| UniProt/SwissProt ID: | JAM1_HUMAN |
| Description: | Junctional adhesion molecule A [Source:UniProtKB/Swiss-Prot;Acc:Q9Y624] |
| Location: | chr1 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y107 | EDTGTyTCMVS | V-set | PhosphoSitePlus |
| S287 | QPSARsEGEFK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S133 | VLVPPsKPTVN | Ig_2 | PhosphoSitePlus |
| S275 | KKGTSsKKVIY | HPRD; phosphoELM | |
| S141 | TVNIPsSATIG | HPRD | |
| T92 | VTFLPtGITFK | PRKCA | HPRD |
| T95 | LPTGItFKSVT | HPRD | |
| S284 | IYSQPsARSEG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T92 | VTFLPtGITFK | PKCa | RegPhos |
| T100 | TFKSVtREDTG | V-set | PhosphoSitePlus |
| S98 | GITFKsVTRED | V-set | PhosphoSitePlus |
| T136 | PPSKPtVNIPS | HPRD | |
| S34 | VTVHSsEPEVR | CK2a1 | RegPhos |
| S281 | KKVIYsQPSAR | PhosphoSitePlus; HPRD; phosphoELM | |
| S142 | VNIPSsATIGN | HPRD | |
| T70 | DQGDTtRLVCY | PKCa | RegPhos |
| Y280 | SKKVIySQPSA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S133 | VLVPPsKPTVN | HPRD | |
| S296 | FKQTSsF | HPRD | |
| T144 | IPSSAtIGNRA | HPRD | |
| T70 | DQGDTtRLVCY | PRKCA | HPRD |
| S34 | VTVHSsEPEVR | CK2a1-rs | RegPhos |
| S34 | VTVHSsEPEVR | CSNK2A1 | HPRD |
| T273 | RTKKGtSSKKV | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| JAM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357005 | D200H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000289779 | G120W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000337141 | D200H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000289779 | D200H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000289779 | L14F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| JAM1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y280 | TSSKKVIySQPSARS | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | JAM1_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | JAM1_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | JAM1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005911 | cell-cell junction | TAS | cellular_component |
| GO:0045216 | cell-cell junction organization | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0030054 | cell junction | TAS | cellular_component |
| GO:0030855 | epithelial cell differentiation | IEA | biological_process |
| GO:0005923 | tight junction | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0070830 | tight junction assembly | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0034329 | cell junction assembly | TAS | biological_process |