| UniProt/SwissProt ID: | PI42A_HUMAN |
| Description: | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [Source:HGNC Symbol;Acc:8997] |
| Location: | chr10 p12.2 |
| Node attribute: | Enzyme(source); substrate; Enzyme(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S304 | EEEGEsDGTHP | CK2_alpha | phosphoELM |
| S14 | SSVLAsKTKTK | PhosphoSitePlus; HPRD; SysPTM | |
| S9 | PGNLGsSVLAS | HPRD | |
| Y246 | EGQKIyIDDNN | PIP5K | PhosphoSitePlus |
| T3 | GNLG | HPRD; SysPTM | |
| S304 | EEEGEsDGTHP | PIP5K | PhosphoSitePlus |
| T3 | ___MAtPGNLG | PhosphoSitePlus; SysPTM | |
| S10 | GNLGSsVLASK | PhosphoSitePlus | |
| T376 | AHAAKtVKHGA | PIP5K | PhosphoSitePlus |
| Y93 | FKFKEyCPMVF | PhosphoSitePlus; phosphoELM | |
| S304 | EEEGEsDGTHP | CK2a1(CK2 alpha | RegPhos |
| Dephosphorylation site |
| PI42A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365757 | I401N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000365757 | P325S | COSMIC | Melanoma |
| Differential expressed protein |
| PI42A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PI42A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | PI42A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FYV1_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
| I5P2_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
| PLCD3_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
| PI42A_HUMAN | PTEN_HUMAN | enzyme catalysis | KEGG |
| PI3R5_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00562 | Inositol phosphate metabolism |
| hsa04070 | Phosphatidylinositol signaling system |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016307 | phosphatidylinositol phosphate kinase activity | IEA | molecular_function |
| GO:0016310 | phosphorylation | NAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activi | IEA | molecular_function |
| GO:0035855 | megakaryocyte development | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activi | NAS | molecular_function |
| GO:0046488 | phosphatidylinositol metabolic process | IEA | biological_process |