Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PI42A_HUMAN
Description:phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [Source:HGNC Symbol;Acc:8997]
Location:chr10 p12.2
Node attribute:Enzyme(source); substrate; Enzyme(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S304EEEGEsDGTHPCK2_alphaphosphoELM
S14SSVLAsKTKTKPhosphoSitePlus; HPRD; SysPTM
S9PGNLGsSVLASHPRD
Y246EGQKIyIDDNNPIP5KPhosphoSitePlus
T3GNLGHPRD; SysPTM
S304EEEGEsDGTHPPIP5KPhosphoSitePlus
T3___MAtPGNLGPhosphoSitePlus; SysPTM
S10GNLGSsVLASKPhosphoSitePlus
T376AHAAKtVKHGAPIP5KPhosphoSitePlus
Y93FKFKEyCPMVFPhosphoSitePlus; phosphoELM
S304EEEGEsDGTHPCK2a1(CK2 alphaRegPhos

Dephosphorylation site
PI42A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365757I401NCOSMICOvarian Cancer21720365
ENSP00000365757P325SCOSMICMelanoma

Differential expressed protein
PI42A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PI42A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANPI42A_HUMANkinase -> substrateRobert H Newman (2013)
FYV1_HUMANPI42A_HUMANenzyme catalysisKEGG
I5P2_HUMANPI42A_HUMANenzyme catalysisKEGG
PLCD3_HUMANPI42A_HUMANenzyme catalysisKEGG
PI42A_HUMANPTEN_HUMANenzyme catalysisKEGG
PI3R5_HUMANPI42A_HUMANenzyme catalysisKEGG
PI51C_HUMANPI42A_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016307phosphatidylinositol phosphate kinase activityIEAmolecular_function
GO:0016310phosphorylationNASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activiIEAmolecular_function
GO:0035855megakaryocyte developmentIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005575cellular_componentNDcellular_component
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activiNASmolecular_function
GO:0046488phosphatidylinositol metabolic processIEAbiological_process


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