Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	JUN_HUMAN
Description:	jun proto-oncogene [Source:HGNC Symbol;Acc:6204]
Location:	chr1 p32.1
Node attribute:	TF; PPI(source); PPI(target); substrate; gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S73	LLKLAsPELER	MAPK8	HPRD; phosphoELM
S249	PIDMEsQERIK	PRKDC	HPRD
S249	PIDMEsQERIK	CK2_group	phosphoELM; RegPhos
T62	NSDLLtSPDVG	Jun	PhosphoSitePlus
S63	SDLLTsPDVGL	JNK2(MAPK9	RegPhos
S243	ETPPLsPIDME		HPRD; phosphoELM
S249	PIDMEsQERIK	CK2a1(CK2 alpha	RegPhos
S249	PIDMEsQERIK	CK2a1	RegPhos
S73	LLKLAsPELER	JNK1	RegPhos
T231	KEEPQtVPEMP	CK2a1	RegPhos
T239	EMPGEtPPLSP	GSK_group	RegPhos
S37	KILKQsMTLNL	Jun	PhosphoSitePlus
Y170	SEPPVyANLSN	ABL1	HPRD; RegPhos
T286	EEKVKtLKAQN	DUF3450; Jnk-SapK_ap_N; b	PhosphoSitePlus
S243	ETPPLsPIDME	CK2_group	phosphoELM
T93	ITTTPtPTQFL	Jun	PhosphoSitePlus
S63	SDLLTsPDVGL	JNK1(MAPK8	RegPhos
T231	KEEPQtVPEMP	CK2a1-rs	RegPhos
S243	ETPPLsPIDME	CK2a1(CK2 alpha	RegPhos
T89	SNGHItTTPTP	Jun	PhosphoSitePlus
S63	SDLLTsPDVGL	CK2_group	RegPhos
Y170	SEPPVyANLSN	Jun	PhosphoSitePlus
S48	ADPVGsLKPHL	Jun	PhosphoSitePlus
S63	SDLLTsPDVGL		phosphoELM
T239	EMPGEtPPLSP		HPRD; phosphoELM
T239	EMPGEtPPLSP	GSK-3_group	phosphoELM
S73	LLKLAsPELER	VRK1	phosphoELM; RegPhos
T95	TTPTPtQFLCP	Jun	PhosphoSitePlus
S249	PIDMEsQERIK	DUF3450; Jnk-SapK_ap_N; S	PhosphoSitePlus
T239	EMPGEtPPLSP	Jun; DUF3450	PhosphoSitePlus
T239	EMPGEtPPLSP	GSK-3_alpha	phosphoELM
S58	LRAKNsDLLTS	Jun	PhosphoSitePlus
T91	GHITTtPTPTQ		phosphoELM; RegPhos
S73	LLKLAsPELER	JNK1(MAPK8	RegPhos
T62	NSDLLtSPDVG		HPRD
S249	PIDMEsQERIK	CSNK2A1	HPRD
T2	____MtAKMET		PhosphoSitePlus
T231	KEEPQtVPEMP	CSNK2A1	HPRD
S243	ETPPLsPIDME	DUF3450; HAP1_N	PhosphoSitePlus
S73	LLKLAsPELER		HPRD; phosphoELM
S63	SDLLTsPDVGL	MAPK9	phosphoELM
S63	SDLLTsPDVGL	MAPK8	HPRD; phosphoELM
S249	PIDMEsQERIK	DNAPK	RegPhos
T231	KEEPQtVPEMP	Jun; DUF3450	PhosphoSitePlus
T231	KEEPQtVPEMP	CK2a1(CK2 alpha	RegPhos
S63	SDLLTsPDVGL	VRK1	phosphoELM; RegPhos
S63	SDLLTsPDVGL	JNK1	RegPhos
S73	LLKLAsPELER	CDK_group	RegPhos
S58	LRAKNsDLLTS		HPRD; phosphoELM
S249	PIDMEsQERIK	CK2a1-rs	RegPhos
S243	ETPPLsPIDME	GSK-3_alpha	phosphoELM
S249	PIDMEsQERIK	DNA-PK	phosphoELM
T231	KEEPQtVPEMP	CK2_alpha	phosphoELM
S63	SDLLTsPDVGL	CDK_group	RegPhos
S243	ETPPLsPIDME	GSK3A(GSK3 alpha	RegPhos
Y170	SEPPVyANLSN		HPRD; phosphoELM; RegPhos
T231	KEEPQtVPEMP	CK2_group	phosphoELM; RegPhos
T91	GHITTtPTPTQ	Jun	PhosphoSitePlus
S73	LLKLAsPELER	CK2_group	RegPhos
T239	EMPGEtPPLSP	GSK3A(GSK3 alpha	RegPhos
S63	SDLLTsPDVGL	Jun	PhosphoSitePlus
S73	LLKLAsPELER	Jun	PhosphoSitePlus
T8	AKMETtFYDDA	Jun	PhosphoSitePlus
T93	ITTTPtPTQFL		phosphoELM; RegPhos

