| UniProt/SwissProt ID: | GYS1_HUMAN |
| Description: | glycogen synthase 1 (muscle) [Source:HGNC Symbol;Acc:4706] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S710 | GSKRNsVDTAT | PRKACA | HPRD |
| S652 | SLSRHsSPHQS | Glycogen_syn | PhosphoSitePlus |
| S8 | LNRTLsMSSLP | PKACa | RegPhos |
| Y405 | FGRKLyESLLV | Glycogen_syn | PhosphoSitePlus |
| S698 | WPRRAsCTSST | PhosphoSitePlus; RegPhos | |
| Y102 | KGCKVyFGRWL | Glycogen_syn | PhosphoSitePlus |
| S647 | VPPSPsLSRHS | Glycogen_syn | PhosphoSitePlus |
| S645 | ASVPPsPSLSR | GSK3B | HPRD; RegPhos |
| T715 | SVDTAtSSSLS | PhosphoSitePlus; HPRD | |
| S641 | YPRPAsVPPSP | Glycogen_syn | PhosphoSitePlus |
| T713 | RNSVDtATSSS | PhosphoSitePlus | |
| S645 | ASVPPsPSLSR | Glycogen_syn | PhosphoSitePlus |
| S653 | LSRHSsPHQSE | Glycogen_syn | PhosphoSitePlus |
| S641 | YPRPAsVPPSP | phosphoELM; RegPhos | |
| S645 | ASVPPsPSLSR | phosphoELM; RegPhos | |
| S647 | VPPSPsLSRHS | CK2a1 | RegPhos |
| S702 | ASCTSsTSGSK | HPRD | |
| S641 | YPRPAsVPPSP | GSK3B | HPRD; RegPhos |
| S10 | RTLSMsSLPGL | PhosphoSitePlus | |
| S653 | LSRHSsPHQSE | GSK3B | HPRD; RegPhos |
| S704 | CTSSTsGSKRN | HPRD | |
| S649 | PSPSLsRHSSP | GSK-3_beta | phosphoELM |
| S649 | PSPSLsRHSSP | phosphoELM; RegPhos | |
| S730 | PLSPTsSLGEE | HPRD | |
| S718 | TATSSsLSTPS | PhosphoSitePlus; HPRD | |
| S653 | LSRHSsPHQSE | CK2a1 | RegPhos |
| S647 | VPPSPsLSRHS | CSNK2A1 | HPRD |
| T729 | EPLSPtSSLGE | HPRD | |
| S647 | VPPSPsLSRHS | phosphoELM | |
| S641 | YPRPAsVPPSP | GSK3B(GSK3 beta | RegPhos |
| S716 | VDTATsSSLST | PhosphoSitePlus; HPRD | |
| S412 | SLLVGsLPDMN | Glycogen_syn | PhosphoSitePlus |
| T713 | RNSVDtATSSS | CSNK2A1 | HPRD |
| S8 | LNRTLsMSSLP | PKA_group | RegPhos |
| Y636 | AQGYRyPRPAS | HPRD; phosphoELM | |
| S412 | SLLVGsLPDMN | HPRD | |
| Y675 | EDGERyDEDEE | PhosphoSitePlus | |
| T6 | MPLNRtLSMSS | PhosphoSitePlus | |
| S8 | LNRTLsMSSLP | PhosphoSitePlus | |
| S8 | LNRTLsMSSLP | PRKACA | HPRD |
| S647 | VPPSPsLSRHS | CK2a1-rs | RegPhos |
| S657 | SSPHQsEDEED | Glycogen_syn | PhosphoSitePlus |
| T713 | RNSVDtATSSS | CK2a1-rs | RegPhos |
| S10 | RTLSMsSLPGL | CK2a1 | RegPhos |
| T700 | RRASCtSSTSG | HPRD | |
| S727 | PSEPLsPTSSL | PhosphoSitePlus; HPRD | |
| Y604 | KYLGRyYMSAR | Glycogen_syn | PhosphoSitePlus |
| S698 | WPRRAsCTSST | CK2a1 | RegPhos |
| S701 | RASCTsSTSGS | CSNK2A1 | HPRD |
| S649 | PSPSLsRHSSP | GSK3B(GSK3 beta | RegPhos |
| S731 | LSPTSsLGEER | PhosphoSitePlus | |
| Y44 | KVGGIyTVLQT | Glycogen_syn | PhosphoSitePlus |
| S710 | GSKRNsVDTAT | PKACa | RegPhos |
| S645 | ASVPPsPSLSR | GSK-3_beta | phosphoELM |
| S701 | RASCTsSTSGS | CK2a1 | RegPhos |
| T721 | SSSLStPSEPL | PhosphoSitePlus | |
| S698 | WPRRAsCTSST | CSNK2A1 | HPRD |
| S657 | SSPHQsEDEED | HPRD; RegPhos | |
| S10 | RTLSMsSLPGL | CSNK2A1 | HPRD |
| S701 | RASCTsSTSGS | CK2a1-rs | RegPhos |
| S641 | YPRPAsVPPSP | GSK-3_beta | phosphoELM |
| S653 | LSRHSsPHQSE | CK2a1-rs | RegPhos |
| S720 | TSSSLsTPSEP | HPRD | |
| S649 | PSPSLsRHSSP | GSK3B | HPRD; RegPhos |
| S649 | PSPSLsRHSSP | Glycogen_syn | PhosphoSitePlus |
| S731 | LSPTSsLGEE | HPRD | |
| S710 | GSKRNsVDTAT | PhosphoSitePlus; RegPhos | |
| S10 | RTLSMsSLPGL | CK2a1-rs | RegPhos |
| S652 | SLSRHsSPHQS | CK2a1 | RegPhos |
| S717 | DTATSsSLSTP | PhosphoSitePlus; HPRD | |
| S652 | SLSRHsSPHQS | CSNK2A1 | HPRD |
| S645 | ASVPPsPSLSR | GSK3B(GSK3 beta | RegPhos |
| S11 | TLSMSsLPGLE | PhosphoSitePlus; RegPhos | |
| S653 | LSRHSsPHQSE | RegPhos | |
| T713 | RNSVDtATSSS | CK2a1 | RegPhos |
| S652 | SLSRHsSPHQS | CK2a1-rs | RegPhos |
| S653 | LSRHSsPHQSE | CSNK2A1 | HPRD |
| S698 | WPRRAsCTSST | CK2a1-rs | RegPhos |
| Dephosphorylation site |
| GYS1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000317904 | N350T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000317904 | Q388* | COSMIC | Skin Cancer | 21984974 | ENSP00000317904 | L553F | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| GYS1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GYS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | GYS1_HUMAN | kinase -> substrate | RegPhos |
| GSK3B_HUMAN | GYS1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CSK21_HUMAN | GYS1_HUMAN | kinase -> substrate | HPRD |
| KPCA_HUMAN | GYS1_HUMAN | kinase -> substrate | HPRD |
| PP1A_HUMAN | GYS1_HUMAN | phosphatase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00500 | Starch and sucrose metabolism |
| hsa04910 | Insulin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016234 | inclusion body | IEA | cellular_component |
| GO:0005977 | glycogen metabolic process | IEA | biological_process |
| GO:0005978 | glycogen biosynthetic process | IEA | biological_process |
| GO:0005536 | glucose binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004373 | glycogen (starch) synthase activity | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | glucose metabolic process | TAS | biological_process |
| GO:0009058 | biosynthetic process | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007507 | heart development | IEA | biological_process |