| UniProt/SwissProt ID: | IF16_HUMAN |
| Description: | interferon, gamma-inducible protein 16 [Source:HGNC Symbol;Acc:5395] |
| Location: | chr1 q23.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S546 | PQMPPsTPSSS | PhosphoSitePlus | |
| T562 | KPRLKtEPEEV | PhosphoSitePlus | |
| S775 | ILNPDsSMETS | PhosphoSitePlus; phosphoELM | |
| S437 | PPTTPsSSFFT | PhosphoSitePlus | |
| T149 | VSEEQtQPPSP | PhosphoSitePlus | |
| T434 | PQMPPtTPSSS | PhosphoSitePlus | |
| S719 | ILNPDsSMETS | HPRD | |
| Y317 | SGNIVyGVFML | HIN | PhosphoSitePlus |
| T428 | ESHLRtPQMPP | PhosphoSitePlus | |
| T547 | QMPPStPSSSF | PhosphoSitePlus | |
| S132 | QKRKKsTKEKA | CK2a1(CK2 alpha | RegPhos |
| S106 | EVDATsPAPST | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S110 | TSPAPsTSSTV | PhosphoSitePlus | |
| T435 | QMPPTtPSSSF | PhosphoSitePlus | |
| S132 | QKRKKsTKEKA | CSNK2A1 | HPRD |
| Y704 | RGEFTyYEIQD | HIN | PhosphoSitePlus |
| T491 | QMPPStPSSSF | PhosphoSitePlus | |
| S536 | IGPAEsHPHTP | PhosphoSitePlus | |
| S132 | QKRKKsTKEKA | PhosphoSitePlus | |
| S95 | KGPALsRKRKK | PhosphoSitePlus | |
| S132 | QKRKKsTKEKA | CK2a1-rs | RegPhos |
| S166 | TAMGRsPSPKT | PhosphoSitePlus; HPRD; phosphoELM | |
| T779 | DSSMEtSPDFF | PhosphoSitePlus | |
| S720 | LNPDSsMETSP | HPRD | |
| T123 | EGAEAtPGAQK | PhosphoSitePlus | |
| S670 | LIRSAsVTPKI | HIN | PhosphoSitePlus |
| S132 | QKRKKsTKEKA | CK2a1 | RegPhos |
| S438 | PTTPSsSFFTK | PhosphoSitePlus | |
| S780 | SSMETsPDFFF | PhosphoSitePlus | |
| T232 | IMFHAtVATQT | HIN | PhosphoSitePlus |
| T540 | ESHPHtPQMPP | PhosphoSitePlus | |
| S132 | QKRKKsTKEKA | CK2_alpha | phosphoELM |
| S575 | EDSAQsDLKEV | HIN | PhosphoSitePlus |
| S153 | QTQPPsPAGAG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S480 | IGPAEsHPHTP | PhosphoSitePlus | |
| T484 | ESHPHtPQMPP | PhosphoSitePlus | |
| S776 | LNPDSsMETSP | PhosphoSitePlus | |
| S168 | MGRSPsPKTSL | PhosphoSitePlus; HPRD; phosphoELM | |
| S132 | QKRKKsTKEKA | CK2_group | phosphoELM; RegPhos |
| S549 | PPSTPsSSFLT | PhosphoSitePlus | |
| S490 | PQMPPsTPSSS | PhosphoSitePlus | |
| T237 | TVATQtQFFHV | HIN | PhosphoSitePlus |
| T161 | GAGMStAMGRS | PhosphoSitePlus | |
| Y20 | EVINDyHFRMV | PYRIN | PhosphoSitePlus |
| T194 | AKCQVtPRRNV | PhosphoSitePlus | |
| S519 | EDSAQsDLKEV | HPRD | |
| S142 | AGPKGsKVSEE | PhosphoSitePlus | |
| Dephosphorylation site |
| IF16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357114 | E479K | COSMIC | Skin Cancer | 21984974 | ENSP00000357114 | *730Y | COSMIC | Lung Cancer | 18948947 | ENSP00000357113 | *730Y | COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| IF16_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IF16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | IF16_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | IF16_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| IF16_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030097 | hemopoiesis | NAS | biological_process |
| GO:0003690 | double-stranded DNA binding | IDA | molecular_function |
| GO:0072332 | intrinsic apoptotic signaling pathway by p53 class | IMP | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032731 | positive regulation of interleukin-1 beta producti | IDA | biological_process |
| GO:0051607 | defense response to virus | IMP | biological_process |
| GO:0045071 | negative regulation of viral genome replication | IDA | biological_process |
| GO:0045087 | innate immune response | IEA | biological_process |
| GO:0002218 | activation of innate immune response | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0008134 | transcription factor binding | IDA | molecular_function |
| GO:0071479 | cellular response to ionizing radiation | IDA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0043392 | negative regulation of DNA binding | IDA | biological_process |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0009615 | response to virus | NAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0006914 | autophagy | IEA | biological_process |
| GO:0097202 | activation of cysteine-type endopeptidase activity | IMP | biological_process |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0030224 | monocyte differentiation | IDA | biological_process |
| GO:0008283 | cell proliferation | NAS | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0010506 | regulation of autophagy | IEP | biological_process |
| GO:2000117 | negative regulation of cysteine-type endopeptidase | IDA | biological_process |
| GO:0042771 | intrinsic apoptotic signaling pathway in response | IDA | biological_process |
| GO:0045824 | negative regulation of innate immune response | IDA | biological_process |
| GO:0042149 | cellular response to glucose starvation | IDA | biological_process |
| GO:0001819 | positive regulation of cytokine production | TAS | biological_process |
| GO:0016607 | nuclear speck | IDA | cellular_component |
| GO:0030099 | myeloid cell differentiation | NAS | biological_process |