Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VDR_HUMAN
Description:vitamin D (1,25- dihydroxyvitamin D3) receptor [Source:HGNC Symbol;Acc:12679]
Location:chr12 q13.11
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T175PNSRHtPSFSGPhosphoSitePlus
S182SFSGDsSSSCSPhosphoSitePlus
S172PSRPNsRHTPSPhosphoSitePlus
S208SNLDLsEEDSDCSNK2A1HPRD
Y380GSHLLyAKMIQHormone_recepPhosphoSitePlus
S51GFFRRsMKRKAzf-C4PhosphoSitePlus
S182SFSGDsSSSCSPKA_groupphosphoELM; RegPhos
S208SNLDLsEEDSDCK2a1(CK2 alphaRegPhos
S208SNLDLsEEDSDHormone_recepPhosphoSitePlus
S208SNLDLsEEDSDCK2_alphaphosphoELM
S208SNLDLsEEDSDCK2a1RegPhos
S208SNLDLsEEDSDCK2_groupphosphoELM; RegPhos
S208SNLDLsEEDSDCK2a1-rsRegPhos
Y293CGNQDyKYRVSHormone_recepPhosphoSitePlus

Dephosphorylation site
VDR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000229022G162CCOSMICSkin Cancer21984974
ENSP00000449573E353VCOSMICMelanoma21499247
ENSP00000378734G162CCOSMICSkin Cancer21984974
ENSP00000449573D149YCOSMICOvarian Cancer21720365
ENSP00000229022E353VCOSMICMelanoma21499247
ENSP00000449573L379FCOSMICCentral Nervous System Neoplasms18772396
ENSP00000229022L379FCOSMICCentral Nervous System Neoplasms18772396
ENSP00000378734D149YCOSMICOvarian Cancer21720365
ENSP00000378734E353VCOSMICMelanoma21499247
ENSP00000449573G162CCOSMICSkin Cancer21984974
ENSP00000229022D149YCOSMICOvarian Cancer21720365
ENSP00000378734L379FCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
VDR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VDR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANVDR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
LCK_HUMANVDR_HUMANkinase -> substrateRobert H Newman (2013)
VDR_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
VDR_HUMANCABP1_HUMANTF -> target geneTRANSFAC
VDR_HUMANOSTCN_HUMANTF -> target geneTRANSFAC
VDR_HUMANSOMA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04978Mineral absorption
hsa05152Tuberculosis
hsa04961Endocrine and other factor-regulated calcium reabs

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0070561vitamin D receptor signaling pathwayIDAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0000902cell morphogenesisIMPbiological_process
GO:0007595lactationIEAbiological_process
GO:0045618positive regulation of keratinocyte differentiatioIMPbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0046697decidualizationIEPbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0010980positive regulation of vitamin D 24-hydroxylase acIDAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010839negative regulation of keratinocyte proliferationIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0060745mammary gland branching involved in pregnancyIEAbiological_process
GO:0008434vitamin D3 receptor activityIEAmolecular_function
GO:0070644vitamin D response element bindingIDAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0046965retinoid X receptor bindingIPImolecular_function
GO:0060058positive regulation of apoptotic process involved IEAbiological_process
GO:0050892intestinal absorptionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060558regulation of calcidiol 1-monooxygenase activityIEAbiological_process


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