Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRS1_HUMAN
Description:insulin receptor substrate 1 [Source:HGNC Symbol;Acc:6125]
Location:chr2 q36.3
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S323GGKPGsFRVRAPhosphoSitePlus; phosphoELM
S636DYMPMsPKSVSErk2RegPhos
S272RSKSQsSSNCSIKK_groupphosphoELM; RegPhos
S345ASVDGsPVSPSIKKbRegPhos
S274KSQSSsNCSNPIKKbRegPhos
S99AIAADsEAEQDCK2_groupRegPhos
T859RLARPtRLSLGPhosphoSitePlus
Y941TGTEEyMKMDLPhosphoSitePlus; HPRD; RegPhos
Y941TGTEEyMKMDLINSRRegPhos
T305TRRSRtESITAPhosphoSitePlus
S268EFRPRsKSQSSPhosphoSitePlus
Y612HTDDGyMPMSPJAK1HPRD; RegPhos
S24LRKPKsMHKRFPLK1phosphoELM; RegPhos
S629SGRKGsGDYMPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y896KSPGEyVNIEFIGF1RHPRD; RegPhos
T351PVSPStNRTHAPhosphoSitePlus; HPRD
S270RPRSKsQSSSNIKKbRegPhos
S1041SSSAAsASPTGPhosphoSitePlus
S574PGHRHsAFVPTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S527RKRTHsAGTSPIKKbRegPhos
S307RSRTEsITATSPKCd(PKC deltaRegPhos
Y1179ENGLNyIDLDLPhosphoSitePlus; HPRD; RegPhos
S312SITATsPASMVMAPK8HPRD
S794LRLSTsSGRLLSIKphosphoELM; RegPhos
S794LRLSTsSGRLLSIK2HPRD
Y896KSPGEyVNIEFPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S307RSRTEsITATSPKC_deltaphosphoELM
S312SITATsPASMVMAPK_groupRegPhos
S736DYMNMsPVGDSHPRD; RegPhos
Y1179ENGLNyIDLDLINSRRegPhos
S1100CRRRHsSETFSPhosphoSitePlus; HPRD
Y896KSPGEyVNIEFINSRRegPhos
Y632KGSGDyMPMSPPhosphoSitePlus; phosphoELM; RegPhos
Y632KGSGDyMPMSPJAK1HPRD; RegPhos
S24LRKPKsMHKRFP67870(Casein kinase II )RegPhos
S1005SYVDTsPAAPVPhosphoSitePlus
S1101RRRHSsETFSSPRKCQHPRD; SysPTM
S1101RRRHSsETFSSPRKCDHPRD; SysPTM
S1101RRRHSsETFSSPRKCGHPRD; SysPTM
T811DSSSStSSDSLCSNK2BHPRD
S345ASVDGsPVSPSIKK_groupphosphoELM; RegPhos
S636DYMPMsPKSVSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S307RSRTEsITATSIKBKBHPRD
Y732PCTGDyMNMSPJAK1HPRD; RegPhos
S24LRKPKsMHKRFPHPhosphoSitePlus
T502GTGLGtSPALACSNK2A1HPRD
T88LVALYtRDEHFP67870(Casein kinase II )RegPhos
S270RPRSKsQSSSNIKK_groupphosphoELM; RegPhos
S527RKRTHsAGTSPIKBKBHPRD
S307RSRTEsITATSIKK_groupphosphoELM; RegPhos
S307RSRTEsITATSIKKbRegPhos
S1142DVKRHsSASFEPhosphoSitePlus
S616GYMPMsPGVAPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y612HTDDGyMPMSPINSRRegPhos
S350SPVSPsTNRTHPhosphoSitePlus
T1103RHSSEtFSSTPPhosphoSitePlus; HPRD; SysPTM
S892PPEPKsPGEYVPhosphoSitePlus; phosphoELM; RegPhos
S794LRLSTsSGRLLNuaK2RegPhos
S531HSAGTsPTITHIKBKBHPRD
S268EFRPRsKSQSSIKKbRegPhos
S341MSRPAsVDGSPIKK_groupphosphoELM; RegPhos
S668MMMSPsGGCSPPhosphoSitePlus
S315ATSPAsMVGGKPhosphoSitePlus
S348DGSPVsPSTNRPhosphoSitePlus; phosphoELM; RegPhos