Dephosphorylation site

JUN_HUMAN do not have dephosphorylation site.

Mutation site

JUN_HUMAN do not have mutation site.

Differential expressed protein

JUN_HUMAN is not differential expressed protein.

Hyperphosphorylation site

Site	Motif	Peptide	Cancer name	Pubmed	Source
S73	Jun	VGLLKLAsPELERLI	ovarian cancer	17001009	PhosphoSitePlus
S73	Jun	VGLLKLAsPELERLI	melanoma skin cancer	17001009	PhosphoSitePlus

Direct Interaction Pair

Source	Target	Relationship	Resource
CSK21_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
VRK1_HUMAN	JUN_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
MK01_HUMAN	JUN_HUMAN	kinase -> substrate	KEGG
MK08_HUMAN	JUN_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
ZAGL2_HUMAN	JUN_HUMAN	kinase -> substrate	RegPhos
ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
GSK3A_HUMAN	JUN_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
MK09_HUMAN	JUN_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
PRKDC_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD
MK08_HUMAN	JUN_HUMAN	other	KEGG
JUN_HUMAN	CCND1_HUMAN	other	KEGG
JUN_HUMAN	GROA_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	JUN_HUMAN	TF -> target gene	KEGG
JUN_HUMAN	IL8_HUMAN	TF -> target gene	KEGG
JUN_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
JUN_HUMAN	ARY1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	4F2_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	ANF_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	ITAX_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
SMAD4_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	UROK_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	P53_HUMAN	TF -> target gene	TRANSFAC
MEF2B_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	TNFA_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	IL2_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	MSH2_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	CXA1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	ATF3_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	MMP1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	EDN1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	LYAM2_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	K1C16_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	B2LA1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	TSHB_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	VIP_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	FINC_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	IL5_HUMAN	TF -> target gene	TRANSFAC
SMAD3_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	CCL5_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	MT2_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	HBB_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	MLTK_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05140	Leishmaniasis
hsa04620	Toll-like receptor signaling pathway
hsa05132	Salmonella infection
hsa05168	Herpes simplex infection
hsa05169	Epstein-Barr virus infection
hsa05164	Influenza A
hsa05133	Pertussis
hsa04010	MAPK signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04380	Osteoclast differentiation
hsa05142	Chagas disease (American trypanosomiasis)
hsa05120	Epithelial cell signaling in Helicobacter pylori i
hsa05166	HTLV-I infection
hsa05211	Renal cell carcinoma
hsa04510	Focal adhesion
hsa04912	GnRH signaling pathway
hsa04660	T cell receptor signaling pathway
hsa05200	Pathways in cancer
hsa04012	ErbB signaling pathway
hsa04310	Wnt signaling pathway
hsa05323	Rheumatoid arthritis
hsa05030	Cocaine addiction
hsa05031	Amphetamine addiction
hsa05203	Viral carcinogenesis
hsa05210	Colorectal cancer
hsa04662	B cell receptor signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0001525	angiogenesis	IEA	biological_process
GO:0045657	positive regulation of monocyte differentiation	IEA	biological_process
GO:0051403	stress-activated MAPK cascade	TAS	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pat	TAS	biological_process
GO:0060395	SMAD protein signal transduction	IDA	biological_process
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological_process
GO:0008285	negative regulation of cell proliferation	IEA	biological_process
GO:0071277	cellular response to calcium ion	IEA	biological_process
GO:0007568	aging	IEA	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathwa	TAS	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	TAS	biological_process
GO:0070412	R-SMAD binding	IPI	molecular_function
GO:0032496	response to lipopolysaccharide	IEA	biological_process
GO:0010033	response to organic substance	IEA	biological_process
GO:0006366	transcription from RNA polymerase II promoter	IEA	biological_process
GO:0043565	sequence-specific DNA binding	IEA	molecular_function
GO:0014070	response to organic cyclic compound	IEA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0035497	cAMP response element binding	IDA	molecular_function
