Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NUAK1_HUMAN
Description:NUAK family, SNF1-like kinase, 1 [Source:HGNC Symbol;Acc:14311]
Location:chr12 q23.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S445VLLPSsPEAEVPhosphoSitePlus
Y141SKGELyDYISEPkinase; YukCPhosphoSitePlus
S371RSLKKsKKENDRegPhos
S600RQRIRsCVSAEAKT1(PKBRegPhos
S215QTFCGsPLYASRegPhos
S516RVTSHsLSCRRPhosphoSitePlus
S455VPGKLsPKQSAPhosphoSitePlus
S600RQRIRsCVSAEPKB_groupphosphoELM
T211DKFLQtFCGSPPkinasePhosphoSitePlus
S145LYDYIsERRRLPkinase; YukCPhosphoSitePlus
S499NDVMGsSIPSPPhosphoSitePlus
S388DAVPEsPSKLSPhosphoSitePlus
Y565GLSRSySRPSSHPRD
T211DKFLQtFCGSPRegPhos
S562PAEGLsRSYSRPhosphoSitePlus
S518TSHSLsCRRKGPhosphoSitePlus
T211DKFLQtFCGSPLKB1phosphoELM
S380NDFAQsGQDAVRegPhos
S22LGAPGsPREAVPhosphoSitePlus
T356GLAKPtTSEVMPhosphoSitePlus
S564EGLSRsYSRPSPhosphoSitePlus; HPRD
S600RQRIRsCVSAEPhosphoSitePlus; phosphoELM
S600RQRIRsCVSAEAKT_groupRegPhos
Y143GELYDyISERRPkinase; YukCPhosphoSitePlus
T211DKFLQtFCGSPLKB1(STK11RegPhos

Dephosphorylation site
NUAK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261402R404QCOSMICMelanoma21499247
ENSP00000261402R364QCOSMICOvarian Cancer21720365

Differential expressed protein
NUAK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NUAK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK11_HUMANNUAK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCT_HUMANNUAK1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANNUAK1_HUMANkinase -> substrateRegPhos
NUAK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANNUAK1_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANCASP6_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANNUAK1_HUMANkinase -> substrateRegPhos
NUAK1_HUMANCDKA1_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMAN2AAB_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NUAK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0002039p53 bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0042127regulation of cell proliferationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0030155regulation of cell adhesionIDAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:2000772regulation of cellular senescenceIDAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0035507regulation of myosin-light-chain-phosphatase activIDAbiological_process