T453DSLGHtPPARGPhosphoSitePlus
S312SITATsPASMVJNK1(MAPK8RegPhos
Y46PARLEyYENEKPHPhosphoSitePlus
Y1012AAPVSyADMRTPhosphoSitePlus
T446SFRSVtPDSLGPhosphoSitePlus
S341MSRPAsVDGSPPhosphoSitePlus
S330RVRASsDGEGTPhosphoSitePlus
T495NGHRCtPGTGLPhosphoSitePlus
S441CDFRSsFRSVTPhosphoSitePlus
S531HSAGTsPTITHPhosphoSitePlus; phosphoELM
S694VPSGTsYGKLWPhosphoSitePlus
S1143VKRHSsASFENPhosphoSitePlus; HPRD; SysPTM
S374LNHSRsIPMPAPhosphoSitePlus; phosphoELM; RegPhos
Y465EELSNyICMGGINSRRegPhos
S345ASVDGsPVSPSIKBKBHPRD
S463GEEELsNYICMPhosphoSitePlus
S345ASVDGsPVSPSRegPhos
S1078TRVNLsPNRNQPhosphoSitePlus; phosphoELM; RegPhos
S274KSQSSsNCSNPIKBKBHPRD
S531HSAGTsPTITHIKKbRegPhos
S312SITATsPASMVIKKbRegPhos
S636DYMPMsPKSVSMAPK1HPRD
S666GYMMMsPSGGCPhosphoSitePlus; HPRD; RegPhos
Y183NLIGIyRLCLTIRSPhosphoSitePlus
T88LVALYtRDEHFCSNK2BHPRD
T311ESITAtSPASMPhosphoSitePlus
S24LRKPKsMHKRFCSNK2BHPRD
S794LRLSTsSGRLLAMPK_groupphosphoELM
Y87HLVALyTRDEHPHPhosphoSitePlus
S303GLTRRsRTESIPhosphoSitePlus
S270RPRSKsQSSSNIKBKBHPRD
S531HSAGTsPTITHIKK_groupphosphoELM; RegPhos
S99AIAADsEAEQDP67870(Casein kinase II )RegPhos
S574PGHRHsAFVPTPKCd(PKC deltaRegPhos
S604HRPDSsTLHTDPhosphoSitePlus
S766VLSYYsLPRSFPhosphoSitePlus; HPRD
Y1229EDLSAyASISFHPRD; RegPhos
S527RKRTHsAGTSPIKK_groupphosphoELM; RegPhos
S486GHYILsRGGNGPhosphoSitePlus
S639PMSPKsVSAPQPhosphoSitePlus; phosphoELM; RegPhos
S616GYMPMsPGVAPErk1(MAPK3RegPhos
S312SITATsPASMVIKK_groupphosphoELM; RegPhos
S1043SAASAsPTGPQPhosphoSitePlus
S794LRLSTsSGRLLQIKRegPhos
Y47ARLEYyENEKKPHPhosphoSitePlus
S330RVRASsDGEGTCSNK2BHPRD
T938EEETGtEEYMKPhosphoSitePlus
S307RSRTEsITATSPhosphoSitePlus; phosphoELM
T309RTESItATSPAPhosphoSitePlus
S3PESDHPRD
Y632KGSGDyMPMSPINSRRegPhos
T811DSSSStSSDSLP67870(Casein kinase II )RegPhos
S1101RRRHSsETFSSPKC_thetaphosphoELM; SysPTM
S680IGGGPsSSSSSPhosphoSitePlus
S672PSGGCsPDIGGPhosphoSitePlus
S1109FSSTPsATRVGPhosphoSitePlus
S1223STRRSsEDLSAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y46PARLEyYENEKHPRD; phosphoELM; RegPhos
S1101RRRHSsETFSSPKCt(PKC thetaRegPhos; SysPTM
Y662VDPNGyMMMSPPhosphoSitePlus; phosphoELM; RegPhos
S270RPRSKsQSSSNPhosphoSitePlus
Y695PSGTSyGKLWTPhosphoSitePlus
S449SVTPDsLGHTPPhosphoSitePlus
Y483APNGHyILSRGPhosphoSitePlus
S272RSKSQsSSNCSIKBKBHPRD
S312SITATsPASMVIKBKBHPRD
S1101RRRHSsETFSSPKCdRegPhos; SysPTM
Y662VDPNGyMMMSPJAK1HPRD; RegPhos
S274KSQSSsNCSNPIKK_groupphosphoELM; RegPhos
T605RPDSStLHTDDPhosphoSitePlus
S372PPLNHsRSIPMPhosphoSitePlus
T502GTGLGtSPALACK2a1RegPhos
S24LRKPKsMHKRFCK2_groupphosphoELM; RegPhos
