Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF16_HUMAN
Description:interferon, gamma-inducible protein 16 [Source:HGNC Symbol;Acc:5395]
Location:chr1 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S546PQMPPsTPSSSPhosphoSitePlus
T562KPRLKtEPEEVPhosphoSitePlus
S775ILNPDsSMETSPhosphoSitePlus; phosphoELM
S437PPTTPsSSFFTPhosphoSitePlus
T149VSEEQtQPPSPPhosphoSitePlus
T434PQMPPtTPSSSPhosphoSitePlus
S719ILNPDsSMETSHPRD
Y317SGNIVyGVFMLHINPhosphoSitePlus
T428ESHLRtPQMPPPhosphoSitePlus
T547QMPPStPSSSFPhosphoSitePlus
S132QKRKKsTKEKACK2a1(CK2 alphaRegPhos
S106EVDATsPAPSTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S110TSPAPsTSSTVPhosphoSitePlus
T435QMPPTtPSSSFPhosphoSitePlus
S132QKRKKsTKEKACSNK2A1HPRD
Y704RGEFTyYEIQDHINPhosphoSitePlus
T491QMPPStPSSSFPhosphoSitePlus
S536IGPAEsHPHTPPhosphoSitePlus
S132QKRKKsTKEKAPhosphoSitePlus
S95KGPALsRKRKKPhosphoSitePlus
S132QKRKKsTKEKACK2a1-rsRegPhos
S166TAMGRsPSPKTPhosphoSitePlus; HPRD; phosphoELM
T779DSSMEtSPDFFPhosphoSitePlus
S720LNPDSsMETSPHPRD
T123EGAEAtPGAQKPhosphoSitePlus
S670LIRSAsVTPKIHINPhosphoSitePlus
S132QKRKKsTKEKACK2a1RegPhos
S438PTTPSsSFFTKPhosphoSitePlus
S780SSMETsPDFFFPhosphoSitePlus
T232IMFHAtVATQTHINPhosphoSitePlus
T540ESHPHtPQMPPPhosphoSitePlus
S132QKRKKsTKEKACK2_alphaphosphoELM
S575EDSAQsDLKEVHINPhosphoSitePlus
S153QTQPPsPAGAGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S480IGPAEsHPHTPPhosphoSitePlus
T484ESHPHtPQMPPPhosphoSitePlus
S776LNPDSsMETSPPhosphoSitePlus
S168MGRSPsPKTSLPhosphoSitePlus; HPRD; phosphoELM
S132QKRKKsTKEKACK2_groupphosphoELM; RegPhos
S549PPSTPsSSFLTPhosphoSitePlus
S490PQMPPsTPSSSPhosphoSitePlus
T237TVATQtQFFHVHINPhosphoSitePlus
T161GAGMStAMGRSPhosphoSitePlus
Y20EVINDyHFRMVPYRINPhosphoSitePlus
T194AKCQVtPRRNVPhosphoSitePlus
S519EDSAQsDLKEVHPRD
S142AGPKGsKVSEEPhosphoSitePlus

Dephosphorylation site
IF16_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357114E479KCOSMICSkin Cancer21984974
ENSP00000357114*730YCOSMICLung Cancer18948947
ENSP00000357113*730YCOSMICLung Cancer18948947

Differential expressed protein
IF16_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IF16_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANIF16_HUMANkinase -> substrateRegPhos
CSK21_HUMANIF16_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
IF16_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030097hemopoiesisNASbiological_process
GO:0003690double-stranded DNA bindingIDAmolecular_function
GO:0072332intrinsic apoptotic signaling pathway by p53 classIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032731positive regulation of interleukin-1 beta productiIDAbiological_process
GO:0051607defense response to virusIMPbiological_process
GO:0045071negative regulation of viral genome replicationIDAbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0002218activation of innate immune responseIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0008134transcription factor bindingIDAmolecular_function
GO:0071479cellular response to ionizing radiationIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0043392negative regulation of DNA bindingIDAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0009615response to virusNASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0006914autophagyIEAbiological_process
GO:0097202activation of cysteine-type endopeptidase activityIMPbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0030224monocyte differentiationIDAbiological_process
GO:0008283cell proliferationNASbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0010506regulation of autophagyIEPbiological_process
GO:2000117negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0042771intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0045824negative regulation of innate immune responseIDAbiological_process
GO:0042149cellular response to glucose starvationIDAbiological_process
GO:0001819positive regulation of cytokine productionTASbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0030099myeloid cell differentiationNASbiological_process


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