| UniProt/SwissProt ID: | CDC37_HUMAN |
| Description: | cell division cycle 37 [Source:HGNC Symbol;Acc:1735] |
| Location: | chr19 p13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S13 | DHIEVsDDEDE | CK2a1 | RegPhos |
| Y298 | DPVEVyESLPE | CDC37_C | PhosphoSitePlus |
| S300 | VEVYEsLPEEL | CDC37_C | PhosphoSitePlus |
| S13 | DHIEVsDDEDE | CK2_group | phosphoELM; RegPhos |
| S377 | DEKDVsV____ | CDC37_C | PhosphoSitePlus; SysPTM |
| S13 | DHIEVsDDEDE | CSNK2A1 | HPRD |
| S13 | DHIEVsDDEDE | CSNK2A2 | HPRD |
| S5 | _MVDYsVWDHI | CDC37_N | PhosphoSitePlus |
| S13 | DHIEVsDDEDE | CK2a1-rs | RegPhos |
| S377 | DEKDV | HPRD; phosphoELM; SysPTM | |
| S13 | DHIEVsDDEDE | CK2a2 | RegPhos |
| S13 | DHIEVsDDEDE | CK2a1(CK2 alpha | RegPhos |
| S120 | NVDTLsKDGFS | CDC37_N; CDC37_M | PhosphoSitePlus |
| S13 | DHIEVsDDEDE | HPRD; RegPhos | |
| S13 | DHIEVsDDEDE | CK2_alpha | phosphoELM |
| T370 | EAVPKtGDEKD | CDC37_C | PhosphoSitePlus |
| S13 | DHIEVsDDEDE | CDC37_N | PhosphoSitePlus |
| Y278 | KAMKEyEEEER | CDC37_M | PhosphoSitePlus |
| Y298 | DPVEVyESLPE | HPRD; phosphoELM; RegPhos | |
| Dephosphorylation site |
| CDC37_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000222005 | P21L | COSMIC | Skin Cancer | 21984974 | ENSP00000222005 | R39C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000222005 | Uterine Cancer | Normal vs. Cancer | cell line | Up | 2.4 | 15838902 |
| Hyperphosphorylation site |
| CDC37_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | CDC37_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | CDC37_HUMAN | kinase -> substrate | RegPhos |
| CSK22_HUMAN | CDC37_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CDC37_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051082 | unfolded protein binding | TAS | molecular_function |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | TAS | biological_process |
| GO:0031435 | mitogen-activated protein kinase kinase kinase bin | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0060338 | regulation of type I interferon-mediated signaling | IMP | biological_process |
| GO:0006605 | protein targeting | TAS | biological_process |
| GO:0043422 | protein kinase B binding | IEA | molecular_function |
| GO:0060334 | regulation of interferon-gamma-mediated signaling | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051087 | chaperone binding | IEA | molecular_function |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0031072 | heat shock protein binding | IPI | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0051879 | Hsp90 protein binding | IEA | molecular_function |
| GO:0032587 | ruffle membrane | IEA | cellular_component |