Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTEN_HUMAN
Description:phosphatase and tensin homolog [Source:HGNC Symbol;Acc:9588]
Location:chr10 q23.31
Node attribute:PPI(target); PPI(source); Enzyme(target); Enzyme(source); phosphotase; substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T383RYSDTtDSDPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y315DNDKEyLVLTLLckphosphoELM; RegPhos
T232SNSGPtRREDKROCK1phosphoELM; RegPhos
S229IYSSNsGPTRRROCK1phosphoELM; RegPhos
S380DHYRYsDTTDSAKT1HPRD; RegPhos
T382YRYSDtTDSDPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y177RRYVYyYSYLLPhosphoSitePlus
S370VTPDVsDNEPDCK2a1-rsRegPhos
Y315DNDKEyLVLTLHPRD; RegPhos
S370VTPDVsDNEPDCK2a1RegPhos
S370VTPDVsDNEPDCK2a2RegPhos
T366SSTSVtPDVSDPhosphoSitePlus; phosphoELM; RegPhos
S380DHYRYsDTTDSCK2a1(CK2 alphaRegPhos
Y176QRRYVyYYSYLPhosphoSitePlus
Y336DKANRyFSPNFPTEN_C2PhosphoSitePlus
Y315DNDKEyLVLTLPTEN_C2PhosphoSitePlus
S380DHYRYsDTTDSCK2_alphaphosphoELM
T232SNSGPtRREDKPTEN_C2PhosphoSitePlus
S385SDTTDsDPENEAKT1HPRD; RegPhos
Y155EALDFyGEVRTDSPcPhosphoSitePlus
S227VKIYSsNSGPTPTEN_C2PhosphoSitePlus
T366SSTSVtPDVSDCK2_groupRegPhos
T366SSTSVtPDVSDCK2a1(CK2 alphaRegPhos
S385SDTTDsDPENELKB1RegPhos
Y240EDKFMyFEFPQHPRD; RegPhos
T382YRYSDtTDSDPCK2_alphaphosphoELM
Y178RYVYYySYLLKPhosphoSitePlus
S370VTPDVsDNEPDCK2_groupRegPhos
S385SDTTDsDPENESTK11HPRD
Y138VMICAyLLHRGDSPcPhosphoSitePlus
S380DHYRYsDTTDSPhosphoSitePlus; phosphoELM
S370VTPDVsDNEPDCK2a1(CK2 alphaRegPhos
S380DHYRYsDTTDSAKT_groupRegPhos
Y240EDKFMyFEFPQPTEN_C2PhosphoSitePlus
S370VTPDVsDNEPDCSNK2A1HPRD
S370VTPDVsDNEPDCSNK2A2HPRD
S385SDTTDsDPENECK2a1(CK2 alphaRegPhos
T401QHTQItKVRegPhos
T366SSTSVtPDVSDCK2a1RegPhos
T366SSTSVtPDVSDCK2a2RegPhos
Y68NHYKIyNLCAEDSPcPhosphoSitePlus
S370VTPDVsDNEPDCK2_alphaphosphoELM
S362PEASSsTSVTPPhosphoSitePlus
S385SDTTDsDPENEAKT_groupRegPhos
T366SSTSVtPDVSDGSK-3_betaphosphoELM
T366SSTSVtPDVSDGSK3B(GSK3 betaRegPhos
Y46RLEGVyRNNIDPhosphoSitePlus
S385SDTTDsDPENECK2_groupphosphoELM; RegPhos
S362PEASSsTSVTPGSK-3_betaphosphoELM
T366SSTSVtPDVSDCSNK2A1HPRD
Y180VYYYSyLLKNHPhosphoSitePlus
T366SSTSVtPDVSDCK2a1-rsRegPhos
S362PEASSsTSVTPGSK3B(GSK3 betaRegPhos
S385SDTTDsDPENECK2_alphaphosphoELM
T366SSTSVtPDVSDCSNK2A2HPRD
T382YRYSDtTDSDPLKB1phosphoELM
T401QHTQItKV___PhosphoSitePlus
Y240EDKFMyFEFPQLckphosphoELM; RegPhos
S385SDTTDsDPENEPhosphoSitePlus; phosphoELM
S370VTPDVsDNEPDPhosphoSitePlus; phosphoELM
S179YVYYYsYLLKNPhosphoSitePlus
T382YRYSDtTDSDPCK2a1(CK2 alphaRegPhos
S229IYSSNsGPTRRPTEN_C2PhosphoSitePlus
Y174PSQRRyVYYYSDSPcPhosphoSitePlus

Dephosphorylation site
PTEN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361021L146*COSMICUterine Cancer20062086
ENSP00000361021S364CCOSMICCentral Nervous System Neoplasms17151929
ENSP00000361021G132DCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021F37SCOSMICOther Cancer10955808
ENSP00000361021P213fs*4COSMICCentral Nervous System Neoplasms17151929
ENSP00000361021C136FCOSMICBrain Cancer11668501
ENSP00000361021T202ICOSMICBiliary Tract Cancer21087480
ENSP00000361021W111RDing2008Neoplasms by Histologic Type11939587, 18428421, 18948947
ENSP00000361021E256*COSMICUterine Cancer15069681
ENSP00000361021Q149*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021F243fs*13COSMICUterine Cancer10851265
ENSP00000361021T348ICOSMICProstate Cancer11234884
ENSP00000361021N82TCOSMICGastric Cancer12695913
ENSP00000361021N69fs*30COSMICUterine Cancer10657903
ENSP00000361021I5LCOSMICCentral Nervous System Neoplasms12168116
ENSP00000361021H75NCOSMICCentral Nervous System Neoplasms19644652
ENSP00000361021E91QCOSMICProstate Cancer9443392
ENSP00000361021F90fs*9COSMICUterine Cancer9307275
ENSP00000361021Y336*COSMICUterine Cancer9326929
ENSP00000361021E314*COSMICUterine Cancer11006040
ENSP00000361021R74ICOSMICIntestines Cancer16094359
ENSP00000361021I135MCOSMICUterine Cancer15069681
ENSP00000361021N31HCOSMICIntestines Cancer19962665
ENSP00000361021I168fs*15COSMICOvarian Cancer10629071
ENSP00000361021F154fs*5COSMICCentral Nervous System Neoplasms18772396
ENSP00000361021Y68CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021F154LCOSMICUterine Cancer15923161
ENSP00000361021L193PCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021L320*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021K164RCOSMICUterine Cancer20062086
ENSP00000361021R130*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021A151TCOSMICUterine Cancer11156411
ENSP00000361021K223fs*33COSMICUterine Cancer11190805
