| UniProt/SwissProt ID: | SRPK1_HUMAN |
| Description: | SRSF protein kinase 1 [Source:HGNC Symbol;Acc:11305] |
| Location: | chr6 p21.31 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S37 | GSAPHsESDLP | PhosphoSitePlus | |
| S33 | TQHRGsAPHSE | PhosphoSitePlus | |
| S222 | EEILGsDDDEQ | CK2 beta | RegPhos; SysPTM |
| S480 | NKQEEsESPVE | phosphoELM; RegPhos | |
| S393 | ENILLsVNEQY | phosphoELM | |
| Y62 | EDPNDyCKGGY | PhosphoSitePlus | |
| S555 | LFEPHsGEEYT | Pkinase | PhosphoSitePlus |
| Y117 | KSAEHyTETAL | Pkinase | PhosphoSitePlus |
| T514 | TEDIQtRQYRS | Pkinase | PhosphoSitePlus |
| S222 | EEILGsDDDEQ | CK2_alpha | phosphoELM; SysPTM |
| S587 | VAGKYsKEFFT | Pkinase | PhosphoSitePlus |
| S726 | LFEPHsGEEYT | CK2 beta | RegPhos |
| S249 | PPPSGsAVSTA | Pkinase | PhosphoSitePlus |
| S726 | LFEPHsGEEYT | CK2_beta | phosphoELM |
| S222 | EEILGsDDDEQ | CK2_group | RegPhos; SysPTM |
| S222 | EEILGsDDDEQ | phosphoELM; SysPTM | |
| T326 | PPNKMtQEKLE | Pkinase | PhosphoSitePlus |
| S726 | LFEPHsGEEYT | CK2a1(CK2 alpha | RegPhos |
| S726 | LFEPHsGEEYT | CK2_group | RegPhos |
| S134 | KSVRNsDPNDP | Pkinase | PhosphoSitePlus |
| S309 | NKQEEsESPVE | Pkinase | PhosphoSitePlus |
| S222 | EEILGsDDDEQ | CK2a1(CK2 alpha | RegPhos; SysPTM |
| T28 | QRKSEtQHRGS | PhosphoSitePlus | |
| Y365 | IEVINyTQNSN | Pkinase | PhosphoSitePlus |
| S222 | EEILGsDDDEQ | CK2_beta | phosphoELM; SysPTM |
| S726 | LFEPHsGEEYT | CK2_alpha | phosphoELM |
| S482 | QEESEsPVERP | phosphoELM; RegPhos; SysPTM | |
| S51 | EEILGsDDDEQ | PhosphoSitePlus | |
| S311 | QEESEsPVERP | Pkinase | PhosphoSitePlus |
| T373 | NSNNEtLRHKE | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| SRPK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| SRPK1_HUMAN do not have mutation site. |
| Differential expressed protein |
| SRPK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SRPK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | SRPK1_HUMAN | kinase -> substrate | RegPhos |
| SRPK1_HUMAN | MDFI_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | HNRPK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | STK16_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | SRSF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | MLX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | NOL7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | SRPK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK21_HUMAN | SRPK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | MK07_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016363 | nuclear matrix | IEA | cellular_component |
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0045071 | negative regulation of viral genome replication | IDA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0050684 | regulation of mRNA processing | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0007059 | chromosome segregation | IDA | biological_process |
| GO:0045087 | innate immune response | IC | biological_process |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0045070 | positive regulation of viral genome replication | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0035092 | sperm chromatin condensation | TAS | biological_process |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |