Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MEF2C_HUMAN
Description:myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:6996]
Location:chr5 q14.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T293AQSLAtPVVSVp38a(MAPK14RegPhos
S396KSEPVsPPRDRP14635(Cyclin B1RegPhos
S240NMQAKsPPPMNPhosphoSitePlus; HPRD
S192THRPPsAGNTGRSK-2phosphoELM
T293AQSLAtPVVSVMAPK14HPRD; phosphoELM
S59LFQYAsTDMDKCSNK2A1HPRD
T293AQSLAtPVVSVp38aRegPhos
S461ERESPsVKRMRPhosphoSitePlus
S396KSEPVsPPRDRCDK1HPRD
T87SDIVEtLRKKGPhosphoSitePlus
S387LPSTQsLNIKSErk5(MAPK7RegPhos
S387LPSTQsLNIKSp38aRegPhos
T300VVSVAtPTLPGMAPK14HPRD; phosphoELM
S110DSVGHsPESEDHJURP_CPhosphoSitePlus
S387LPSTQsLNIKSErk5RegPhos
T80PHESRtNSDIVPhosphoSitePlus
S106PDADDsVGHSPHJURP_CPhosphoSitePlus
S387LPSTQsLNIKSMAPK7HPRD; phosphoELM
S387LPSTQsLNIKSMAPK14HPRD
T300VVSVAtPTLPGp38a(MAPK14RegPhos
S387LPSTQsLNIKSMAPK_groupphosphoELM; RegPhos
S396KSEPVsPPRDRCCNB1HPRD
T300VVSVAtPTLPGp38aRegPhos
S396KSEPVsPPRDRCDC2RegPhos
S82ESRTNsDIVETPhosphoSitePlus
S98LNGCDsPDPDAHJURP_CPhosphoSitePlus
S59LFQYAsTDMDKCK2_groupphosphoELM; RegPhos
S222GNPRNsPGLLVPhosphoSitePlus; HPRD
S59LFQYAsTDMDKCK2a1RegPhos
S396KSEPVsPPRDRPhosphoSitePlus; phosphoELM; RegPhos
S59LFQYAsTDMDKCK2a1-rsRegPhos

Dephosphorylation site
MEF2C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000422390V290IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000396219E442KCOSMICLung Cancer
ENSP00000426665S110CCOSMICLung Cancer20668451
ENSP00000396219*474GCOSMICOvarian Cancer21720365
ENSP00000396219K90NCOSMICHead and Neck Cancer21798893
ENSP00000426665M127ICOSMICHead and Neck Cancer21798893
ENSP00000426665G215RCOSMICIntestines Cancer17932254
ENSP00000426665*474GCOSMICOvarian Cancer21720365
ENSP00000396219C41SCOSMICHead and Neck Cancer21798893
ENSP00000426665E74KCOSMICHead and Neck Cancer21798893
ENSP00000396219G215RCOSMICIntestines Cancer17932254
ENSP00000426665D432YCOSMICOvarian Cancer21720365
ENSP00000426665P294QCOSMICLung Cancer20668451
ENSP00000426665M29ICOSMICBreast Cancer20668451
ENSP00000396219E74KCOSMICHead and Neck Cancer21798893
ENSP00000426665C41SCOSMICHead and Neck Cancer21798893
ENSP00000396219M127ICOSMICHead and Neck Cancer21798893
ENSP00000396219P294QCOSMICLung Cancer20668451
ENSP00000396219V298IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000426665K90NCOSMICHead and Neck Cancer21798893
ENSP00000396219R189*COSMICBreast Cancer17932254
ENSP00000426665E442KCOSMICLung Cancer
ENSP00000396219S110CCOSMICLung Cancer20668451
ENSP00000426665V298IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000426665R189*COSMICBreast Cancer17932254
ENSP00000396219M29ICOSMICBreast Cancer20668451
ENSP00000424606V298IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000396219D432YCOSMICOvarian Cancer21720365

Differential expressed protein
MEF2C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MEF2C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK07_HUMANMEF2C_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
AKT1_HUMANMEF2C_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMEF2C_HUMANkinase -> substrateHPRD
CDK1_HUMANMEF2C_HUMANkinase -> substrateHPRD; RegPhos
CCNB1_HUMANMEF2C_HUMANkinase -> substrateHPRD
ZAGL2_HUMANMEF2C_HUMANkinase -> substrateRegPhos
MK14_HUMANMEF2C_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030501positive regulation of bone mineralizationIEAbiological_process
GO:0002467germinal center formationIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0003211cardiac ventricle formationIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0030318melanocyte differentiationIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:2000111positive regulation of macrophage apoptotic procesIEAbiological_process
GO:0009615response to virusIEPbiological_process
GO:0035198miRNA bindingIDAmolecular_function
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0007517muscle organ developmentTASbiological_process
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:2001013epithelial cell proliferation involved in renal tuIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0001046core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0016607nuclear speckIDAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0007521muscle cell fate determinationIEAbiological_process
GO:0055012ventricular cardiac muscle cell differentiationISSbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0030182neuron differentiationISSbiological_process
