Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARRB2_HUMAN
Description:arrestin, beta 2 [Source:HGNC Symbol;Acc:712]
Location:chr17 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T382DTNYAtDDDIVCK2_groupphosphoELM; RegPhos
T382DTNYAtDDDIVCK2_alphaphosphoELM
S13RVFKKsSPNCKPhosphoSitePlus
S159SLEEKsHKRNSArrestin_NPhosphoSitePlus
T20PNCKLtVYLGKArrestin_NPhosphoSitePlus
T382DTNYAtDDDIVPhosphoSitePlus
T382DTNYAtDDDIVCK2a1(CK2 alphaRegPhos
S14VFKKSsPNCKLPhosphoSitePlus
Y48LVDPDyLKDRKRegPhos
T382DTNYAtDDDIVCK2a1-rsRegPhos
T382DTNYAtDDDIVCSNK2A2HPRD
T382DTNYAtDDDIVCSNK2A1HPRD
Y404MKDDDyDDQLCPhosphoSitePlus
T382DTNYAtDDDIVCK2a2RegPhos
T382DTNYAtDDDIVCK2a1RegPhos
Y48LVDPDyLKDRKArrestin_NPhosphoSitePlus

Dephosphorylation site
ARRB2_HUMAN do not have dephosphorylation site.

Mutation site
ARRB2_HUMAN do not have mutation site.

Differential expressed protein
ARRB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARRB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANARRB2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANARRB2_HUMANkinase -> substrateRegPhos
CSK21_HUMANARRB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05032Morphine addiction
hsa04744Phototransduction
hsa04010MAPK signaling pathway
hsa04144Endocytosis
hsa04062Chemokine signaling pathway
hsa04740Olfactory transduction
hsa04728Dopaminergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0002092positive regulation of receptor internalizationIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0002031G-protein coupled receptor internalizationIDAbiological_process
GO:0045953negative regulation of natural killer cell mediateIMPbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0034260negative regulation of GTPase activityIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0060765regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0043422protein kinase B bindingIEAmolecular_function
GO:0016567protein ubiquitinationIMPbiological_process
GO:0032947protein complex scaffoldIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0031748D1 dopamine receptor bindingIEAmolecular_function
GO:0034392negative regulation of smooth muscle cell apoptotiIEAbiological_process
GO:0031692alpha-1B adrenergic receptor bindingIEAmolecular_function
GO:0005905coated pitIEAcellular_component
GO:0032715negative regulation of interleukin-6 productionIEAbiological_process
GO:0051928positive regulation of calcium ion transportIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0031826type 2A serotonin receptor bindingIEAmolecular_function
GO:0005102receptor bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0032691negative regulation of interleukin-1 beta productiIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0001664G-protein coupled receptor bindingIPImolecular_function
GO:0007628adult walking behaviorIEAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0042699follicle-stimulating hormone signaling pathwayIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0050965detection of temperature stimulus involved in sensIEAbiological_process
GO:0032226positive regulation of synaptic transmission, dopaIEAbiological_process
GO:0032720negative regulation of tumor necrosis factor produIEAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0031397negative regulation of protein ubiquitinationIEAbiological_process
GO:0008277regulation of G-protein coupled receptor protein sIEAbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007219Notch signaling pathwayTASbiological_process
GO:0060326cell chemotaxisIMPbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0031398positive regulation of protein ubiquitinationIGIbiological_process
GO:0032695negative regulation of interleukin-12 productionIEAbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic IMPbiological_process
GO:0031702type 1 angiotensin receptor bindingIEAmolecular_function
GO:0002032desensitization of G-protein coupled receptor protIMPbiological_process
GO:0031701angiotensin receptor bindingIPImolecular_function
GO:0031762follicle-stimulating hormone receptor bindingIEAmolecular_function
GO:0031691alpha-1A adrenergic receptor bindingIEAmolecular_function
GO:0031623receptor internalizationIDAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0031397negative regulation of protein ubiquitinationIDAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0007179transforming growth factor beta receptor signalingIDAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0034122negative regulation of toll-like receptor signalinIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051019mitogen-activated protein kinase bindingIEAmolecular_function