Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BCR_HUMAN
Description:breakpoint cluster region [Source:HGNC Symbol;Acc:1014]
Location:chr22 q11.23
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S467SSPHLsSKGRGPhosphoSitePlus; HPRD
T641KNSLEtLLYKPRhoGEFPhosphoSitePlus
Y246GVDGDyEDAELFESHPRD; RegPhos
T302LRSQStSEQEKPhosphoSitePlus
T898HSIPLtINKEDPhosphoSitePlus
S626NLRARsNKDAKRhoGEFPhosphoSitePlus
Y177AEKPFyVNVEFPhosphoSitePlus; phosphoELM; RegPhos
T310QEKRLtWPRRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y910ESPGLyGFLNVPhosphoSitePlus
T1018RDWQRtVIAMNPhosphoSitePlus
S267DANGGsRPPWPPhosphoSitePlus
T693INEEItPRRQSPhosphoSitePlus
S202SDRISsLGSQAPhosphoSitePlus
S894LQTVHsIPLTIPhosphoSitePlus
S303RSQSTsEQEKRPhosphoSitePlus
S351SSGQSsRVSPSPhosphoSitePlus
S462DDSPSsSPHLSPhosphoSitePlus
Y598AFVDNyGVAMEHPRD; phosphoELM; RegPhos
Y436GTPPGyGCAADPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y644LETLLyKPVDRHPRD; phosphoELM; RegPhos
T651PVDRVtRSTLVRhoGEFPhosphoSitePlus
S1220DSKRQsILFSTHPRD
S315TWPRRsYSPRSHPRD
S317PRRSYsPRSFEPhosphoSitePlus; HPRD
T432DGSFGtPPGYGPhosphoSitePlus
Y591SQLGVyRAFVDRhoGEFPhosphoSitePlus
S222HGAGSsVGDASPhosphoSitePlus
Y598AFVDNyGVAMERhoGEFPhosphoSitePlus
S236YRGRSsESSCGPhosphoSitePlus; RegPhos
S201VSDRIsSLGSQPhosphoSitePlus
S463DSPSSsPHLSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S540QPVLTsQQIETRhoGEFPhosphoSitePlus
Y58RFRMIyLQTLLBcr-Abl_Oligo; DUF827PhosphoSitePlus
Y283PYQSIyVGGMMFesphosphoELM; RegPhos
S429GDADGsFGTPPPhosphoSitePlus
Y279LEYQPyQSIYVPhosphoSitePlus
Y246GVDGDyEDAELPhosphoSitePlus; RegPhos
S340NENLTsSEEDFPhosphoSitePlus
S227SVGDAsRPPYRPhosphoSitePlus
S906KEDDEsPGLYGPhosphoSitePlus
Y177AEKPFyVNVEFABL1RegPhos
Y360PSPTTyRMFRDPhosphoSitePlus; HPRD; RegPhos
Y844RNGKSyTFLISPHPhosphoSitePlus
Y328DCGGGyTPDCSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S461IDDSPsSSPHLPhosphoSitePlus
S18AQFPDsEPPRMBcr-Abl_Oligo; DUF827PhosphoSitePlus
T410VGVRKtGQIWPPhosphoSitePlus
S1035SVKFNsREFSLPhosphoSitePlus
Y751GKTQQyDCKWYPHPhosphoSitePlus
Y276WPPLEyQPYQSFESHPRD; RegPhos
Y177AEKPFyVNVEFAblphosphoELM
S572RVQQWsHQQRVRhoGEFPhosphoSitePlus
Y276WPPLEyQPYQSFesphosphoELM; RegPhos
S281YQPYQsIYVGGPhosphoSitePlus
Y455QDGLPyIDDSPPhosphoSitePlus
S1039NSREFsLKRMPPhosphoSitePlus
S235PYRGRsSESSCPhosphoSitePlus
S299GPLLRsQSTSEPhosphoSitePlus
T635AKDPTtKNSLERhoGEFPhosphoSitePlus
S374SPSQNsQQSFDPhosphoSitePlus
T359SPSPTtYRMFRPhosphoSitePlus
Y513ASEETyLSHLERhoGEFPhosphoSitePlus
T845NGKSYtFLISSPHPhosphoSitePlus
Y1089EEVGIyRVSGVRhoGAPPhosphoSitePlus
Y644LETLLyKPVDRRhoGEFPhosphoSitePlus
Y756YDCKWyIPLTDPHPhosphoSitePlus
S1264DSKRQsILFSTCK2a1(CK2 alphaRegPhos
Y279LEYQPyQSIYVFESHPRD; RegPhos
S1264DSKRQsILFSTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S698TPRRQsMTVKKPhosphoSitePlus
S473SKGRGsRDALVPhosphoSitePlus
S354QSSRVsPSPTTPhosphoSitePlus; HPRD; RegPhos
Y360PSPTTyRMFRDABL1RegPhos
Y852LISSDyERAEWPHPhosphoSitePlus
Y591SQLGVyRAFVDHPRD; phosphoELM; RegPhos
S205ISSLGsQAMQMPhosphoSitePlus
