| UniProt/SwissProt ID: | ASAP3_HUMAN |
| Description: | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [Source:HGNC Symbol;Acc:14987] |
| Location: | chr1 p36.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y535 | YIMAKyVEHRF | ArfGap | PhosphoSitePlus |
| Y76 | ENEEQyREAVE | PhosphoSitePlus | |
| Y843 | TPSEMyLPVRF | PhosphoSitePlus | |
| Y530 | GTRRDyIMAKY | ArfGap | PhosphoSitePlus |
| S286 | LSRKNsGCGYS | PhosphoSitePlus | |
| Y733 | ISNKTyETVAS | PhosphoSitePlus | |
| Dephosphorylation site |
| ASAP3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000338769 | S125C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000338769 | P516L | COSMIC | Melanoma | 21499247 | ENSP00000408826 | S125C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000338769 | A617T | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000338769 | A617T | HPI | Colorectal Cancer | 16959974 |
| Differential expressed protein |
| ASAP3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ASAP3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK4_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK2_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK2_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1E_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK21_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMX_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCI_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK9_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK10_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K7_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAF1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC1D_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK25_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK24_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1G1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK2_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A5_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WNK1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DDR1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FYN_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1AL_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AVR2B_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAST1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1A_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK4_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| YES_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ASAP3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008060 | ARF GTPase activator activity | IEA | molecular_function |
| GO:0032312 | regulation of ARF GTPase activity | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |