Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF2B_HUMAN
Description:eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa [Source:HGNC Symbol;Acc:3266]
Location:chr20 q11.22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y176ERDYTyEELLNPhosphoSitePlus; SysPTM
S2____MsGDEMIPhosphoSitePlus; SysPTM
Y298KDTRLyFLQCEeIF-5_eIF-2BPhosphoSitePlus
S2DEMICSNK2A1HPRD; SysPTM
T36TQTEEtQPSETPhosphoSitePlus
T11MIFDPtMSKKKHPRD; SysPTM
S67RKKDAsDDLDDCSNK2A1HPRD; SysPTM
S2MSGDEmICK2a1-rsRegPhos; SysPTM
S67RKKDAsDDLDDCK2a1RegPhos; SysPTM
T111DVQEPtEPEDDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T31DEEGDtQTEETPhosphoSitePlus; HPRD
S67RKKDAsDDLDDCK2a1-rsRegPhos; SysPTM
S13FDPTMsKKKKKHPRD; RegPhos; SysPTM
S67RKKDAsDDLDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S2MSGDEmICK2a1RegPhos; SysPTM
S2DEMIphosphoELM; SysPTM
S218GTKKTsFVNFTeIF-5_eIF-2BPhosphoSitePlus
S218GTKKTsFVNFTHPRD; RegPhos
S105DLKIEsDVQEPPhosphoSitePlus; HPRD; phosphoELM
S2MSGDEmIRegPhos; SysPTM
S158KDDGIsFSNQTPhosphoSitePlus; HPRD

Dephosphorylation site
IF2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364119K21delBIOMARTColorectal Cancer21930507, 21930502
ENSP00000364119K21-Sjoblom2006Intestines Cancer16959974
ENSP00000364119R231CCOSMICHead and Neck Cancer21798893

Differential expressed protein
IF2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IF2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANIF2B_HUMANkinase -> substrateRegPhos
CSK21_HUMANIF2B_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006412translationTASbiological_process
GO:0003723RNA bindingTASmolecular_function
GO:0006413translational initiationTASbiological_process
GO:0008135translation factor activity, nucleic acid bindingTASmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005850eukaryotic translation initiation factor 2 complexTAScellular_component
GO:0003743translation initiation factor activityIDAmolecular_function


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