| UniProt/SwissProt ID: | SPIB_HUMAN |
| Description: | Transcription factor Spi-B [Source:UniProtKB/Swiss-Prot;Acc:Q01892] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S146 | LEVSDsESDEA | CK2a1-rs | RegPhos |
| S37 | SSYPDsEGAPD | CK2a1-rs | RegPhos |
| S146 | LEVSDsESDEA | CK2a2 | RegPhos |
| S37 | SSYPDsEGAPD | CK2_group | phosphoELM; RegPhos |
| S144 | PALEVsDSESD | CK2a1-rs | RegPhos |
| S146 | LEVSDsESDEA | CK2a1 | RegPhos |
| S146 | LEVSDsESDEA | CK2_group | phosphoELM; RegPhos |
| S129 | PSPVLsEEEDL | CK2a1-rs | RegPhos |
| S144 | PALEVsDSESD | CK2a2 | RegPhos |
| S144 | PALEVsDSESD | CK2a1 | RegPhos |
| S37 | SSYPDsEGAPD | CK2a1 | RegPhos |
| T56 | PPVPAtPYEAF | Erk1 | RegPhos |
| S37 | SSYPDsEGAPD | CK2a2 | RegPhos |
| T56 | PPVPAtPYEAF | MAPK3 | phosphoELM |
| S129 | PSPVLsEEEDL | CK2a2 | RegPhos |
| S129 | PSPVLsEEEDL | CK2a1 | RegPhos |
| T56 | PPVPAtPYEAF | Erk1(MAPK3 | RegPhos |
| S144 | PALEVsDSESD | CK2_group | phosphoELM; RegPhos |
| S129 | PSPVLsEEEDL | CK2_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| SPIB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000270632 | E162* | COSMIC | Renal Cancer | 20054297 |
| Differential expressed protein |
| SPIB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPIB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK22_HUMAN | SPIB_HUMAN | kinase -> substrate | HPRD |
| MK03_HUMAN | SPIB_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| CSK21_HUMAN | SPIB_HUMAN | kinase -> substrate | HPRD |
| PRDM1_HUMAN | SPIB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SPIB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |