Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GYS1_HUMAN
Description:glycogen synthase 1 (muscle) [Source:HGNC Symbol;Acc:4706]
Location:chr19 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S710GSKRNsVDTATPRKACAHPRD
S652SLSRHsSPHQSGlycogen_synPhosphoSitePlus
S8LNRTLsMSSLPPKACaRegPhos
Y405FGRKLyESLLVGlycogen_synPhosphoSitePlus
S698WPRRAsCTSSTPhosphoSitePlus; RegPhos
Y102KGCKVyFGRWLGlycogen_synPhosphoSitePlus
S647VPPSPsLSRHSGlycogen_synPhosphoSitePlus
S645ASVPPsPSLSRGSK3BHPRD; RegPhos
T715SVDTAtSSSLSPhosphoSitePlus; HPRD
S641YPRPAsVPPSPGlycogen_synPhosphoSitePlus
T713RNSVDtATSSSPhosphoSitePlus
S645ASVPPsPSLSRGlycogen_synPhosphoSitePlus
S653LSRHSsPHQSEGlycogen_synPhosphoSitePlus
S641YPRPAsVPPSPphosphoELM; RegPhos
S645ASVPPsPSLSRphosphoELM; RegPhos
S647VPPSPsLSRHSCK2a1RegPhos
S702ASCTSsTSGSKHPRD
S641YPRPAsVPPSPGSK3BHPRD; RegPhos
S10RTLSMsSLPGLPhosphoSitePlus
S653LSRHSsPHQSEGSK3BHPRD; RegPhos
S704CTSSTsGSKRNHPRD
S649PSPSLsRHSSPGSK-3_betaphosphoELM
S649PSPSLsRHSSPphosphoELM; RegPhos
S730PLSPTsSLGEEHPRD
S718TATSSsLSTPSPhosphoSitePlus; HPRD
S653LSRHSsPHQSECK2a1RegPhos
S647VPPSPsLSRHSCSNK2A1HPRD
T729EPLSPtSSLGEHPRD
S647VPPSPsLSRHSphosphoELM
S641YPRPAsVPPSPGSK3B(GSK3 betaRegPhos
S716VDTATsSSLSTPhosphoSitePlus; HPRD
S412SLLVGsLPDMNGlycogen_synPhosphoSitePlus
T713RNSVDtATSSSCSNK2A1HPRD
S8LNRTLsMSSLPPKA_groupRegPhos
Y636AQGYRyPRPASHPRD; phosphoELM
S412SLLVGsLPDMNHPRD
Y675EDGERyDEDEEPhosphoSitePlus
T6MPLNRtLSMSSPhosphoSitePlus
S8LNRTLsMSSLPPhosphoSitePlus
S8LNRTLsMSSLPPRKACAHPRD
S647VPPSPsLSRHSCK2a1-rsRegPhos
S657SSPHQsEDEEDGlycogen_synPhosphoSitePlus
T713RNSVDtATSSSCK2a1-rsRegPhos
S10RTLSMsSLPGLCK2a1RegPhos
T700RRASCtSSTSGHPRD
S727PSEPLsPTSSLPhosphoSitePlus; HPRD
Y604KYLGRyYMSARGlycogen_synPhosphoSitePlus
S698WPRRAsCTSSTCK2a1RegPhos
S701RASCTsSTSGSCSNK2A1HPRD
S649PSPSLsRHSSPGSK3B(GSK3 betaRegPhos
S731LSPTSsLGEERPhosphoSitePlus
Y44KVGGIyTVLQTGlycogen_synPhosphoSitePlus
S710GSKRNsVDTATPKACaRegPhos
S645ASVPPsPSLSRGSK-3_betaphosphoELM
S701RASCTsSTSGSCK2a1RegPhos
T721SSSLStPSEPLPhosphoSitePlus
S698WPRRAsCTSSTCSNK2A1HPRD
S657SSPHQsEDEEDHPRD; RegPhos
S10RTLSMsSLPGLCSNK2A1HPRD
S701RASCTsSTSGSCK2a1-rsRegPhos
S641YPRPAsVPPSPGSK-3_betaphosphoELM
S653LSRHSsPHQSECK2a1-rsRegPhos
S720TSSSLsTPSEPHPRD
S649PSPSLsRHSSPGSK3BHPRD; RegPhos
S649PSPSLsRHSSPGlycogen_synPhosphoSitePlus
S731LSPTSsLGEEHPRD
S710GSKRNsVDTATPhosphoSitePlus; RegPhos
S10RTLSMsSLPGLCK2a1-rsRegPhos
S652SLSRHsSPHQSCK2a1RegPhos
S717DTATSsSLSTPPhosphoSitePlus; HPRD
S652SLSRHsSPHQSCSNK2A1HPRD
S645ASVPPsPSLSRGSK3B(GSK3 betaRegPhos
S11TLSMSsLPGLEPhosphoSitePlus; RegPhos
S653LSRHSsPHQSERegPhos
T713RNSVDtATSSSCK2a1RegPhos
S652SLSRHsSPHQSCK2a1-rsRegPhos
S653LSRHSsPHQSECSNK2A1HPRD
S698WPRRAsCTSSTCK2a1-rsRegPhos

Dephosphorylation site
GYS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000317904N350TCOSMICOvarian Cancer21720365
ENSP00000317904Q388*COSMICSkin Cancer21984974
ENSP00000317904L553FCOSMICHead and Neck Cancer21984974

Differential expressed protein
GYS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GYS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANGYS1_HUMANkinase -> substrateRegPhos
GSK3B_HUMANGYS1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CSK21_HUMANGYS1_HUMANkinase -> substrateHPRD
KPCA_HUMANGYS1_HUMANkinase -> substrateHPRD
PP1A_HUMANGYS1_HUMANphosphatase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016234inclusion bodyIEAcellular_component
GO:0005977glycogen metabolic processIEAbiological_process
GO:0005978glycogen biosynthetic processIEAbiological_process
GO:0005536glucose bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0004373glycogen (starch) synthase activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0006006glucose metabolic processTASbiological_process
GO:0009058biosynthetic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007507heart developmentIEAbiological_process


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