQQYWD40PhosphoSitePlus
S163QKLLRsPRKPTPhosphoSitePlus
S137LSTKRsSPDDGPhosphoSitePlus; HPRD; phosphoELM
S163QKLLRsPRKPTCDK_groupphosphoELM; RegPhos
S151SPYSLsPVSNKCDK_groupphosphoELM; RegPhos
T300QRDIRtPPLQSPhosphoSitePlus
Y91KDGLAySALLKPhosphoSitePlus; RegPhos
S146DGNDVsPYSLSPhosphoSitePlus; HPRD; phosphoELM
S154SLSPVsNKSQKHPRD; phosphoELM
T121RLQPStPEKKGPhosphoSitePlus
S72NEKSPsQNRKAPhosphoSitePlus; phosphoELM
T30TEMRRtLTPASHPRD
S92DGLAYsALLKNPhosphoSitePlus; RegPhos
S42PVSSPsKHGDRPhosphoSitePlus; HPRD
S138STKRSsPDDGNPhosphoSitePlus; HPRD; phosphoELM
S149DVSPYsLSPVSHPRD
S120RRLQPsTPEKKPhosphoSitePlus
S343LVWNHsSLSPVPhosphoSitePlus
S39ASSPVsSPSKHHPRD
S35TLTPAsSPVSSPhosphoSitePlus
S36LTPASsPVSSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S131GLFTYsLSTKRPhosphoSitePlus
S151SPYSLsPVSNKPhosphoSitePlus; phosphoELM; RegPhos
S163QKLLRsPRKPTCDK2HPRD; RegPhos
S70NENEKsPSQNRPhosphoSitePlus; phosphoELM
T32MRRTLtPASSPPhosphoSitePlus; HPRD; phosphoELM
S151SPYSLsPVSNKCDK2HPRD; RegPhos
Y5_MDQDyERRLLPhosphoSitePlus

Dephosphorylation site
FZR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000410369Q350LCOSMICHead and Neck Cancer21798893
ENSP00000410369Q401*COSMICRenal Cancer21248752
ENSP00000410369V253ACOSMICLung Cancer
ENSP00000410369R493QCOSMICHead and Neck Cancer21798893

Differential expressed protein
FZR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FZR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANFZR_HUMANkinase -> substrateRegPhos
CDK2_HUMANFZR_HUMANkinase -> substrateRegPhos
GSK3B_HUMANFZR_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANFZR_HUMANkinase -> substrateHPRD
FZR_HUMANFZR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070979protein K11-linked ubiquitinationTASbiological_process
GO:0070306lens fiber cell differentiationIEAbiological_process
GO:0051488activation of anaphase-promoting complex activityIDAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0005680anaphase-promoting complexIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0031572G2/M transition DNA damage checkpointIDAbiological_process
GO:0045732positive regulation of protein catabolic processIGIbiological_process
GO:0090344negative regulation of cell agingIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0051301cell divisionIEAbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0040020regulation of meiosisIEAbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process