Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERCC3_HUMAN
Description:excision repair cross-complementing rodent repair deficiency, complementation group 3 [Source:HGNC Symbol;Acc:3435]
Location:chr2 q14.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S370GNSAVsVEQWKHPRD; phosphoELM; RegPhos; SysPTM
S751TMSSMsGADDTCK2a1(CK2 alphaRegPhos
Y581NKPYIyGPTSQHelicase_CPhosphoSitePlus
Y139SDITEyLRKLSHelicase_C_3PhosphoSitePlus
Y319AVLRPyQEKSLResIIIPhosphoSitePlus
S751TMSSMsGADDTCK2_alphaphosphoELM
S404KPIGCsVAISTResIIIPhosphoSitePlus
T232SGGPStSRVTDPET122PhosphoSitePlus
T236STSRVtDPQGKPET122PhosphoSitePlus
Y19SRKRHyEDEEDPhosphoSitePlus
S323PYQEKsLRKMFResIIIPhosphoSitePlus
Y758ADDTVyMEYHSPhosphoSitePlus
S751TMSSMsGADDTPhosphoSitePlus; HPRD; RegPhos
S242DPQGKsDIPMDPET122PhosphoSitePlus

Dephosphorylation site
ERCC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000285398G204RCOSMICLung Cancer20668451
ENSP00000285398A694TCOSMICOvarian Cancer20668451
ENSP00000285398Q190HCOSMICBreast Cancer20668451
ENSP00000285398K418QSjoblom2006, COSMIC, HPIBreast Cancer10447254, 16959974, 10447254, 16959974, 10447254 16959974
ENSP00000285398E517ACOSMICRenal Cancer20054297
ENSP00000285398R530*BIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000285398Prostate CancerMetastasistissueDown0.3218553995

Hyperphosphorylation site
ERCC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANERCC3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANERCC3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03420Nucleotide excision repair
hsa03022Basal transcription factors

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0000717nucleotide-excision repair, DNA duplex unwindingIMPbiological_process
GO:0000441SSL2-core TFIIH complexIEAcellular_component
GO:0009411response to UVIMPbiological_process
GO:0004386helicase activityIEAmolecular_function
GO:0042277peptide bindingIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0016887ATPase activityIDAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004003ATP-dependent DNA helicase activityIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0006289nucleotide-excision repairIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0005675holo TFIIH complexTAScellular_component
GO:0006361transcription initiation from RNA polymerase I proTASbiological_process
GO:0000439core TFIIH complexIEAcellular_component
GO:0008353RNA polymerase II carboxy-terminal domain kinase aIDAmolecular_function
GO:0033683nucleotide-excision repair, DNA incisionIMPbiological_process
GO:0005634nucleusTAScellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0008094DNA-dependent ATPase activityIMPmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0008134transcription factor bindingIDAmolecular_function
GO:0003684damaged DNA bindingNASmolecular_function
GO:0006366transcription from RNA polymerase II promoterIMPbiological_process
GO:0006200ATP catabolic processIEAbiological_process
GO:0006265DNA topological changeIMPbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0006363termination of RNA polymerase I transcriptionTASbiological_process
GO:0008104protein localizationIMPbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0032564dATP bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0000075cell cycle checkpointIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0006283transcription-coupled nucleotide-excision repairIDAbiological_process
GO:0009650UV protectionIEAbiological_process
GO:0006979response to oxidative stressIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0035315hair cell differentiationIMPbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:00431383'-5' DNA helicase activityIDAmolecular_function
GO:0006362transcription elongation from RNA polymerase I proTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0006281DNA repairIMPbiological_process
GO:0005654nucleoplasmTAScellular_component


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