UniProt/SwissProt ID: | MYCN_HUMAN |
Description: | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) [Source:HGNC Symbol;Acc:7559] |
Location: | chr2 p24.3 |
Node attribute: | substrate |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
T58 | FELLPtPPLSP | Myc_N | PhosphoSitePlus |
T58 | FELLPtPPLSP | HPRD; phosphoELM; RegPhos | |
S261 | GEDTLsDSDDE | CSNK2A1 | HPRD |
S261 | GEDTLsDSDDE | CSNK2A2 | HPRD |
S261 | GEDTLsDSDDE | Myc_N; LRS4; BSP_II; Cenp | PhosphoSitePlus |
S263 | DTLSDsDDEDD | CSNK2A2 | HPRD |
S263 | DTLSDsDDEDD | CSNK2A1 | HPRD |
S261 | GEDTLsDSDDE | CK2_alpha | phosphoELM |
S62 | PTPPLsPSRGF | HPRD; phosphoELM; RegPhos | |
S261 | GEDTLsDSDDE | CK2a1-rs | RegPhos |
S62 | PTPPLsPSRGF | Myc_N | PhosphoSitePlus |
S261 | GEDTLsDSDDE | CK2_group | phosphoELM; RegPhos |
S263 | DTLSDsDDEDD | CK2a1-rs | RegPhos |
S263 | DTLSDsDDEDD | CK2a1(CK2 alpha | RegPhos |
S5 | STMP | phosphoELM | |
S263 | DTLSDsDDEDD | Myc_N; LRS4; BSP_II; Cenp | PhosphoSitePlus |
S156 | GAGAAsPAGRG | Myc_N | PhosphoSitePlus |
S263 | DTLSDsDDEDD | CK2_group | phosphoELM; RegPhos |
S261 | GEDTLsDSDDE | CK2a1 | RegPhos |
S261 | GEDTLsDSDDE | CK2a2 | RegPhos |
S7 | MPGM | phosphoELM | |
S64 | PPLSPsRGFAE | Myc_N | PhosphoSitePlus |
T6 | TMPG | phosphoELM | |
S3 | STST | phosphoELM | |
S263 | DTLSDsDDEDD | CK2a2 | RegPhos |
S263 | DTLSDsDDEDD | CK2a1 | RegPhos |
S261 | GEDTLsDSDDE | CK2a1(CK2 alpha | RegPhos |
T8 | SCSTStMPGMI | phosphoELM | |
S263 | DTLSDsDDEDD | CK2_alpha | phosphoELM |
Dephosphorylation site |
MYCN_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000281043 | P358L | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000281043 | P74L | COSMIC | Melanoma | |
ENSP00000281043 | P358L | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000281043 | L402F | Ding2008, COSMIC | Lung Cancer | 18948947 |
ENSP00000281043 | P345T | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000281043 | P44L | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000281043 | P44L | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
Differential expressed protein |
MYCN_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
MYCN_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
CSK22_HUMAN | MYCN_HUMAN | kinase -> substrate | HPRD |
CSK21_HUMAN | MYCN_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
ZAGL2_HUMAN | MYCN_HUMAN | kinase -> substrate | RegPhos |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa05202 | Transcriptional misregulation in cancer |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0000785 | chromatin | TAS | cellular_component |
GO:2000378 | negative regulation of reactive oxygen species met | IEA | biological_process |
GO:0046983 | protein dimerization activity | IEA | molecular_function |
GO:0042733 | embryonic digit morphogenesis | IEA | biological_process |
GO:0048754 | branching morphogenesis of a tube | IEA | biological_process |
GO:0048712 | negative regulation of astrocyte differentiation | IEA | biological_process |
GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
GO:0010942 | positive regulation of cell death | IEA | biological_process |
GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
GO:0005634 | nucleus | IDA | cellular_component |
GO:0001502 | cartilage condensation | IEA | biological_process |
GO:0030324 | lung development | IEA | biological_process |
GO:0002053 | positive regulation of mesenchymal cell proliferat | IEA | biological_process |
GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
GO:0048704 | embryonic skeletal system morphogenesis | IEA | biological_process |
GO:0003677 | DNA binding | TAS | molecular_function |
GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
GO:0005515 | protein binding | IPI | molecular_function |