Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:XRCC1_HUMAN
Description:X-ray repair complementing defective repair in Chinese hamster cells 1 [Source:HGNC Symbol;Acc:12828]
Location:chr19 q13.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S184DESANsLRPGAPhosphoSitePlus
T519PYAGStDENTDCK2a2RegPhos
T519PYAGStDENTDPhosphoSitePlus
S475IEGVQsEGQDNPhosphoSitePlus
S421SHSGGsGDEAPPhosphoSitePlus; phosphoELM; RegPhos
S518DPYAGsTDENTCK2_alphaphosphoELM
T279KLPAPtRTPATphosphoELM
S447AAGPSsPQKPPPhosphoSitePlus; phosphoELM; RegPhos
T198SRINKtSPVTAPhosphoSitePlus; phosphoELM
T523STDENtDSEEHPhosphoSitePlus
T519PYAGStDENTDCK2a1RegPhos
T519PYAGStDENTDCK2a1(CK2 alphaRegPhos
S485NGAEDsGDTEDCK2a1-rsRegPhos
S416EEDEAsHSGGSPhosphoSitePlus; phosphoELM; RegPhos
S236AIGSTsKPQESPhosphoSitePlus
S259EKKTPsKPPAQPhosphoSitePlus; phosphoELM
Y627LPHQLyGVVPQPhosphoSitePlus
S485NGAEDsGDTEDPhosphoSitePlus
S409AGPGSsSEEDEPhosphoSitePlus; phosphoELM; RegPhos
S268AQLSPsVPKRPPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S475IEGVQsEGQDNCK2a1-rsRegPhos
T457PTPEEtKAASPPhosphoSitePlus
S418DEASHsGGSGDPhosphoSitePlus; phosphoELM; RegPhos
S210DPAGPsYAAATPhosphoSitePlus
T488EDSGDtEDELRCK2_alphaphosphoELM
T453PQKPPtPEETKPhosphoSitePlus; phosphoELM; RegPhos
S525DENTDsEEHQECK2a1(CK2 alphaRegPhos
S525DENTDsEEHQEPhosphoSitePlus
T488EDSGDtEDELRPhosphoSitePlus
S199RINKTsPVTASPhosphoSitePlus
T488EDSGDtEDELRCK2a1(CK2 alphaRegPhos
S485NGAEDsGDTEDCK2_alphaphosphoELM
S485NGAEDsGDTEDCK2a1(CK2 alphaRegPhos
T202KTSPVtASDPAPhosphoSitePlus; phosphoELM
T523STDENtDSEEHCK2_alphaphosphoELM
T284TRTPAtAPVPAPhosphoSitePlus
T523STDENtDSEEHCK2a1(CK2 alphaRegPhos
S485NGAEDsGDTEDCK2a1RegPhos
T519PYAGStDENTDCK2a1-rsRegPhos
T257QEEKKtPSKPPPhosphoSitePlus; phosphoELM
S518DPYAGsTDENTPhosphoSitePlus
Y370ANTPKySQVLGBRCTPhosphoSitePlus
T519PYAGStDENTDCK2_alphaphosphoELM
S224SSAASsASPVSphosphoELM
Y211PAGPSyAAATLPhosphoSitePlus
S371NTPKYsQVLGLBRCTPhosphoSitePlus
S266PPAQLsPSVPKPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T235RAIGStSKPQEPhosphoSitePlus
S461ETKAAsPVLQEPhosphoSitePlus
S241SKPQEsPKGKRPhosphoSitePlus; phosphoELM; SysPTM
S518DPYAGsTDENTCK2a1(CK2 alphaRegPhos
S408MAGPGsSSEEDPhosphoSitePlus; phosphoELM; RegPhos
S226AASSAsPVSRAPhosphoSitePlus; phosphoELM
S461ETKAAsPVLQECK2a1RegPhos
S475IEGVQsEGQDNCK2_alphaphosphoELM
S518DPYAGsTDENTCK2a2RegPhos
T523STDENtDSEEHCK2a2RegPhos
S446QAAGPsSPQKPPhosphoSitePlus; phosphoELM
S475IEGVQsEGQDNCK2a1(CK2 alphaRegPhos
T440TKTKPtQAAGPPhosphoSitePlus
S204SPVTAsDPAGPPhosphoSitePlus
S410GPGSSsEEDEAPhosphoSitePlus; phosphoELM; RegPhos
S229SASPVsRAIGSPhosphoSitePlus; phosphoELM
S371NTPKYsQVLGLDNAPKRegPhos
S475IEGVQsEGQDNCK2a1RegPhos
S140PYSKDsPFGLSXRCC1_NPhosphoSitePlus
S461ETKAAsPVLQECK2a1-rsRegPhos
S525DENTDsEEHQECK2_alphaphosphoELM

Dephosphorylation site
XRCC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262887A35PCOSMICProstate Cancer20668451
ENSP00000262887R350WSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000262887R350WHPIColorectal Cancer16959974
ENSP00000262887R107HCOSMICHead and Neck Cancer21798893
ENSP00000262887M403VCOSMICLung Cancer20668451
ENSP00000262887P462SCOSMICBreast Cancer20668451
ENSP00000262887N183IDing2008, COSMICLung Cancer18948947
ENSP00000262887R246TCOSMICOvarian Cancer21720365

Differential expressed protein
XRCC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
XRCC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
VRK1_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANXRCC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CDK7_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANXRCC1_HUMANkinase -> substrateRegPhos
ST17A_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
PLK3_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANXRCC1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03410Base excision repair

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmTAScellular_component
GO:0006281DNA repairTASbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0021766hippocampus developmentIEAbiological_process
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0006284base-excision repairTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0000012single strand break repairIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process