Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ABCA1_HUMAN
Description:ATP-binding cassette, sub-family A (ABC1), member 1 [Source:HGNC Symbol;Acc:29]
Location:chr9 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1586MTGLDtKNNVKHPRD
S1141ESSLSsCRNSSRegPhos
T1582LGRFMtGLDTKHPRD
T1243GISETtLEEIFPhosphoSitePlus
T1242YGISEtTLEEICK2_alphaphosphoELM
T1242YGISEtTLEEIPhosphoSitePlus
S1042MQRKLsVALAFTM; ABC_tranPhosphoSitePlus
S1042MQRKLsVALAFPRKACAHPRD
T1243GISETtLEEIFCK2a1(CK2 alphaRegPhos
T1243GISETtLEEIFCK2_alphaphosphoELM
T1286CLRPFtEDDAAphosphoELM; RegPhos
S1536RYGGFsLGVSNABC2_membrane_3PhosphoSitePlus
S1042MQRKLsVALAFPKACaRegPhos
S1255KVAEEsGVDAECK2_alphaphosphoELM
S1540FSLGVsNTQALABC2_membrane_3; GspL_CPhosphoSitePlus
S2054NKRKLsTAMALPKACaRegPhos
S1042MQRKLsVALAFPKA_groupphosphoELM; RegPhos
S1147CRNSSsTVSYLRegPhos
S2054NKRKLsTAMALPKA_groupphosphoELM; RegPhos
S1255KVAEEsGVDAECK2a1(CK2 alphaRegPhos
S1255KVAEEsGVDAEPhosphoSitePlus
T1242YGISEtTLEEICK2a1(CK2 alphaRegPhos
T1305PESREtDLLSGphosphoELM; RegPhos
S2101SVVLTsHSMEEPhosphoSitePlus
S2054NKRKLsTAMALPRKACAHPRD
Y1206GHELTyVLPYEPhosphoSitePlus
Y1508RNISDyLVKTYABC2_membrane_3PhosphoSitePlus
S2054NKRKLsTAMALABC_tranPhosphoSitePlus

Dephosphorylation site
ABCA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363868W416*COSMICBreast Cancer20668451
ENSP00000363868A1544PCOSMICMelanoma21499247
ENSP00000363868W685*COSMICOvarian Cancer21720365
ENSP00000363868V1207LCOSMICLung Cancer20668451
ENSP00000363868A465VCOSMICOvarian Cancer21720365
ENSP00000363868M433LCOSMICOvarian Cancer21720365
ENSP00000363868Y1990CCOSMICLung Cancer20668451
ENSP00000363868A2109THPIColorectal Cancer12763760 16959974
ENSP00000363868A1407TCOSMICIntestines Cancer16959974
ENSP00000363868A2109TSjoblom2006, COSMICIntestines Cancer12763760, 16959974, 12763760, 16959974
ENSP00000363868E1253KCOSMICOvarian Cancer21720365
ENSP00000363868A1407THPIColorectal Cancer12763760 16959974
ENSP00000363868A1407TSjoblom2006Intestines Cancer12763760, 16959974
ENSP00000363868D917YHPIColorectal Cancer12763760 16959974
ENSP00000363868T970ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000363868R579LCOSMICHead and Neck Cancer21798897
ENSP00000363868R606SCOSMICLung Cancer20668451
ENSP00000363868R230CBIOMARTBreast Cancer21930507, 21930502
ENSP00000363868E210DHPIColorectal Cancer12763760 16959974
ENSP00000363868E210DSjoblom2006, COSMICIntestines Cancer12763760, 16959974, 12763760, 16959974
ENSP00000363868D917YSjoblom2006, COSMICIntestines Cancer12763760, 16959974, 12763760, 16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000363868Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3915169874

Hyperphosphorylation site
ABCA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANABCA1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANABCA1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANABCA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04975Fat digestion and absorption
hsa02010ABC transporters

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010887negative regulation of cholesterol storageTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0008509anion transmembrane transporter activityISSmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0008509anion transmembrane transporter activityIEAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0005887integral to plasma membraneIEAcellular_component
GO:0010875positive regulation of cholesterol effluxIEAbiological_process
GO:0005548phospholipid transporter activityIEAmolecular_function
GO:0033344cholesterol effluxIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIMPbiological_process
GO:0006820anion transportIEAbiological_process
GO:0055098response to low-density lipoprotein particle stimuIEPbiological_process
GO:0060155platelet dense granule organizationIMPbiological_process
GO:0050702interleukin-1 beta secretionIMPbiological_process
GO:0033700phospholipid effluxIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045332phospholipid translocationIEAbiological_process
GO:0015485cholesterol bindingICmolecular_function
GO:0010745negative regulation of macrophage derived foam celTASbiological_process
GO:0007040lysosome organizationIDAbiological_process
GO:0045335phagocytic vesicleIDAcellular_component
GO:0019905syntaxin bindingIPImolecular_function
GO:0043691reverse cholesterol transportIEAbiological_process
GO:0032489regulation of Cdc42 protein signal transductionIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005548phospholipid transporter activityIDAmolecular_function
GO:0017127cholesterol transporter activityIDAmolecular_function
GO:0008203cholesterol metabolic processIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0034380high-density lipoprotein particle assemblyIMPbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0002790peptide secretionIEAbiological_process
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0042157lipoprotein metabolic processIEAbiological_process
GO:0006911phagocytosis, engulfmentIEAbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0030139endocytic vesicleIDAcellular_component
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0033344cholesterol effluxIDAbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0034185apolipoprotein bindingIPImolecular_function
GO:0017127cholesterol transporter activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0031267small GTPase bindingIPImolecular_function
GO:0042158lipoprotein biosynthetic processIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0055091phospholipid homeostasisIMPbiological_process
GO:0038027apolipoprotein A-I-mediated signaling pathwayIDAbiological_process
GO:0034616response to laminar fluid shear stressIEPbiological_process
GO:0016197endosomal transportIDAbiological_process
GO:0032367intracellular cholesterol transportIMPbiological_process
GO:0034188apolipoprotein A-I receptor activityIDAmolecular_function
GO:0034186apolipoprotein A-I bindingIPImolecular_function
GO:0042632cholesterol homeostasisIDAbiological_process
GO:0006497protein lipidationIEAbiological_process
GO:0033700phospholipid effluxIDAbiological_process
GO:0043691reverse cholesterol transportIMPbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005543phospholipid bindingICmolecular_function
GO:0008203cholesterol metabolic processIEAbiological_process