ENSP00000361021E235*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021G20*COSMICProstate Cancer11234884
ENSP00000361021R234WCOSMICOther Cancer10955808
ENSP00000361021N323KCOSMICIntestines Cancer14724591
ENSP00000361021Y174*COSMICSarcoma11854598
ENSP00000361021R173CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021R15SHPINeoplasms by Histologic Type9090379
ENSP00000361021R130QCOSMICUterine Cancer9354433
ENSP00000361021K147*COSMICSkin Cancer11291079
ENSP00000361021Y16*COSMICUterine Cancer18757403
ENSP00000361021F271STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021A137VCOSMICHead and Neck Cancer12370746
ENSP00000361021G165ECOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021L247*COSMICUterine Cancer15385114
ENSP00000361021L70PCOSMICUterine Cancer10657903
ENSP00000361021E299*COSMICUterine Cancer11849740
ENSP00000361021L42RHPINeoplasms by Histologic Type9090379
ENSP00000361021P339LCOSMICMelanoma11297763
ENSP00000361021L182*COSMICUterine Cancer21266528
ENSP00000361021V175LTCGAOvarian Cancer21720365, 18772890
ENSP00000361021P38SCOSMICMelanoma19234609
ENSP00000361021P95LCOSMICUterine Cancer9307275
ENSP00000361021C218*COSMICUterine Cancer9326929
ENSP00000361021L140FCOSMICUterine Cancer21266528
ENSP00000361021E314KCOSMICUterine Cancer11156411
ENSP00000361021L146fs*1COSMICUterine Cancer15385114
ENSP00000361021H93YCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021D331GCOSMICHead and Neck Cancer11801303
ENSP00000361021E288*COSMICOvarian Cancer11395387
ENSP00000361021K80ECOSMICCentral Nervous System Neoplasms10096247
ENSP00000361021V54LCOSMICUterine Cancer11156411
ENSP00000361021S229*COSMICCentral Nervous System Neoplasms14633303
ENSP00000361021F21fs*3COSMICUterine Cancer18757403
ENSP00000361021H397YCOSMICCentral Nervous System Neoplasms10068201
ENSP00000361021Y27NCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021P246LDing2008Skin Cancer10427138, 10560660, 15195137, 18428421, 18948947, 9393744
ENSP00000361021I33SCOSMICUterine Cancer9326929
ENSP00000361021T277ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021T26fs*28COSMICUterine Cancer11006040
ENSP00000361021A192fs*7COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021F241LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021Y225CCOSMICHead and Neck Cancer11801303
ENSP00000361021H141YCOSMICCentral Nervous System Neoplasms11355302
ENSP00000361021Y46HCOSMICUterine Cancer21984976
ENSP00000361021R233fs*23COSMICOvarian Cancer21720365
ENSP00000361021A121PHPINeoplasms by Histologic Type9331071 10866302 19471547
ENSP00000361021I67KCOSMICGastric Cancer12695913
ENSP00000361021P30fs*24COSMICUterine Cancer9865913
ENSP00000361021E352*COSMICRenal Cancer10628321
ENSP00000361021F257LCOSMICCentral Nervous System Neoplasms11273008
ENSP00000361021F241LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021D24YCOSMICOther Cancer11108659
ENSP00000361021G165*COSMICLung Cancer20018398
ENSP00000361021R14GCOSMICOther Cancer10955808
ENSP00000361021T202fs*19COSMICCentral Nervous System Neoplasms9090379
ENSP00000361021R308fs*9COSMICOvarian Cancer9605750
ENSP00000361021E288fs*3COSMICUterine Cancer11006040
ENSP00000361021T2ICOSMICSarcoma17646270
ENSP00000361021Q261*COSMICCentral Nervous System Neoplasms11556543
ENSP00000361021Q245*COSMICUterine Cancer9307275
ENSP00000361021V275ACOSMICUterine Cancer18757403
ENSP00000361021E256KCOSMICCentral Nervous System Neoplasms16410744
ENSP00000361021K254*COSMICUterine Cancer15069681
ENSP00000361021D326GCOSMICCentral Nervous System Neoplasms11438483
ENSP00000361021R130fs*4COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021S338TCOSMICUterine Cancer11555573
ENSP00000361021G132fs*2COSMICUterine Cancer10851265
ENSP00000361021R159fs*8COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021L318fs*3COSMICUterine Cancer10851265
ENSP00000361021G129*COSMICIntestines Cancer17088437
ENSP00000361021D268fs*8COSMICUterine Cancer10657903
ENSP00000361021T160ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021P374fs*30COSMICCentral Nervous System Neoplasms9393744
ENSP00000361021T167PHPIBreast Cancer9256433
ENSP00000361021Y188*COSMICUterine Cancer10851265
ENSP00000361021K13*COSMICUterine Cancer21266528
ENSP00000361021G132DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021F21SCOSMICUterine Cancer21266528
ENSP00000361021D19NCOSMICMelanoma10978354
ENSP00000361021Y138fs*9COSMICUterine Cancer20062086
ENSP00000361021Y16CCOSMICLymphoma9787181
ENSP00000361021R47GCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021T167STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021T398SCOSMICCentral Nervous System Neoplasms19963122
ENSP00000361021Y336FCOSMICCentral Nervous System Neoplasms14655763
ENSP00000361021M35VCOSMICCentral Nervous System Neoplasms11939587
ENSP00000361021P244fs*12COSMICProstate Cancer9671408
ENSP00000361021Y176*COSMICCentral Nervous System Neoplasms10416987
ENSP00000361021K342NCOSMICLymphoma9596690
ENSP00000361021T383ICOSMICSarcoma17646270
ENSP00000361021V133ICOSMICUterine Cancer9765621
ENSP00000361021A39TCOSMICCentral Nervous System Neoplasms12175345
ENSP00000361021C124SCOSMICCentral Nervous System Neoplasms10416987
ENSP00000361021D375NCOSMICCentral Nervous System Neoplasms12168116
ENSP00000361021R55GCOSMICProstate Cancer11234884
ENSP00000361021G156RCOSMICCentral Nervous System Neoplasms11123721
ENSP00000361021H123YHPI, COSMICUterine Cancer9256433 10772829 16619501, 9307275
ENSP00000361021Y65CCOSMICIntestines Cancer14724591
ENSP00000361021E7*COSMICCentral Nervous System Neoplasms11051241
ENSP00000361021L57fs*42COSMICBrain Cancer9549723
ENSP00000361021K164fs*3COSMICUterine Cancer
ENSP00000361021A121PCOSMICCentral Nervous System Neoplasms9619835
ENSP00000361021R308CCOSMICHead and Neck Cancer16344319
ENSP00000361021P169HCOSMICCentral Nervous System Neoplasms9690672
ENSP00000361021G293*COSMICUterine Cancer9326929
ENSP00000361021N323fs*21COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021A3SCOSMICUterine Cancer11156411
ENSP00000361021R335*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021G129fs*5COSMICUterine Cancer9354433
ENSP00000361021D107YCOSMICUterine Cancer11006040
ENSP00000361021R159KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021E99*COSMICUterine Cancer11585417
ENSP00000361021D115fs*19COSMICUterine Cancer18500270
ENSP00000361021Q87*COSMICProstate Cancer9661880
ENSP00000361021L57WCOSMICCentral Nervous System Neoplasms9090379
ENSP00000361021V216MCOSMICUterine Cancer9829719
ENSP00000361021H272YCOSMICProstate Cancer11234884
ENSP00000361021T131ACOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021Q17*COSMICUterine Cancer11006040
ENSP00000361021E235GCOSMICBiliary Tract Cancer21087480
ENSP00000361021E43fs*11COSMICCentral Nervous System Neoplasms9499454
ENSP00000361021R335*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021K144ICOSMICHepatocellular Carcinoma10340391
ENSP00000361021G132SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000361021E291*COSMICIntestines Cancer21103049
ENSP00000361021R189*COSMICCentral Nervous System Neoplasms12112531
ENSP00000361021G251VCOSMICUterine Cancer15069681
ENSP00000361021R142WCOSMICUterine Cancer11179477
ENSP00000361021V158LHPIOther Cancer10807691
ENSP00000361021F347fs*5COSMICCentral Nervous System Neoplasms11556543
ENSP00000361021V166LCOSMICLymphoma9787181
ENSP00000361021G129RCOSMICCentral Nervous System Neoplasms
ENSP00000361021V119DCOSMICUterine Cancer9865913
ENSP00000361021Y225*COSMICCentral Nervous System Neoplasms9331071
ENSP00000361021R234QOMIM, HPINeoplasms by Histologic Type12085208
ENSP00000361021R233*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021I122SCOSMICCentral Nervous System Neoplasms10653004
ENSP00000361021F243SCOSMICThyroid Carcinoma17317825
ENSP00000361021K197fs*2COSMICBreast Cancer12203362
ENSP00000361021K313fs*4COSMICUterine Cancer9354433
ENSP00000361021L112VCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021G36ETCGA, HPINeoplasms by Histologic Type21720365, 18772890, 9090379 16160475
ENSP00000361021M198KCOSMICUterine Cancer18757403
ENSP00000361021C296fs*11COSMICCentral Nervous System Neoplasms11939587
ENSP00000361021G44DCOSMICCentral Nervous System Neoplasms9619835
ENSP00000361021V365ICOSMICUterine Cancer10955808
ENSP00000361021S287*COSMICUterine Cancer21266528
ENSP00000361021K221fs*2COSMICUterine Cancer18757403
ENSP00000361021I300fs*7COSMICUterine Cancer18757403
ENSP00000361021F337fs*7COSMICUterine Cancer11555573
ENSP00000361021I168FCOSMICRenal Cancer10628321
ENSP00000361021Q110*COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021Y138*COSMICLung Cancer20668451
ENSP00000361021T277ITCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021Q149RCOSMICUterine Cancer15923161
ENSP00000361021*404SCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021K125ECOSMICIntestines Cancer14724591
ENSP00000361021K125*COSMICIntestines Cancer14724591
