Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TIF1A_HUMAN
Description:tripartite motif containing 24 [Source:HGNC Symbol;Acc:11812]
Location:chr7 q33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S153TTEVPsSTVEKPhosphoSitePlus
T776STSEEtVLRSDPhosphoSitePlus
S744IVKQEsDEESRPhosphoSitePlus
T818LHVGEtRKEDDPhosphoSitePlus; HPRD
S1028KFSDDsDDDFVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S985EFRNEsEDNKFHPRD
Y733GPPENyDFPVVPhosphoSitePlus
S762RSILTsLLLNSPhosphoSitePlus
Y936TVPDYyKIIKNBromodomainPhosphoSitePlus
S777DPSQKsPLHVGHPRD
S768LLLNSsQSSTSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T148FFVKDtTEVPSPhosphoSitePlus
S626NRTVQsPNSSVHPRD
T784LHVGEtRKEDDHPRD
S653PIRSPsASSVGHPRD
S667NSSVPsPGLAGPhosphoSitePlus; HPRD; phosphoELM
S991EDNKFsDDSDDHPRD
S773SQSSTsEETVLHPRD; phosphoELM
S734LLLNSsQSSTSHPRD
S748ESDEEsRPQNAPhosphoSitePlus
S739SQSSTsEETVLHPRD
S771NSSQSsTSEETPhosphoSitePlus; HPRD
S1008KKRLKsIEERQHPRD
S874FCRDLsKPEVEPhosphoSitePlus
T101LGSAEtPPPVPPhosphoSitePlus; HPRD
S1042KKRLKsIEERQPhosphoSitePlus; HPRD; SysPTM
S994KFSDDsDDDFVHPRD
S687PIRSPsASSVGPhosphoSitePlus; HPRD
S654QPRPPsNRTVQPhosphoSitePlus
Y916LLLFLyCHEMSBromodomainPhosphoSitePlus
S1019EFRNEsEDNKFPhosphoSitePlus; HPRD; phosphoELM
S808EWLDPsQKSPLPhosphoSitePlus; HPRD; phosphoELM
T772SSQSStSEETVPhosphoSitePlus; HPRD
S737NSSQSsTSEETHPRD
S651HPPIRsPSASSHPRD
Y234EQLKLyCETCDzf-B_boxPhosphoSitePlus
S660NRTVQsPNSSVPhosphoSitePlus; HPRD; phosphoELM
S774EWLDPsQKSPLHPRD
S110VPAPGsPVSGSPhosphoSitePlus; HPRD
S633NSSVPsPGLAGHPRD
S452PPSGLsSNQLSPhosphoSitePlus
S663VQSPNsSVPSPPhosphoSitePlus
S811DPSQKsPLHVGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1025EDNKFsDDSDDPhosphoSitePlus; HPRD; phosphoELM
S154TEVPSsTVEKSPhosphoSitePlus
S685HPPIRsPSASSPhosphoSitePlus; HPRD; phosphoELM
T738SSQSStSEETVHPRD
S664QSPNSsVPSPGPhosphoSitePlus

Dephosphorylation site
TIF1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000390829I270VCOSMICHead and Neck Cancer21798893
ENSP00000340507I270VCOSMICHead and Neck Cancer21798893
ENSP00000340507I320THPIOvarian Cancer17344846
ENSP00000390829F835LBIOMARTBreast Cancer21930507, 21930502
ENSP00000340507F869LBIOMARTBreast Cancer21930507, 21930502
ENSP00000390829*1017KCOSMICMelanoma21499247
ENSP00000390829R391HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000390829I320TCOSMICOvarian Cancer
ENSP00000340507E774QCOSMICHead and Neck Cancer21798893
ENSP00000340507R391HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000340507P533SCOSMICGastric Cancer21097718
ENSP00000390829P499SCOSMICGastric Cancer21097718
ENSP00000340507K1002NCOSMICOvarian Cancer21720365
ENSP00000340507D707HCOSMICOvarian Cancer20668451
ENSP00000340507F1010CCOSMICHead and Neck Cancer21798893
ENSP00000390829Q192*COSMICSkin Cancer21984974
ENSP00000340507T403NHPILung Cancer17344846
ENSP00000340507Q192*COSMICSkin Cancer21984974
ENSP00000390829K968NCOSMICOvarian Cancer21720365
ENSP00000390829D673HCOSMICOvarian Cancer20668451
ENSP00000340507R1009SCOSMICCentral Nervous System Neoplasms21163964
ENSP00000390829T403NCOSMICLung Cancer16140923
ENSP00000390829E740QCOSMICHead and Neck Cancer21798893
ENSP00000390829F976CCOSMICHead and Neck Cancer21798893
ENSP00000390829R975SCOSMICCentral Nervous System Neoplasms21163964

Differential expressed protein
TIF1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TIF1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TESK2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MOS_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TIF1A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0030163protein catabolic processIEAbiological_process
GO:0030163protein catabolic processIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0002039p53 bindingIEAmolecular_function
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0031647regulation of protein stabilityIEAbiological_process
GO:0034056estrogen response element bindingIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005719nuclear euchromatinIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008270zinc ion bindingIDAmolecular_function
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0042981regulation of apoptotic processIMPbiological_process
GO:0016922ligand-dependent nuclear receptor bindingIEAmolecular_function
GO:0070577histone acetyl-lysine bindingIDAmolecular_function
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0070562regulation of vitamin D receptor signaling pathwayIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0005726perichromatin fibrilsIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0016567protein ubiquitinationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005102receptor bindingTASmolecular_function
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0016567protein ubiquitinationIDAbiological_process
GO:0055074calcium ion homeostasisIEAbiological_process
GO:0071391cellular response to estrogen stimulusIDAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0031647regulation of protein stabilityIMPbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0002039p53 bindingIPImolecular_function


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