Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HDAC3_HUMAN
Description:histone deacetylase 3 [Source:HGNC Symbol;Acc:4854]
Location:chr5 q31.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S424DNDKEsDVEIRegPhos; SysPTM
S424DNDKEsDVEI_PhosphoSitePlus; SysPTM
S424DNDKEsDVphosphoELM; SysPTM
Y404GPEENySRPEAPhosphoSitePlus; HPRD; SysPTM
S424DNDKEsDVEICK2a1-rsRegPhos; SysPTM
S424DNDKEsDVEICK2a1RegPhos; SysPTM
S405PEENYsRPEAPHPRD; SysPTM
Y331SEYFEyFAPDFPhosphoSitePlus
S424DNDKEsDVCSNK2A1HPRD; SysPTM

Dephosphorylation site
HDAC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302967R301LCOSMICHead and Neck Cancer21798893
ENSP00000302967G176RCOSMICOvarian Cancer21720365

Differential expressed protein
HDAC3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HDAC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TBK1_HUMANHDAC3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANHDAC3_HUMANkinase -> substrateRegPhos
CSK21_HUMANHDAC3_HUMANkinase -> substrateHPRD
BMX_HUMANHDAC3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANHDAC3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05034Alcoholism
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0097372NAD-dependent histone deacetylase activity (H3-K18IEAmolecular_function
GO:0051225spindle assemblyIMPbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0033558protein deacetylase activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0046970NAD-dependent histone deacetylase activity (H4-K16IEAmolecular_function
GO:0016568chromatin modificationTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003714transcription corepressor activityIMPmolecular_function
GO:0008134transcription factor bindingTASmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0000118histone deacetylase complexTAScellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0045786negative regulation of cell cycleTASbiological_process
GO:0006476protein deacetylationIDAbiological_process
GO:0016575histone deacetylationIEAbiological_process
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0046329negative regulation of JNK cascadeIMPbiological_process
GO:0032922circadian regulation of gene expressionIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005876spindle microtubuleIDAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 IEAmolecular_function
GO:0004407histone deacetylase activityTASmolecular_function
GO:0007219Notch signaling pathwayTASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0032041NAD-dependent histone deacetylase activity (H3-K14IEAmolecular_function
GO:0017053transcriptional repressor complexIDAcellular_component
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0007346regulation of mitotic cell cycleIEAbiological_process


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