ENSP00000361021F273SCOSMICBreast Cancer21512767
ENSP00000361021T321fs*23COSMICUterine Cancer11849740
ENSP00000361021C296*COSMICUterine Cancer16160475
ENSP00000361021V369GCOSMICProstate Cancer9788441
ENSP00000361021P96LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021R15SCOSMICCentral Nervous System Neoplasms9090379
ENSP00000361021Y27DBIOMARTBreast Cancer21930507, 21930502
ENSP00000361021A148TCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021P246LDing2008Central Nervous System Neoplasms10427138, 10560660, 15195137, 18428421, 18948947, 9393744
ENSP00000361021Y29fs*25COSMICUterine Cancer17219201
ENSP00000361021V119LHPIOther Cancer10807691
ENSP00000361021Y27*COSMICCentral Nervous System Neoplasms10416987
ENSP00000361021L57WHPINeoplasms by Histologic Type9090379 9256433
ENSP00000361021H118LCOSMICMelanoma20544847
ENSP00000361021G293fs*14COSMICIntestines Cancer21103049
ENSP00000361021V119fs*15COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021V222ACOSMICHead and Neck Cancer12370746
ENSP00000361021Y174NCOSMICProstate Cancer9582022
ENSP00000361021Y76*COSMICMelanoma10766161
ENSP00000361021G36ECOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021Q298*COSMICUterine Cancer15385114
ENSP00000361021R233*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021Y346*COSMICUterine Cancer11585417
ENSP00000361021E307KCOSMICBreast Cancer22103913
ENSP00000361021S10NDing2008Lung Cancer18428421, 18948947, 9596690
ENSP00000361021I28MCOSMICIntestines Cancer19962665
ENSP00000361021E284*COSMICUterine Cancer18757403
ENSP00000361021M198fs*23COSMICUterine Cancer15385114
ENSP00000361021V255ACOSMICHepatocellular Carcinoma10340391
ENSP00000361021Q214*Ding2008Central Nervous System Neoplasms11555573, 17260012, 18428421, 18948947, 9326929, 9331072, 9354433, 9927063
ENSP00000361021E73*COSMICUterine Cancer18552176
ENSP00000361021Y177CCOSMICCentral Nervous System Neoplasms19644652
ENSP00000361021K344RCOSMICProstate Cancer11234884
ENSP00000361021T382SCOSMICProstate Cancer11234884
ENSP00000361021F145ICOSMICIntestines Cancer18781614
ENSP00000361021A121GOMIMNeoplasms by Histologic Type11801303
ENSP00000361021S10NDing2008Neoplasms by Histologic Type18428421, 18948947, 9596690
ENSP00000361021V217ACOSMICIntestines Cancer14724591
ENSP00000361021C211*COSMICMelanoma10978354
ENSP00000361021F258fs*8COSMICUterine Cancer10746673
ENSP00000361021M199fs*22COSMICCentral Nervous System Neoplasms9690672
ENSP00000361021D187fs*12COSMICUterine Cancer11555573
ENSP00000361021V191fs*8COSMICUterine Cancer18757403
ENSP00000361021D116GCOSMICThyroid Carcinoma17317825
ENSP00000361021C124fs*10COSMICCentral Nervous System Neoplasms9393744
ENSP00000361021N212fs*9COSMICUterine Cancer11585417
ENSP00000361021Q171*COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021Q219*COSMICCentral Nervous System Neoplasms9619835
ENSP00000361021D92ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021S338fs*6COSMICUterine Cancer9354433
ENSP00000361021Y188SCOSMICGastric Cancer12695913
ENSP00000361021I33fs*21COSMICUterine Cancer9829719
ENSP00000361021L186fs*13COSMICCentral Nervous System Neoplasms9619835
ENSP00000361021F341VCOSMICCentral Nervous System Neoplasms11051241
ENSP00000361021F271SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021Y155CCOSMICCentral Nervous System Neoplasms11051241
ENSP00000361021Y65*COSMICUterine Cancer15069681
ENSP00000361021S59PCOSMICBreast Cancer9510470
ENSP00000361021F56VCOSMICOvarian Cancer11395387
ENSP00000361021K221*COSMICUterine Cancer21266528
ENSP00000361021E40*COSMICUterine Cancer9354433
ENSP00000361021M1TCOSMICIntestines Cancer21103049
ENSP00000361021D58YCOSMICCentral Nervous System Neoplasms9484844
ENSP00000361021G36*COSMICUterine Cancer11555573
ENSP00000361021L23FCOSMICCentral Nervous System Neoplasms9393744
ENSP00000361021P281fs*10COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021K197*COSMICCentral Nervous System Neoplasms
ENSP00000361021P204fs*17COSMICCentral Nervous System Neoplasms
ENSP00000361021V119FBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000361021L152VCOSMICCentral Nervous System Neoplasms9499454
ENSP00000361021N276fs*15COSMICUterine Cancer10657903
ENSP00000361021Y180*COSMICLung Cancer20018398
ENSP00000361021W111*COSMICCentral Nervous System Neoplasms10666371
ENSP00000361021N48ICOSMICOther Cancer11108659
ENSP00000361021S59*COSMICUterine Cancer9307275
ENSP00000361021K263*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021M205ICOSMICHead and Neck Cancer11801303
ENSP00000361021Q214*Ding2008Lung Cancer11555573, 17260012, 18428421, 18948947, 9326929, 9331072, 9354433, 9927063
ENSP00000361021R173fs*10COSMICCentral Nervous System Neoplasms9393744
ENSP00000361021N63fs*36COSMICUterine Cancer9354433
ENSP00000361021C304GCOSMICHepatocellular Carcinoma15532706
ENSP00000361021Y46*COSMICCentral Nervous System Neoplasms11939587
ENSP00000361021H61RCOSMICCentral Nervous System Neoplasms9681833
ENSP00000361021D116fs*18COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021D162HCOSMICLymphoma9787181
ENSP00000361021R234QOMIMBrain Cancer12085208
ENSP00000361021L318FCOSMICThyroid Carcinoma17317825
ENSP00000361021L146VCOSMICUterine Cancer10746673
ENSP00000361021G129RHPINeoplasms by Histologic Type9072974 9256433 9331071 10866302
ENSP00000361021E73VCOSMICUterine Cancer10657903
ENSP00000361021Y178fs*5COSMICUterine Cancer18757403
ENSP00000361021F90SCOSMICUterine Cancer9307275
ENSP00000361021F241fs*15COSMICUterine Cancer9307275
ENSP00000361021S287fs*4COSMICCentral Nervous System Neoplasms
ENSP00000361021I101TCOSMICCentral Nervous System Neoplasms9393744
ENSP00000361021D331fs*13COSMICUterine Cancer10746673
ENSP00000361021L345QCOSMICCentral Nervous System Neoplasms9331071
ENSP00000361021W274fs*2COSMICUterine Cancer11555573
ENSP00000361021Y68CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021C83*COSMICUterine Cancer12015762
ENSP00000361021V290fs*1COSMICUterine Cancer
ENSP00000361021L108RCOSMICBreast Cancer19593635
ENSP00000361021R130*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021R14fs*10COSMICUterine Cancer9354433
ENSP00000361021D252YCOSMICCentral Nervous System Neoplasms9393744
ENSP00000361021N49TCOSMICCentral Nervous System Neoplasms16410744
ENSP00000361021W111RDing2008, COSMICCentral Nervous System Neoplasms11939587, 18428421, 18948947
ENSP00000361021L139FCOSMICCentral Nervous System Neoplasms11556543
ENSP00000361021G127VCOSMICUterine Cancer15069681
ENSP00000361021T78ACOSMICCentral Nervous System Neoplasms11678426
ENSP00000361021Q214*Ding2008, COSMICUterine Cancer11555573, 17260012, 18428421, 18948947, 9326929, 9331072, 9354433, 9927063
ENSP00000361021A86PCOSMICIntestines Cancer17932254
ENSP00000361021T131ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021C105FCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021K128NCOSMICCentral Nervous System Neoplasms12507139
ENSP00000361021L345QHPINeoplasms by Histologic Type10468583 9331071 10866302
ENSP00000361021S179ICOSMICUterine Cancer10851265
ENSP00000361021K6RCOSMICOther Cancer10955808
ENSP00000361021E235*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021T160ITCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021K267fs*9COSMICOvarian Cancer19349352
ENSP00000361021A79fs*20COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021S227FCOSMICUterine Cancer9829719
ENSP00000361021S113RCOSMICUterine Cancer15385114
ENSP00000361021N334YCOSMICSarcoma22052239
ENSP00000361021W274*COSMICCentral Nervous System Neoplasms10560660
ENSP00000361021R161KCOSMICBreast Cancer20300775
ENSP00000361021C71fs*28COSMICOvarian Cancer17418409
ENSP00000361021Q17PCOSMICCentral Nervous System Neoplasms10666371
ENSP00000361021N311fs*6COSMICUterine Cancer18757403
ENSP00000361021F238LCOSMICCentral Nervous System Neoplasms19963122
ENSP00000361021G230fs*26COSMICCentral Nervous System Neoplasms10980610
ENSP00000361021I253NCOSMICCentral Nervous System Neoplasms10096247
ENSP00000361021P204TCOSMICGastric Cancer12695913
ENSP00000361021T131fs*3COSMICUterine Cancer10746673
ENSP00000361021E291KCOSMICUterine Cancer15923161
ENSP00000361021S170ICOSMICCentral Nervous System Neoplasms9393744
ENSP00000361021E242*COSMICCentral Nervous System Neoplasms21163964
ENSP00000361021V53GCOSMICRenal Cancer11146448
ENSP00000361021A34DCOSMICUterine Cancer21266528
ENSP00000361021K66NCOSMICCentral Nervous System Neoplasms12112531
ENSP00000361021N292fs*15COSMICUterine Cancer11854177
ENSP00000361021Y177*COSMICCentral Nervous System Neoplasms18772890
ENSP00000361021L23*COSMICUterine Cancer18757403
ENSP00000361021E242KCOSMICUterine Cancer15069681
ENSP00000361021Q214*Ding2008Skin Cancer11555573, 17260012, 18428421, 18948947, 9326929, 9331072, 9354433, 9927063
ENSP00000361021N94ICOSMICHead and Neck Cancer11801303
ENSP00000361021S10NCOSMICLymphoma9596690
ENSP00000361021G20ECOSMICUterine Cancer9829719
ENSP00000361021K13ECOSMICCentral Nervous System Neoplasms9619835
ENSP00000361021I32fs*22COSMICUterine Cancer9326929
ENSP00000361021T401ICOSMICCentral Nervous System Neoplasms12168116
ENSP00000361021E284KCOSMICUterine Cancer11190805
ENSP00000361021L139*COSMICMelanoma10651986
ENSP00000361021E314fs*3COSMICCentral Nervous System Neoplasms9619835
ENSP00000361021V85GCOSMICIntestines Cancer21103049
ENSP00000361021L325VCOSMICHead and Neck Cancer17052259
ENSP00000361021P246LCOSMICMelanoma15195137
ENSP00000361021K6IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000361021P213HCOSMICCentral Nervous System Neoplasms16410744
ENSP00000361021V175LCOSMICOvarian Cancer21720365
ENSP00000361021Y68*COSMICUterine Cancer18757403
ENSP00000361021C211YCOSMICCentral Nervous System Neoplasms10427138
ENSP00000361021L181PCOSMICIntestines Cancer18781614
ENSP00000361021C250*COSMICUterine Cancer9326929
ENSP00000361021L25FCOSMICCentral Nervous System Neoplasms18772396
ENSP00000361021N48fs*6COSMICUterine Cancer11849740
ENSP00000361021R173CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021K62RCOSMICIntestines Cancer14724591
ENSP00000361021E114*COSMICUterine Cancer12015762
ENSP00000361021R172WCOSMICIntestines Cancer21103049
ENSP00000361021F271fs*5COSMICUterine Cancer10657903
ENSP00000361021G165RHPINeoplasms by Histologic Type9256433 9331071 10866302
ENSP00000361021E150QCOSMICIntestines Cancer14724591
ENSP00000361021A79TCOSMICMelanoma11297763
ENSP00000361021P96LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021G143fs*4COSMICOvarian Cancer19349352
ENSP00000361021P244SCOSMICMelanoma10881743
ENSP00000361021I135fs*12COSMICCentral Nervous System Neoplasms9426052
ENSP00000361021K263*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021R159KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021K147RCOSMICThyroid Carcinoma17317825
ENSP00000361021L193PTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021G132VOMIM, HPIOther Cancer16752378 12471211
ENSP00000361021T167SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000361021A126TCOSMICCentral Nervous System Neoplasms9393744
ENSP00000361021C71YCOSMICCentral Nervous System Neoplasms11051241
ENSP00000361021M134LHPIProstate Cancer9072974 9256433 10866302
ENSP00000361021R84GCOSMICOther Cancer10955808
ENSP00000361021E157*COSMICMelanoma20544847
ENSP00000361021F215fs*6COSMICUterine Cancer18084252
ENSP00000361021D153YCOSMICIntestines Cancer14724591
ENSP00000361021Q149*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021Y138CCOSMICLung Cancer9794233
ENSP00000361021W274GCOSMICCentral Nervous System Neoplasms10560660
ENSP00000361021T26PCOSMICUterine Cancer11555573
ENSP00000361021D52NCOSMICMelanoma10978354
ENSP00000361021Y178*COSMICUterine Cancer18757403
ENSP00000361021N184ICOSMICCentral Nervous System Neoplasms10427138
ENSP00000361021Y88CCOSMICHead and Neck Cancer11801303
ENSP00000361021P246fs*10COSMICUterine Cancer9326929
ENSP00000361021Y177*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000361021R130GBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000361021V275fs*1COSMICBreast Cancer19593635
ENSP00000361021K164*COSMICLung Cancer9696041
ENSP00000361021Q171HCOSMICCentral Nervous System Neoplasms9619835
ENSP00000361021E288KCOSMICOther Cancer10955808
ENSP00000361021L42RCOSMICCentral Nervous System Neoplasms9090379
ENSP00000361021K237fs*19COSMICLung Cancer9598803
ENSP00000361021P103SCOSMICIntestines Cancer18669866
ENSP00000361021H185DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361021P246LDing2008Lung Cancer10427138, 10560660, 15195137, 18428421, 18948947, 9393744
ENSP00000361021E91*COSMICUterine Cancer10657903
ENSP00000361021L182FCOSMICPancreatic Cancer11021813
ENSP00000361021G230RCOSMICHead and Neck Cancer12370746
ENSP00000361021M134ICOSMICUterine Cancer21984976
ENSP00000361021K254ECOSMICHead and Neck Cancer12370746
ENSP00000361021F81CCOSMICUterine Cancer11190805
ENSP00000361021K60*COSMICCentral Nervous System Neoplasms15517868
ENSP00000361021I32delCOSMICMelanoma20544847
ENSP00000361021W111RDing2008Lung Cancer11939587, 18428421, 18948947

Differential expressed protein
PTEN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S380EPDHYRYsDTTDSDPPEL21819957PhosphoSitePlus
S380EPDHYRYsDTTDSDPKaposi's sarcoma21819957PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANPTEN_HUMANkinase -> substrateRegPhos
CSK21_HUMANPTEN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANPTEN_HUMANkinase -> substrateRegPhos
ROCK1_HUMANPTEN_HUMANkinase -> substrateRegPhos
LCK_HUMANPTEN_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANPTEN_HUMANkinase -> substrateHPRD; RegPhos
