Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WASP_HUMAN
Description:Wiskott-Aldrich syndrome [Source:HGNC Symbol;Acc:12731]
Location:chrX p11.23
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S287TDAETsKLIYDPBDPhosphoSitePlus
S483SRAIHsSDEGEPhosphoSitePlus; phosphoELM
T282SEAQLtDAETSPBDPhosphoSitePlus
Y291TSKLIyDFIEDBTKHPRD; phosphoELM; RegPhos; SysPTM
T286LTDAEtSKLIYPBDPhosphoSitePlus
S277SRAGIsEAQLTPBDPhosphoSitePlus
Y291TSKLIyDFIEDPBDPhosphoSitePlus; SysPTM
S320PPPPPsRGGNQPhosphoSitePlus
S484RAIHSsDEGEDCK2_groupRegPhos
S484RAIHSsDEGEDCK2a1(CK2 alphaRegPhos
S483SRAIHsSDEGECK2a1RegPhos
S483SRAIHsSDEGECK2a2RegPhos
S484RAIHSsDEGEDCK2a2RegPhos
Y291TSKLIyDFIEDphosphoELM; RegPhos; SysPTM
S484RAIHSsDEGEDCK2a1-rsRegPhos
S483SRAIHsSDEGECK2_groupRegPhos
T355APPPPtPRGPPPhosphoSitePlus; HPRD
Y291TSKLIyDFIEDHCKHPRD; phosphoELM; RegPhos; SysPTM
S484RAIHSsDEGEDCK2_alphaphosphoELM
S483SRAIHsSDEGECSNK2A1HPRD
Y83NPQKSyFIRLYWH1PhosphoSitePlus
S484RAIHSsDEGEDCSNK2A2HPRD
S484RAIHSsDEGEDCSNK2A1HPRD
S221PAPGPsPADKKPhosphoSitePlus
S483SRAIHsSDEGECK2a1-rsRegPhos
S484RAIHSsDEGEDCK2a1RegPhos
S483SRAIHsSDEGECSNK2A2HPRD
S484RAIHSsDEGEDPhosphoSitePlus; phosphoELM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y291AETSKLIyDFIEDQGPTPN12HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365891P417SCOSMICOvarian Cancer21720365
ENSP00000365891P417STCGAOvarian Cancer21720365, 18772890

Differential expressed protein
WASP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WASP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANWASP_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANWASP_HUMANkinase -> substrateNetPath
CSK22_HUMANWASP_HUMANkinase -> substrateHPRD
ZAGL2_HUMANWASP_HUMANkinase -> substrateRegPhos
BTK_HUMANWASP_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CSK21_HUMANWASP_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PTN12_HUMANWASP_HUMANphosphatase -> substrateHPRD; NetPath
WASP_HUMANARPC5_HUMANotherKEGG
CDC42_HUMANWASP_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection
hsa05131Shigellosis
hsa04666Fc gamma R-mediated phagocytosis
hsa05130Pathogenic Escherichia coli infection
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042110T cell activationIEAbiological_process
GO:0016197endosomal transportIEAbiological_process
GO:0012506vesicle membraneIEAcellular_component
GO:0008154actin polymerization or depolymerizationIEAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0008544epidermis developmentTASbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0006952defense responseTASbiological_process
GO:0030041actin filament polymerizationIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0006955immune responseIMPbiological_process
GO:0015629actin cytoskeletonIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0008154actin polymerization or depolymerizationTASbiological_process
GO:0030048actin filament-based movementIEAbiological_process


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