Y177AEKPFyVNVEFFesphosphoELM; RegPhos
Y177AEKPFyVNVEFHCKHPRD; phosphoELM; RegPhos
T329CGGGYtPDCSSPhosphoSitePlus
S320SYSPRsFEDCGPhosphoSitePlus
Y177AEKPFyVNVEFFESHPRD; RegPhos
S1264DSKRQsILFSTCK2_alphaphosphoELM
Y276WPPLEyQPYQSPhosphoSitePlus
S301LLRSQsTSEQEPhosphoSitePlus
Y231ASRPPyRGRSSPhosphoSitePlus; phosphoELM; RegPhos
S843SRNGKsYTFLIPHPhosphoSitePlus
S239RSSESsCGVDGPhosphoSitePlus
S638PTTKNsLETLLRhoGEFPhosphoSitePlus
T634DAKDPtTKNSLRhoGEFPhosphoSitePlus
Y283PYQSIyVGGMMPhosphoSitePlus; HPRD; RegPhos
S1030IEVKLsVKFNSPhosphoSitePlus
Y360PSPTTyRMFRDAblphosphoELM
T130KARPGtARRPGPhosphoSitePlus
Y554KVPELyEIHKERhoGEFPhosphoSitePlus
T358VSPSPtTYRMFPhosphoSitePlus
S468SPHLSsKGRGSPhosphoSitePlus
T1049PSRKQtGVFGVPhosphoSitePlus
S653DRVTRsTLVLHRhoGEFPhosphoSitePlus
Y246GVDGDyEDAELFesphosphoELM; RegPhos
Y279LEYQPyQSIYVFesphosphoELM; RegPhos
S459PYIDDsPSSSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y561IHKEFyDGLFPRhoGEFPhosphoSitePlus
S919NVIVHsATGFKC2PhosphoSitePlus
S356SRVSPsPTTYRPhosphoSitePlus; HPRD
S122PDGEGsPGKARPhosphoSitePlus; HPRD; phosphoELM
S215MERKKsQHGAGPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y177ADAEKPFyVNVEFHHPTPN1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303507S400PGreenman2007Other Cancer(urinary_tract cancer)17344846, 18428421
ENSP00000303507S400PGreenman2007, HPIUrinary Bladder Cancer17344846, 18428421
ENSP00000303507D451NTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000303507A426ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000303507Y950FTCGAOvarian Cancer21720365, 18772890
ENSP00000303507A138TTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
BCR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y177ADAEKPFyVNVEFHHchronic myelogenous leukemia12124177PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANBCR_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
BCR_HUMAN1433T_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANBCR_HUMANkinase -> substrateRegPhos
CSK21_HUMANBCR_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANBCR_HUMANkinase -> substrateRegPhos
FES_HUMANBCR_HUMANkinase -> substrateRegPhos
BCR_HUMANAFAD_HUMANkinase -> substrateHPRD; RegPhos
PTN1_HUMANBCR_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046777protein autophosphorylationIEAbiological_process
GO:0043314negative regulation of neutrophil degranulationIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030675Rac GTPase activator activityIEAmolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0019899enzyme bindingIEAmolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0032855positive regulation of Rac GTPase activityIEAbiological_process
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0016301kinase activityTASmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005096GTPase activator activityTASmolecular_function
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0051726regulation of cell cycleIEAbiological_process


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