Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EI2BE_HUMAN
Description:eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa [Source:HGNC Symbol;Acc:3261]
Location:chr3 q27.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S718AEEESsEphosphoELM
S717EAEEEsSEDDCK2a1-rsRegPhos
S717EAEEEsSEDDCK2a1RegPhos
S717EAEEEsSEDDCK2a2RegPhos
T182NVSVMtMIFKENTP_transferasePhosphoSitePlus
S466DDGEFsDDSGACK1aRegPhos
S27AGPGGsGGGGAPhosphoSitePlus
S20RANKRsGAGPGPhosphoSitePlus
S527EEESEsESEQSPhosphoSitePlus; HPRD; RegPhos
S535EQSMDsEEPDSPhosphoSitePlus; RegPhos
S718AEEESsEDDRegPhos
S535EQSMDsEEPDSGSK3BHPRD; RegPhos
S540SEEPDsRGGSPPhosphoSitePlus; RegPhos
S469EFSDDsGADQEPhosphoSitePlus; phosphoELM; RegPhos
S469EFSDDsGADQECSNK1A1HPRD
S717EAEEEsSEDDRegPhos
S717EAEEEsSEphosphoELM
S51VLVADsFDRRFCK1aRegPhos
S717EAEEEsSECSNK2A2HPRD
S717EAEEEsSECSNK2A1HPRD
S525NMEEEsESESEPhosphoSitePlus; HPRD; RegPhos
S718AEEESsEDDCK2a1RegPhos
S717EAEEEsSEDD_W2PhosphoSitePlus
S466DDGEFsDDSGAPhosphoSitePlus; phosphoELM; RegPhos
S544DSRGGsPQMDDGSK3BHPRD; RegPhos
S544DSRGGsPQMDDGSK3AHPRD; RegPhos
S535EQSMDsEEPDSGSK-3_groupphosphoELM
S718AEEESsEDDCK2a2RegPhos
S532SESEQsMDSEEPhosphoSitePlus; HPRD; RegPhos
S610LQQMDsPLDSSPhosphoSitePlus
S51VLVADsFDRRFCSNK1A1HPRD
S718AEEESsECSNK2A1HPRD
S718AEEESsECSNK2A2HPRD
S544DSRGGsPQMDDPhosphoSitePlus; phosphoELM; RegPhos
S718AEEESsEDD__W2PhosphoSitePlus
S718AEEESsEDDCK2a1-rsRegPhos
S469EFSDDsGADQECK1aRegPhos
S466DDGEFsDDSGACSNK1A1HPRD
Y319IRRWVyPLTPEPhosphoSitePlus
S540SEEPDsRGGSPGSK3AHPRD; RegPhos
S540SEEPDsRGGSPGSK3BHPRD; RegPhos
S535EQSMDsEEPDSGSK_groupRegPhos
S529ESESEsEQSMDPhosphoSitePlus; HPRD; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S540MDSEEPDsRGGSPQMHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000273783G516ECOSMICOvarian Cancer21720365
ENSP00000273783S529STCGAOvarian Cancer21720365, 18772890
ENSP00000273783Q512*COSMICOvarian Cancer21720365
ENSP00000273783R638CCOSMICOvarian Cancer21720365
ENSP00000273783S529TCOSMICOvarian Cancer21720365
ENSP00000273783Q512*TCGAOvarian Cancer21720365, 18772890
ENSP00000273783R638CTCGAOvarian Cancer21720365, 18772890
ENSP00000273783G516ETCGAOvarian Cancer21720365, 18772890
ENSP00000273783N263DTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
EI2BE_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EI2BE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK2_HUMANEI2BE_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANEI2BE_HUMANkinase -> substrateHPRD
KPCA_HUMANEI2BE_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANEI2BE_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANEI2BE_HUMANkinase -> substrateRegPhos
CSK21_HUMANEI2BE_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
GSK3B_HUMANEI2BE_HUMANkinase -> substrateRegPhos
KC1A_HUMANEI2BE_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045948positive regulation of translational initiationISSbiological_process
GO:0032057negative regulation of translational initiation inIEAbiological_process
GO:0014002astrocyte developmentIMPbiological_process
GO:0014003oligodendrocyte developmentIMPbiological_process
GO:0001541ovarian follicle developmentIMPbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0006412translationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0031369translation initiation factor bindingIEAmolecular_function
GO:0003743translation initiation factor activityIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0009408response to heatISSbiological_process
GO:0051716cellular response to stimulusIDAbiological_process
GO:0016070RNA metabolic processIEAbiological_process
GO:0006413translational initiationIDAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0016740transferase activityIEAmolecular_function
GO:0005085guanyl-nucleotide exchange factor activityISSmolecular_function
GO:0048708astrocyte differentiationIMPbiological_process
GO:0005851eukaryotic translation initiation factor 2B compleIDAcellular_component
GO:0042552myelinationIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005488bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0006950response to stressIMPbiological_process


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