Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYUA_HUMAN
Description:synuclein, alpha (non A4 component of amyloid precursor) [Source:HGNC Symbol;Acc:11138]
Location:chr4 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y136EGYQDyEPEA_PhosphoSitePlus
Y133PSEEGyQDYEPSykRegPhos
S129AYEMPsEEGYQSynucleinPhosphoSitePlus
Y136EGYQDyEPEASYKRegPhos
Y125PDNEAyEMPSEFynphosphoELM
S9FMKGLsKAKEGGPRK6RegPhos
S129AYEMPsEEGYQCK2a1-rsRegPhos
Y133PSEEGyQDYEPSYKHPRD; phosphoELM
S129AYEMPsEEGYQBARK1RegPhos
S129AYEMPsEEGYQGPRK5(GRK5RegPhos
S87VEGAGsIAAATSynucleinPhosphoSitePlus
Y136EGYQDyEPEASykRegPhos
S87VEGAGsIAAATHPRD; phosphoELM; RegPhos
Y125PDNEAyEMPSESYKHPRD; phosphoELM; RegPhos
Y136EGYQDyEPSYKHPRD; phosphoELM
Y125PDNEAyEMPSESykRegPhos
Y125PDNEAyEMPSEPYK2RegPhos
S129AYEMPsEEGYQCK2a1RegPhos
S129AYEMPsEEGYQCK1dRegPhos
S9FMKGLsKAKEGGRK6HPRD
Y125PDNEAyEMPSESRC_groupphosphoELM
S129AYEMPsEEGYQCK2a2RegPhos
Y108EGYQDyEPSYKHPRD
S129AYEMPsEEGYQCSNK2A2HPRD
Y125PDNEAyEMPSEFYNHPRD; RegPhos
S129AYEMPsEEGYQBARK1(GRK2RegPhos
Y39KEGVLyVGSKTSynucleinPhosphoSitePlus
S129AYEMPsEEGYQphosphoELM
S129AYEMPsEEGYQCK1a(CK1 alphaRegPhos
S129AYEMPsEEGYQCK2a1(CK2 alphaRegPhos
Y125PDNEAyEMPSEPTK2BHPRD
S87VEGAGsIAAATCK2_groupRegPhos
S129AYEMPsEEGYQCK1_alphaphosphoELM
Y125PDNEAyEMPSESynucleinPhosphoSitePlus
Y125PDNEAyEMPSESrcRegPhos
S129AYEMPsEEGYQGRK5HPRD
Y125PDNEAyEMPSEphosphoELM; RegPhos
S129AYEMPsEEGYQADRBK1HPRD
S129AYEMPsEEGYQGRK-5phosphoELM
S129AYEMPsEEGYQGRK-2phosphoELM
Y133PSEEGyQDYEPPhosphoSitePlus
S87VEGAGsIAAATDYRK1AphosphoELM
S129AYEMPsEEGYQCK2_alphaphosphoELM
S129AYEMPsEEGYQCSNK2A1HPRD
Y125PDNEAyEMPSEFGRHPRD; RegPhos
S129AYEMPsEEGYQGPRK5RegPhos
Y125PDNEAyEMPSELYNHPRD; RegPhos
S129AYEMPsEEGYQCK2_groupRegPhos
S129AYEMPsEEGYQCSNK1DHPRD

Dephosphorylation site
SYUA_HUMAN do not have dephosphorylation site.

Mutation site
SYUA_HUMAN do not have mutation site.

