| UniProt/SwissProt ID: | VDR_HUMAN |
| Description: | vitamin D (1,25- dihydroxyvitamin D3) receptor [Source:HGNC Symbol;Acc:12679] |
| Location: | chr12 q13.11 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T175 | PNSRHtPSFSG | PhosphoSitePlus | |
| S182 | SFSGDsSSSCS | PhosphoSitePlus | |
| S172 | PSRPNsRHTPS | PhosphoSitePlus | |
| S208 | SNLDLsEEDSD | CSNK2A1 | HPRD |
| Y380 | GSHLLyAKMIQ | Hormone_recep | PhosphoSitePlus |
| S51 | GFFRRsMKRKA | zf-C4 | PhosphoSitePlus |
| S182 | SFSGDsSSSCS | PKA_group | phosphoELM; RegPhos |
| S208 | SNLDLsEEDSD | CK2a1(CK2 alpha | RegPhos |
| S208 | SNLDLsEEDSD | Hormone_recep | PhosphoSitePlus |
| S208 | SNLDLsEEDSD | CK2_alpha | phosphoELM |
| S208 | SNLDLsEEDSD | CK2a1 | RegPhos |
| S208 | SNLDLsEEDSD | CK2_group | phosphoELM; RegPhos |
| S208 | SNLDLsEEDSD | CK2a1-rs | RegPhos |
| Y293 | CGNQDyKYRVS | Hormone_recep | PhosphoSitePlus |
| Dephosphorylation site |
| VDR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000229022 | G162C | COSMIC | Skin Cancer | 21984974 | ENSP00000449573 | E353V | COSMIC | Melanoma | 21499247 | ENSP00000378734 | G162C | COSMIC | Skin Cancer | 21984974 | ENSP00000449573 | D149Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000229022 | E353V | COSMIC | Melanoma | 21499247 | ENSP00000449573 | L379F | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000229022 | L379F | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000378734 | D149Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378734 | E353V | COSMIC | Melanoma | 21499247 | ENSP00000449573 | G162C | COSMIC | Skin Cancer | 21984974 | ENSP00000229022 | D149Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378734 | L379F | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| VDR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| VDR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | VDR_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| LCK_HUMAN | VDR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VDR_HUMAN | CDN1A_HUMAN | TF -> target gene | TRANSFAC |
| VDR_HUMAN | CABP1_HUMAN | TF -> target gene | TRANSFAC |
| VDR_HUMAN | OSTCN_HUMAN | TF -> target gene | TRANSFAC |
| VDR_HUMAN | SOMA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04978 | Mineral absorption |
| hsa05152 | Tuberculosis |
| hsa04961 | Endocrine and other factor-regulated calcium reabs |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045944 | positive regulation of transcription from RNA poly | IMP | biological_process |
| GO:0070561 | vitamin D receptor signaling pathway | IDA | biological_process |
| GO:0001501 | skeletal system development | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0003707 | steroid hormone receptor activity | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0004879 | ligand-activated sequence-specific DNA binding RNA | IEA | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | IDA | biological_process |
| GO:0000902 | cell morphogenesis | IMP | biological_process |
| GO:0007595 | lactation | IEA | biological_process |
| GO:0045618 | positive regulation of keratinocyte differentiatio | IMP | biological_process |
| GO:0009887 | organ morphogenesis | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0046697 | decidualization | IEP | biological_process |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0010980 | positive regulation of vitamin D 24-hydroxylase ac | IDA | biological_process |
| GO:0010628 | positive regulation of gene expression | IMP | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0043401 | steroid hormone mediated signaling pathway | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010839 | negative regulation of keratinocyte proliferation | IMP | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0060745 | mammary gland branching involved in pregnancy | IEA | biological_process |
| GO:0008434 | vitamin D3 receptor activity | IEA | molecular_function |
| GO:0070644 | vitamin D response element binding | IDA | molecular_function |
| GO:0006874 | cellular calcium ion homeostasis | IEA | biological_process |
| GO:0046965 | retinoid X receptor binding | IPI | molecular_function |
| GO:0060058 | positive regulation of apoptotic process involved | IEA | biological_process |
| GO:0050892 | intestinal absorption | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0060558 | regulation of calcidiol 1-monooxygenase activity | IEA | biological_process |