CSK22_HUMANPTEN_HUMANkinase -> substrateHPRD
GSK3B_HUMANPTEN_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PTEN_HUMANFAK1_HUMANphosphatase -> substrateKEGG
PTEN_HUMANCDIPT_HUMANenzyme catalysisKEGG
PTEN_HUMANPI3R5_HUMANenzyme catalysisKEGG
PTEN_HUMANMTM1_HUMANenzyme catalysisKEGG
PI3R5_HUMANPTEN_HUMANenzyme catalysisKEGG
PTEN_HUMANSHIP1_HUMANenzyme catalysisKEGG
PTEN_HUMANINP4A_HUMANenzyme catalysisKEGG
PLCD3_HUMANPTEN_HUMANenzyme catalysisKEGG
PTEN_HUMANFYV1_HUMANenzyme catalysisKEGG
PTEN_HUMANPLCD3_HUMANenzyme catalysisKEGG
SHIP1_HUMANPTEN_HUMANenzyme catalysisKEGG
PTEN_HUMANI5P2_HUMANenzyme catalysisKEGG
PI51C_HUMANPTEN_HUMANenzyme catalysisKEGG
I5P2_HUMANPTEN_HUMANenzyme catalysisKEGG
PTEN_HUMANPI4KA_HUMANenzyme catalysisKEGG
PI42A_HUMANPTEN_HUMANenzyme catalysisKEGG
PTEN_HUMANPI51C_HUMANenzyme catalysisKEGG
PTEN_HUMANAKT3_HUMANotherKEGG
MAGI3_HUMANPTEN_HUMANotherKEGG
P53_HUMANPTEN_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05222Small cell lung cancer
hsa04530Tight junction
hsa04510Focal adhesion
hsa04150mTOR signaling pathway
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05218Melanoma
hsa05214Glioma
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
hsa05213Endometrial cancer
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIEAmolecular_function
GO:0042995cell projectionIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0042711maternal behaviorIEAbiological_process
GO:0007626locomotory behaviorISSbiological_process
GO:0030165PDZ domain bindingIPImolecular_function
GO:0007626locomotory behaviorIEAbiological_process
GO:0060179male mating behaviorIEAbiological_process
GO:2000808negative regulation of synaptic vesicle clusteringISSbiological_process
GO:0097107postsynaptic density assemblyIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0048854brain morphogenesisISSbiological_process
GO:0045792negative regulation of cell sizeISSbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0090394negative regulation of excitatory postsynaptic memIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051895negative regulation of focal adhesion assemblyIMPbiological_process
GO:0004721phosphoprotein phosphatase activityIDAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0010997anaphase-promoting complex bindingIPImolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0007611learning or memoryISSbiological_process
GO:0006917induction of apoptosisISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0016605PML bodyIEAcellular_component
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0060997dendritic spine morphogenesisIEAbiological_process
GO:0060074synapse maturationISSbiological_process
GO:0090071negative regulation of ribosome biogenesisIEAbiological_process
GO:0060074synapse maturationIEAbiological_process
GO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphaIDAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0031658negative regulation of cyclin-dependent protein kiIDAbiological_process
GO:0032535regulation of cellular component sizeISSbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0033555multicellular organismal response to stressISSbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0043542endothelial cell migrationIEAbiological_process
GO:0032535regulation of cellular component sizeIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0046621negative regulation of organ growthISSbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0035749myelin sheath adaxonal regionIEAcellular_component
GO:0032286central nervous system myelin maintenanceIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIDAmolecular_function
GO:0007092activation of mitotic anaphase-promoting complex aIDAbiological_process
GO:0048853forebrain morphogenesisIEAbiological_process
GO:0043220Schmidt-Lanterman incisureISScellular_component
GO:0051898negative regulation of protein kinase B signaling IMPbiological_process
GO:0007416synapse assemblyISSbiological_process
GO:0046856phosphatidylinositol dephosphorylationIMPbiological_process
GO:0060024rhythmic synaptic transmissionIEAbiological_process
GO:0051800phosphatidylinositol-3,4-bisphosphate 3-phosphatasIDAmolecular_function
GO:0031642negative regulation of myelinationIEAbiological_process
GO:0030336negative regulation of cell migrationIMPbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0016477cell migrationISSbiological_process