Differential expressed protein
SYUA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S129SynucleinNEAYEMPsEEGYQDYsynucleinopathy16847063PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYParkinson's disease11813001PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYParkinson's disease14579119PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYAlzheimer's disease19889641PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYParkinson's disease22344688PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYParkinson's disease21865317PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYParkinson's disease21849493PhosphoSitePlus
S129SynucleinNEAYEMPsEEGYQDYParkinson's disease21562258PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KSYK_HUMANSYUA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANSYUA_HUMANkinase -> substrateRegPhos
JAK2_HUMANSYUA_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
FGR_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANSYUA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
LYN_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
GRK5_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ARBK1_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KC1A_HUMANSYUA_HUMANkinase -> substrateRobert H Newman (2013)
GRK6_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
CDK5_HUMANSYUA_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
CSK22_HUMANSYUA_HUMANkinase -> substrateHPRD
KC1D_HUMANSYUA_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa05012Parkinson's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionTAScellular_component
GO:0032410negative regulation of transporter activityIDAbiological_process
GO:0045502dynein bindingIPImolecular_function
GO:0001956positive regulation of neurotransmitter secretionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0031648protein destabilizationIDAbiological_process
GO:0045202synapseIEAcellular_component
GO:0034341response to interferon-gammaIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0031623receptor internalizationIDAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0051622negative regulation of norepinephrine uptakeIDAbiological_process
GO:0042393histone bindingIEAmolecular_function
GO:0007006mitochondrial membrane organizationIEAbiological_process
GO:0043030regulation of macrophage activationIEAbiological_process
GO:0042416dopamine biosynthetic processIEAbiological_process
GO:0008198ferrous iron bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0005640nuclear outer membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0032769negative regulation of monooxygenase activityIDAbiological_process
GO:0043206extracellular fibril organizationTASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005507copper ion bindingIDAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0044344cellular response to fibroblast growth factor stimIEAbiological_process
GO:0005938cell cortexIDAcellular_component
GO:0051583dopamine uptake involved in synaptic transmissionTASbiological_process
GO:0030426growth coneIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0051219phosphoprotein bindingIDAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0008017microtubule bindingIEAmolecular_function
GO:0014048regulation of glutamate secretionIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0035067negative regulation of histone acetylationIDAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0007568agingIEAbiological_process
GO:0042416dopamine biosynthetic processTASbiological_process
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0034599cellular response to oxidative stressIEAbiological_process
GO:0050812regulation of acyl-CoA biosynthetic processIEAbiological_process
GO:0048487beta-tubulin bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048488synaptic vesicle endocytosisIEAbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0048168regulation of neuronal synaptic plasticityIEAbiological_process
GO:0045920negative regulation of exocytosisIMPbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0071872cellular response to epinephrine stimulusTASbiological_process
GO:0030544Hsp70 protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0010517regulation of phospholipase activityIDAbiological_process
GO:0043205fibrilIDAcellular_component
GO:0050806positive regulation of synaptic transmissionIEAbiological_process
GO:0031092platelet alpha granule membraneIDAcellular_component
GO:0048156tau protein bindingIDAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0045963negative regulation of dopamine metabolic processIEAbiological_process
GO:0016234inclusion bodyIDAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0007268synaptic transmissionIEAbiological_process
GO:0042393histone bindingIDAmolecular_function
GO:0001921positive regulation of receptor recyclingIDAbiological_process
GO:0014059regulation of dopamine secretionTASbiological_process
GO:0030424axonIDAcellular_component
GO:0010040response to iron(II) ionIDAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0005840ribosomeIEAcellular_component
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0060732positive regulation of inositol phosphate biosynthIDAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0032496response to lipopolysaccharideIDAbiological_process
GO:0008021synaptic vesicleIEAcellular_component
GO:0001774microglial cell activationIEAbiological_process
GO:0016044cellular membrane organizationIEAbiological_process
GO:0045807positive regulation of endocytosisIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0031115negative regulation of microtubule polymerizationIDAbiological_process
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0030659cytoplasmic vesicle membraneIEAcellular_component
GO:0070495negative regulation of thrombin receptor signalingIDAbiological_process
GO:0006638neutral lipid metabolic processIEAbiological_process
GO:0048488synaptic vesicle endocytosisISSbiological_process
GO:0006644phospholipid metabolic processIEAbiological_process
GO:0071280cellular response to copper ionIDAbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIDAmolecular_function
GO:0051281positive regulation of release of sequestered calcIDAbiological_process
GO:0071902positive regulation of protein serine/threonine kiIDAbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0005791rough endoplasmic reticulumIEAcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0040012regulation of locomotionIEAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0014059regulation of dopamine secretionIEAbiological_process
GO:0050544arachidonic acid bindingIEAmolecular_function
GO:0019894kinesin bindingIPImolecular_function
GO:0042417dopamine metabolic processIEAbiological_process
GO:0032026response to magnesium ionIDAbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0055114oxidation-reduction processIDAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0030426growth coneIEAcellular_component
GO:0033138positive regulation of peptidyl-serine phosphorylaISSbiological_process
GO:0048489synaptic vesicle transportIEAbiological_process
GO:0051612negative regulation of serotonin uptakeIDAbiological_process
GO:0043274phospholipase bindingIEAmolecular_function
GO:0042775mitochondrial ATP synthesis coupled electron transIEAbiological_process
GO:0016491oxidoreductase activityIDAmolecular_function
GO:0010642negative regulation of platelet-derived growth facIDAbiological_process
GO:0043014alpha-tubulin bindingIPImolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0005509calcium ion bindingIDAmolecular_function
GO:0030054cell junctionIEAcellular_component
GO:0070555response to interleukin-1IDAbiological_process
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0050808synapse organizationIEAbiological_process
GO:0051585negative regulation of dopamine uptake involved inIDAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process