Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:C1R_HUMAN
Description:complement component 1, r subcomponent [Source:HGNC Symbol;Acc:1246]
Location:chr12 p13.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S206ASGYIsSLEYPCK2_groupphosphoELM; RegPhos
Y684GCSRGyGFYTKTrypsinPhosphoSitePlus
S206ASGYIsSLEYPCK2a1-rsRegPhos
S206ASGYIsSLEYPCK2a1(CK2 alphaRegPhos
S206ASGYIsSLEYPCUBPhosphoSitePlus
Y687RGYGFyTKVLNTrypsinPhosphoSitePlus
S206ASGYIsSLEYPCK2a1RegPhos
S206ASGYIsSLEYPCK2_alphaphosphoELM
T127NEENGtIMFYKCUBPhosphoSitePlus
T118LLTFHtDFSNECUBPhosphoSitePlus

Dephosphorylation site
C1R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000290575Q260PBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000290575Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)cell lineDown0.4814729644
ENSP00000290575hepatitis C virusNormal vs. CancertissueUp19136905
ENSP00000290575Brain CancerNormal vs. CancertissueUp1.618056677
ENSP00000290575Gastric CancerNormal vs. Cancercell lineDown0.120812763
ENSP00000290575Gastric CancerNormal vs. Cancercell lineDown0.0620812763

Hyperphosphorylation site
C1R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANC1R_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
C1R_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006958complement activation, classical pathwayTASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0003824catalytic activityIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0008236serine-type peptidase activityTASmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0004252serine-type endopeptidase activityIEAmolecular_function
GO:0006955immune responseTASbiological_process
GO:0006956complement activationIEAbiological_process
GO:0005515protein bindingIPImolecular_function


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