Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGR_HUMAN
Description:Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog [Source:HGNC Symbol;Acc:3697]
Location:chr1 p36.11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y86LFIALyDYEARSH3_1PhosphoSitePlus
S173FLIREsETTKGSH2PhosphoSitePlus
Y412IKDDEyNPCQGPkinase_TyrPhosphoSitePlus
Y34GAADHyGPDPTPhosphoSitePlus; HPRD; phosphoELM
S181TKGAYsLSIRDSH2PhosphoSitePlus
Y412IKDDEyNPCQGFGRHPRD; RegPhos
Y28GDFRSyGAADHPhosphoSitePlus; HPRD; phosphoELM
Y180TTKGAySLSIRSH2PhosphoSitePlus
Y523SAEPQyQPGDQCSKRegPhos
Y412IKDDEyNPCQGautocatalysis RegPhos
Y523SAEPQyQPGDCSKHPRD
Y523SAEPQyQPGDQCskRegPhos
Y523SAEPQyQPGDQPhosphoSitePlus
Y523SAEPQyQPGDCskphosphoELM
Y209DMGGYyITTRVSH2PhosphoSitePlus
Y412IKDDEyNPCQGHPRD; phosphoELM
Y208LDMGGyYITTRHPRD; phosphoELM
Y208LDMGGyYITTRSH2PhosphoSitePlus
T453LTELItKGRIPPkinase_TyrPhosphoSitePlus
T211GGYYItTRVQFSH2PhosphoSitePlus
T212GYYITtRVQFNSH2PhosphoSitePlus
S183GAYSLsIRDWDSH2PhosphoSitePlus
T176RESETtKGAYSSH2PhosphoSitePlus
Y412IKDDEyNPCQGFgrphosphoELM; RegPhos

Dephosphorylation site
FGR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363117R171WBIOMARTBreast Cancer21930507, 21930502
ENSP00000363116R171WBIOMARTBreast Cancer21930507, 21930502
ENSP00000382126R171WBIOMARTBreast Cancer21930507, 21930502
ENSP00000363115R171WBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000382126Uterine CancerNormal vs. Cancercell lineUp1115838902

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y208SH2RKLDMGGyYITTRVQcholangiocellular carcinoma21253578PhosphoSitePlus
Y412Pkinase_TyrRLIKDDEyNPCQGSKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FGR_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANRXRG_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANENOA_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
FGR_HUMANRPAC1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANFGR_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FGR_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
MK15_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANANXA1_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCSK21_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNCOA2_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSRC_HUMANkinase -> substrateHPRD; RegPhos
PXK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANRBBP5_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANQKI_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANFGR_HUMANkinase -> substrateHPRD; RegPhos
FAK1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANHCLS1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CDK7_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
ST38L_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
MATK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045859regulation of protein kinase activityIEAbiological_process
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0005856cytoskeletonIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034988Fc-gamma receptor I complex bindingIDAmolecular_function
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0015629actin cytoskeletonIEAcellular_component
GO:0050764regulation of phagocytosisIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0032587ruffle membraneIEAcellular_component
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005886plasma membraneISScellular_component
GO:0005829cytosolIEAcellular_component
GO:0045087innate immune responseIEAbiological_process
GO:0034987immunoglobulin receptor bindingIEAmolecular_function
GO:0005758mitochondrial intermembrane spaceIEAcellular_component
GO:0043552positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0043306positive regulation of mast cell degranulationIEAbiological_process
GO:0002768immune response-regulating cell surface receptor sTASbiological_process
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:0045088regulation of innate immune responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008360regulation of cell shapeIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0009615response to virusTASbiological_process


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