GO:0010975regulation of neuron projection developmentIEAbiological_process
GO:2000808negative regulation of synaptic vesicle clusteringIEAbiological_process
GO:0061002negative regulation of dendritic spine morphogenesIEAbiological_process
GO:0045792negative regulation of cell sizeIEAbiological_process
GO:0051717inositol-1,3,4,5-tetrakisphosphate 3-phosphatase aIDAmolecular_function
GO:0035176social behaviorIEAbiological_process
GO:0008138protein tyrosine/serine/threonine phosphatase actiIEAmolecular_function
GO:0002902regulation of B cell apoptotic processIEAbiological_process
GO:0043491protein kinase B signaling cascadeISSbiological_process
GO:0035749myelin sheath adaxonal regionISScellular_component
GO:0090344negative regulation of cell agingIEAbiological_process
GO:0021542dentate gyrus developmentISSbiological_process
GO:0060134prepulse inhibitionISSbiological_process
GO:0060736prostate gland growthIEAbiological_process
GO:0032286central nervous system myelin maintenanceISSbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0006470protein dephosphorylationIDAbiological_process
GO:0007270neuron-neuron synaptic transmissionIEAbiological_process
GO:2000463positive regulation of excitatory postsynaptic memIEAbiological_process
GO:0043005neuron projectionISScellular_component
GO:0097105presynaptic membrane assemblyISSbiological_process
GO:0009898internal side of plasma membraneIDAcellular_component
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0090394negative regulation of excitatory postsynaptic memISSbiological_process
GO:0007092activation of mitotic anaphase-promoting complex aIEAbiological_process
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0033555multicellular organismal response to stressIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0061002negative regulation of dendritic spine morphogenesISSbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:2000060positive regulation of protein ubiquitination invoIDAbiological_process
GO:0045475locomotor rhythmISSbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0060024rhythmic synaptic transmissionISSbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0097107postsynaptic density assemblyISSbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:2000134negative regulation of G1/S transition of mitotic IDAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0031647regulation of protein stabilityIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0060997dendritic spine morphogenesisISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0050771negative regulation of axonogenesisISSbiological_process
GO:0035176social behaviorISSbiological_process
GO:0004438phosphatidylinositol-3-phosphatase activityIDAmolecular_function
GO:0046855inositol phosphate dephosphorylationIDAbiological_process
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0021955central nervous system neuron axonogenesisISSbiological_process
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0014067negative regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0021542dentate gyrus developmentIEAbiological_process
GO:0060134prepulse inhibitionIEAbiological_process
GO:0048853forebrain morphogenesisISSbiological_process
GO:0007507heart developmentISSbiological_process
GO:0033032regulation of myeloid cell apoptotic processIEAbiological_process
GO:0050771negative regulation of axonogenesisIEAbiological_process
GO:0045475locomotor rhythmIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0021955central nervous system neuron axonogenesisIEAbiological_process
GO:0007270neuron-neuron synaptic transmissionISSbiological_process
GO:0043220Schmidt-Lanterman incisureIEAcellular_component
GO:0048854brain morphogenesisIEAbiological_process
GO:0048738cardiac muscle tissue developmentIEAbiological_process
GO:0097105presynaptic membrane assemblyIEAbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0010975regulation of neuron projection developmentISSbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007416synapse assemblyIEAbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:2000463positive regulation of excitatory postsynaptic memISSbiological_process
GO:0004722protein serine/threonine phosphatase activityIDAmolecular_function
GO:0050821protein stabilizationIDAbiological_process
GO:0007417central nervous system developmentISSbiological_process
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process