GO:0007507heart developmentISSbiological_process
GO:0021542dentate gyrus developmentIEAbiological_process
GO:0001958endochondral ossificationIEAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIEAmolecular_function
GO:2001016positive regulation of skeletal muscle cell differIDAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0061333renal tubule morphogenesisISSbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trISSmolecular_function
GO:0042100B cell proliferationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0000983RNA polymerase II core promoter sequence-specific IDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:2000987positive regulation of behavioral fear responseIEAbiological_process
GO:0045652regulation of megakaryocyte differentiationIEAbiological_process
GO:0061337cardiac conductionIEAbiological_process
GO:0048311mitochondrion distributionIEAbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0035984cellular response to trichostatin AIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0048643positive regulation of skeletal muscle tissue deveIMPbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0071374cellular response to parathyroid hormone stimulusIDAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0060297regulation of sarcomere organizationIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0042826histone deacetylase bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0014898cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0048703embryonic viscerocranium morphogenesisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0071560cellular response to transforming growth factor beIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0033197response to vitamin EIEAbiological_process
GO:0033613activating transcription factor bindingIEAmolecular_function
GO:0006366transcription from RNA polymerase II promoterISSbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0003185sinoatrial valve morphogenesisIEAbiological_process
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0090073positive regulation of protein homodimerization acIEAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0072102glomerulus morphogenesisIEAbiological_process
GO:0002634regulation of germinal center formationIEAbiological_process
GO:0010694positive regulation of alkaline phosphatase activiIEAbiological_process
GO:0014902myotube differentiationIEPbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0042692muscle cell differentiationTASbiological_process
GO:0072160nephron tubule epithelial cell differentiationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0071277cellular response to calcium ionIEAbiological_process
GO:2000727positive regulation of cardiac muscle cell differeIEAbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0071498cellular response to fluid shear stressIEAbiological_process
GO:0060536cartilage morphogenesisIEAbiological_process
GO:0030279negative regulation of ossificationIDAbiological_process
GO:0000002mitochondrial genome maintenanceIEAbiological_process
GO:0007519skeletal muscle tissue developmentISSbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0014033neural crest cell differentiationIEAbiological_process
GO:0030224monocyte differentiationIEAbiological_process
GO:0055012ventricular cardiac muscle cell differentiationIEAbiological_process
GO:0035914skeletal muscle cell differentiationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0045663positive regulation of myoblast differentiationIMPbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0035690cellular response to drugIEAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0003138primary heart field specificationIEAbiological_process
GO:0003139secondary heart field specificationIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingISSmolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0030220platelet formationIEAbiological_process
GO:0055005ventricular cardiac myofibril developmentIEAbiological_process
GO:0071864positive regulation of cell proliferation in bone IEAbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0048666neuron developmentIEAbiological_process
GO:0060025regulation of synaptic activityIEAbiological_process
GO:0006959humoral immune responseIEAbiological_process
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0003680AT DNA bindingIDAmolecular_function
GO:0051403stress-activated MAPK cascadeTASbiological_process