Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRPK1_HUMAN
Description:SRSF protein kinase 1 [Source:HGNC Symbol;Acc:11305]
Location:chr6 p21.31
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S37GSAPHsESDLPPhosphoSitePlus
S33TQHRGsAPHSEPhosphoSitePlus
S222EEILGsDDDEQCK2 betaRegPhos; SysPTM
S480NKQEEsESPVEphosphoELM; RegPhos
S393ENILLsVNEQYphosphoELM
Y62EDPNDyCKGGYPhosphoSitePlus
S555LFEPHsGEEYTPkinasePhosphoSitePlus
Y117KSAEHyTETALPkinasePhosphoSitePlus
T514TEDIQtRQYRSPkinasePhosphoSitePlus
S222EEILGsDDDEQCK2_alphaphosphoELM; SysPTM
S587VAGKYsKEFFTPkinasePhosphoSitePlus
S726LFEPHsGEEYTCK2 betaRegPhos
S249PPPSGsAVSTAPkinasePhosphoSitePlus
S726LFEPHsGEEYTCK2_betaphosphoELM
S222EEILGsDDDEQCK2_groupRegPhos; SysPTM
S222EEILGsDDDEQphosphoELM; SysPTM
T326PPNKMtQEKLEPkinasePhosphoSitePlus
S726LFEPHsGEEYTCK2a1(CK2 alphaRegPhos
S726LFEPHsGEEYTCK2_groupRegPhos
S134KSVRNsDPNDPPkinasePhosphoSitePlus
S309NKQEEsESPVEPkinasePhosphoSitePlus
S222EEILGsDDDEQCK2a1(CK2 alphaRegPhos; SysPTM
T28QRKSEtQHRGSPhosphoSitePlus
Y365IEVINyTQNSNPkinasePhosphoSitePlus
S222EEILGsDDDEQCK2_betaphosphoELM; SysPTM
S726LFEPHsGEEYTCK2_alphaphosphoELM
S482QEESEsPVERPphosphoELM; RegPhos; SysPTM
S51EEILGsDDDEQPhosphoSitePlus
S311QEESEsPVERPPkinasePhosphoSitePlus
T373NSNNEtLRHKEPkinasePhosphoSitePlus

Dephosphorylation site
SRPK1_HUMAN do not have dephosphorylation site.

Mutation site
SRPK1_HUMAN do not have mutation site.

Differential expressed protein
SRPK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SRPK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSRPK1_HUMANkinase -> substrateRegPhos
SRPK1_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANPHB2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANPRDM1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANSTK16_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANNOL7_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANSRPK1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSRPK1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016363nuclear matrixIEAcellular_component
GO:0006397mRNA processingIEAbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0045071negative regulation of viral genome replicationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0050684regulation of mRNA processingIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0007059chromosome segregationIDAbiological_process
GO:0045087innate immune responseICbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0045070positive regulation of viral genome replicationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0048024regulation of mRNA splicing, via spliceosomeTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0035092sperm chromatin condensationTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0005737cytoplasmIDAcellular_component


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