| UniProt/SwissProt ID: | GBRR1_HUMAN |
| Description: | gamma-aminobutyric acid (GABA) A receptor, rho 1 [Source:HGNC Symbol;Acc:4090] |
| Location: | chr6 q15 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S166 | VHSKRsFIHDT | Neur_chan_LBD | PhosphoSitePlus |
| T394 | LPPPRtAMLDG | MAPK1 | HPRD |
| S431 | QLTLAsERSSP | PRKCA | HPRD |
| Y219 | LEIESyAYTED | Neur_chan_LBD | PhosphoSitePlus |
| S435 | ASERSsPQRKS | MAPK1 | HPRD |
| S444 | KSQRSsYVSMR | PRKG1 | HPRD |
| Y221 | IESYAyTEDDL | Neur_chan_LBD | PhosphoSitePlus |
| Y229 | DDLMLyWKKGN | Neur_chan_LBD | PhosphoSitePlus |
| S440 | SPQRKsQRSSY | MAPK1 | HPRD |
| S447 | RSSYVsMRIDT | PRKCA | HPRD |
| S402 | LDGNYsDGEVN | CSNK2A1 | HPRD |
| S443 | RKSQRsSYVSM | PRKCA | HPRD |
| T171 | SFIHDtTTDNV | Neur_chan_LBD | PhosphoSitePlus |
| S440 | SPQRKsQRSSY | PRKCA | HPRD |
| S444 | KSQRSsYVSMR | PRKACA | HPRD |
| S443 | RKSQRsSYVSM | HPRD | |
| T172 | FIHDTtTDNVM | Neur_chan_LBD | PhosphoSitePlus |
| S444 | KSQRSsYVSMR | PRKCA | HPRD |
| Dephosphorylation site |
| GBRR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000412673 | D66E | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GBRR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GBRR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | GBRR1_HUMAN | kinase -> substrate | HPRD |
| KGP1_HUMAN | GBRR1_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | GBRR1_HUMAN | kinase -> substrate | HPRD |
| MK01_HUMAN | GBRR1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa04727 | GABAergic synapse |
| hsa05033 | Nicotine addiction |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa05032 | Morphine addiction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034707 | chloride channel complex | IEA | cellular_component |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0004890 | GABA-A receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0006810 | transport | TAS | biological_process |
| GO:0034220 | ion transmembrane transport | TAS | biological_process |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | TAS | biological_process |
| GO:0005254 | chloride channel activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | molecular_function |
| GO:0006811 | ion transport | IEA | biological_process |