Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STMN1_HUMAN
Description:stathmin 1 [Source:HGNC Symbol;Acc:6510]
Location:chr1 p36.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S16LEKRAsGQAFECK2a1RegPhos; SysPTM
T146DPADEtEAD__CDC37_NPhosphoSitePlus; SysPTM
S25FELILsPRSKEMAPK3HPRD; SysPTM
S38PEFPLsPPKKKMAPK_groupphosphoELM; SysPTM
S63EERRKsHEAEVPKACaRegPhos; SysPTM
S28ILSPRsKESVPStathminPhosphoSitePlus
S16LEKRAsGQAFEPAK1phosphoELM; RegPhos; SysPTM
T146DPADEtEHPRD; phosphoELM; SysPTM
S25FELILsPRSKEMAPK_groupphosphoELM; RegPhos; SysPTM
S31PRSKEsVPEFPStathminPhosphoSitePlus
S38PEFPLsPPKKKCDK1HPRD; SysPTM
S38PEFPLsPPKKKPKCb(PKC betaRegPhos; SysPTM
T102AEEKLtHKMEAStathmin; CDC37_NPhosphoSitePlus
S16LEKRAsGQAFECSNK2A1HPRD; SysPTM
S28ILSPRsKESVPHPRD; phosphoELM; RegPhos
S25FELILsPRSKECDC2RegPhos; SysPTM
S16LEKRAsGQAFECK2a1-rsRegPhos; SysPTM
S63EERRKsHEAEVCSNK2A1HPRD; SysPTM
S25FELILsPRSKEStathminPhosphoSitePlus; SysPTM
S16LEKRAsGQAFEPKACaRegPhos; SysPTM
S25FELILsPRSKECDK1HPRD; SysPTM
S38PEFPLsPPKKKp38d(MAPK13RegPhos; SysPTM
T102AEEKLtHKMEAHPRD
S38PEFPLsPPKKKMAPK13phosphoELM; SysPTM
S38PEFPLsPPKKKStathmin; CDC37_NPhosphoSitePlus; SysPTM
S63EERRKsHEAEVCK2a1-rsRegPhos; SysPTM
S63EERRKsHEAEVHPRD; phosphoELM; SysPTM
S38PEFPLsPPKKKCDK_groupphosphoELM; RegPhos; SysPTM
S25FELILsPRSKEp38d(MAPK13RegPhos; SysPTM
S31PRSKEsVPEFPHPRD
S25FELILsPRSKEHPRD; phosphoELM; SysPTM
S25FELILsPRSKEMAPK13phosphoELM; SysPTM
S63EERRKsHEAEVCK2a1RegPhos; SysPTM
S38PEFPLsPPKKKHPRD; phosphoELM; SysPTM
S46KKKDLsLEEIQHPRD; RegPhos; SysPTM
S38PEFPLsPPKKKCDC2RegPhos; SysPTM
S16LEKRAsGQAFEStathminPhosphoSitePlus; SysPTM
S63EERRKsHEAEVStathmin; CDC37_NPhosphoSitePlus; SysPTM
T146DPADEtEADRegPhos; SysPTM
S16LEKRAsGQAFEHPRD; phosphoELM; RegPhos; SysPTM
S63EERRKsHEAEVPRKACAHPRD; SysPTM
S25FELILsPRSKEErk1RegPhos; SysPTM
S46KKKDLsLEEIQStathmin; CDC37_NPhosphoSitePlus; SysPTM
S63EERRKsHEAEVPKA_groupphosphoELM; RegPhos; SysPTM
S16LEKRAsGQAFEPRKACAHPRD; SysPTM
S25FELILsPRSKEPKCb(PKC betaRegPhos; SysPTM

Dephosphorylation site
STMN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382633*150LCOSMICHead and Neck Cancer21798893
ENSP00000350531*150LCOSMICHead and Neck Cancer21798893
ENSP00000387858*150LCOSMICHead and Neck Cancer21798893
ENSP00000363409*150LCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000382633Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000382633Hepatocellular CarcinomaNormal vs. CancertissueUp1115759316
ENSP00000382633LeukemiaNormal vs. Cancercell lineDown0.2217022645
ENSP00000382633LeukemiaNormal vs. Cancercell lineDown0.3817022645
ENSP00000382633Hepatocellular CarcinomaMetastasiscell lineUp1.719016532
ENSP00000382633Neoplasms by Histologic TypeNormal vs. CancertissueUp312874873
ENSP00000382633Brain CancerCancer vs. Cancercell lineDown15750928
ENSP00000382633Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000382633Breast CancerMetastasiscell lineUp20155427
ENSP00000382633LeukemiaNormal vs. CancertissueUp15501966
ENSP00000382633LeukemiaCancer vs. Cancer (subtype)tissueUp15501966
ENSP00000382633Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp2.521080034
ENSP00000382633Esophageal CancerNormal vs. Cancercell lineDown0.4519090015
ENSP00000382633Esophageal CancerNormal vs. Cancercell lineDown0.4819090015
ENSP00000382633Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineDown0.4220944110

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S25StathminQAFELILsPRSKESVAlzheimer's disease; schizophrenia16925597PhosphoSitePlus
S38Stathmin; CDC37_NSVPEFPLsPPKKKDLAlzheimer's disease; schizophrenia16925597PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANSTMN1_HUMANkinase -> substrateHPRD
KPCA_HUMANSTMN1_HUMANkinase -> substrateHPRD
PKN1_HUMANSTMN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANSTMN1_HUMANkinase -> substrateRegPhos
MK13_HUMANSTMN1_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANSTMN1_HUMANkinase -> substrateRegPhos
MK01_HUMANSTMN1_HUMANkinase -> substrateKEGG
CSK21_HUMANSTMN1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0035556intracellular signal transductionTASbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0051272positive regulation of cellular component movementIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005622intracellularIDAcellular_component
GO:0009615response to virusIEPbiological_process
GO:0031110regulation of microtubule polymerization or depolyIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007019microtubule depolymerizationIDAbiological_process
GO:0031115negative regulation of microtubule polymerizationIEAbiological_process
GO:0007052mitotic spindle organizationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0015631tubulin bindingIDAmolecular_function
GO:0007165signal transductionNASbiological_process


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