GO:0051726	regulation of cell cycle	IEA	biological_process
GO:0043922	negative regulation by host of viral transcription	IDA	biological_process
GO:0044212	transcription regulatory region DNA binding	IEA	molecular_function
GO:0071837	HMG box domain binding	IEA	molecular_function
GO:0001774	microglial cell activation	IEA	biological_process
GO:0043923	positive regulation by host of viral transcription	IDA	biological_process
GO:0043065	positive regulation of apoptotic process	IEA	biological_process
GO:0042542	response to hydrogen peroxide	IEA	biological_process
GO:0001938	positive regulation of endothelial cell proliferat	IEA	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	IEA	molecular_function
GO:0009314	response to radiation	IEA	biological_process
GO:0009987	cellular process	IEA	biological_process
GO:0048146	positive regulation of fibroblast proliferation	IEA	biological_process
GO:0030224	monocyte differentiation	IEA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IC	biological_process
GO:0017053	transcriptional repressor complex	IEA	cellular_component
GO:0005515	protein binding	IEA	molecular_function
GO:0043392	negative regulation of DNA binding	IDA	biological_process
GO:0008134	transcription factor binding	IEA	molecular_function
GO:0003690	double-stranded DNA binding	IEA	molecular_function
GO:0051090	regulation of sequence-specific DNA binding transc	TAS	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathw	TAS	biological_process
GO:0034097	response to cytokine stimulus	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0003677	DNA binding	IEA	molecular_function
GO:0003713	transcription coactivator activity	IDA	molecular_function
GO:0031103	axon regeneration	IEA	biological_process
GO:0001077	RNA polymerase II core promoter proximal region se	IEA	molecular_function
GO:0002224	toll-like receptor signaling pathway	TAS	biological_process
GO:0051365	cellular response to potassium ion starvation	IEA	biological_process
GO:0032321	positive regulation of Rho GTPase activity	IDA	biological_process
GO:0001889	liver development	IEA	biological_process
GO:0031953	negative regulation of protein autophosphorylation	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0035026	leading edge cell differentiation	IEA	biological_process
GO:0043525	positive regulation of neuron apoptotic process	IEA	biological_process
GO:0006351	transcription, DNA-dependent	IEA	biological_process
GO:0007179	transforming growth factor beta receptor signaling	IDA	biological_process
GO:0008284	positive regulation of cell proliferation	IEA	biological_process
GO:0007612	learning	IEA	biological_process
GO:0001836	release of cytochrome c from mitochondria	IEA	biological_process
GO:0005667	transcription factor complex	IEA	cellular_component
GO:0045740	positive regulation of DNA replication	IEA	biological_process
GO:0006355	regulation of transcription, DNA-dependent	IEA	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	IDA	molecular_function
GO:0008063	Toll signaling pathway	TAS	biological_process
GO:0034138	toll-like receptor 3 signaling pathway	TAS	biological_process
GO:0001102	RNA polymerase II activating transcription factor	IPI	molecular_function
GO:0045892	negative regulation of transcription, DNA-dependen	IDA	biological_process
GO:0003705	RNA polymerase II distal enhancer sequence-specifi	IC	molecular_function
GO:0045893	positive regulation of transcription, DNA-dependen	IEA	biological_process
GO:0005100	Rho GTPase activator activity	IDA	molecular_function
GO:0045087	innate immune response	TAS	biological_process
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0034142	toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0003677	DNA binding	TAS	molecular_function
GO:0000228	nuclear chromosome	TAS	cellular_component
GO:0009612	response to mechanical stimulus	IEA	biological_process
GO:0048661	positive regulation of smooth muscle cell prolifer	IEA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005719	nuclear euchromatin	IDA	cellular_component
GO:0051899	membrane depolarization	IEA	biological_process
GO:0051591	response to cAMP	IEA	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0008134	transcription factor binding	IPI	molecular_function
GO:0043066	negative regulation of apoptotic process	IEA	biological_process
GO:0003151	outflow tract morphogenesis	IEA	biological_process
GO:0007623	circadian rhythm	IEA	biological_process
GO:0000980	RNA polymerase II distal enhancer sequence-specifi	IDA	molecular_function
GO:0001190	RNA polymerase II transcription factor binding tra	IC	molecular_function
GO:0034130	toll-like receptor 1 signaling pathway	TAS	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0007184	SMAD protein import into nucleus	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network