S268EFRPRsKSQSSIKK_groupphosphoELM; RegPhos
Y465EELSNyICMGGPhosphoSitePlus
T1111STPSAtRVGNTPhosphoSitePlus; phosphoELM
T1107ETFSStPSATRPhosphoSitePlus
Y612HTDDGyMPMSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S330RVRASsDGEGTP67870(Casein kinase II )RegPhos
T936PREEEtGTEEYPhosphoSitePlus
S341MSRPAsVDGSPIKKbRegPhos
S362HRHRGsARLHPPhosphoSitePlus
T608SSTLHtDDGYMPhosphoSitePlus
S99AIAADsEAEQDCSNK2BHPRD
S1101RRRHSsETFSSPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S3MASPPeSDRegPhos
S329FRVRAsSDGEGPhosphoSitePlus; RegPhos
Y989SSRGDyMTMQMPhosphoSitePlus
T847PRKVDtAAQTNPhosphoSitePlus
S1145RHSSAsFENVWPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T502GTGLGtSPALACK2a1-rsRegPhos
S312SITATsPASMVPhosphoSitePlus; phosphoELM; RegPhos
S312SITATsPASMVJNK1RegPhos
S341MSRPAsVDGSPIKBKBHPRD
S1101RRRHSsETFSSPKCtRegPhos; SysPTM
S1101RRRHSsETFSSPKCgRegPhos; SysPTM
S527RKRTHsAGTSPPhosphoSitePlus
S1101RRRHSsETFSSRSK-1phosphoELM; SysPTM
S1222SSTRRsSEDLSPhosphoSitePlus; phosphoELM; RegPhos
S616GYMPMsPGVAPErk2RegPhos
S794LRLSTsSGRLLPhosphoSitePlus; HPRD; RegPhos
S603HHRPDsSTLHTPhosphoSitePlus
Y989SSRGDyMTMQMINSRRegPhos
Y732PCTGDyMNMSPPhosphoSitePlus
Y1229EDLSAyASISFINSRRegPhos
S273SKSQSsSNCSNPhosphoSitePlus
T530THSAGtSPTITPhosphoSitePlus; phosphoELM; RegPhos
S272RSKSQsSSNCSIKKbRegPhos
S323GGKPGsFRVRAPKCz(PKC zetaRegPhos
Y87HLVALyTRDEHHPRD
S616GYMPMsPGVAPMAPK1HPRD
S616GYMPMsPGVAPMAPK3phosphoELM
S574PGHRHsAFVPTPKC_deltaphosphoELM
S268EFRPRsKSQSSIKBKBHPRD
S323GGKPGsFRVRAPKC_zetaphosphoELM
S274KSQSSsNCSNPPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1179GLENGLNyIDLDLVKPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000304895A849SCOSMICLung Cancer20668451
ENSP00000304895E147DDing2008, COSMICLung Cancer18948947
ENSP00000304895R1140HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000304895G529DCOSMICOvarian Cancer20668451
ENSP00000304895P679LCOSMICPancreatic Cancer21252315
ENSP00000304895G677DCOSMICLung Cancer20668451
ENSP00000304895H287NBIOMARTBreast Cancer21930507, 21930502
ENSP00000304895D1003HDing2008, COSMICLung Cancer18948947
ENSP00000304895V154LDing2008, COSMICLung Cancer18948947
ENSP00000304895G1154VCOSMICOvarian Cancer21720365
ENSP00000304895D731GCOSMICOvarian Cancer21720365
ENSP00000304895S428LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000304895Y47CCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
IRS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S636SGDYMPMsPKSVSAPtype 2 diabetes12765939PhosphoSitePlus
S1101GCRRRHSsETFSSTPtype 2 diabetes17709744PhosphoSitePlus
Y612TLHTDDGyMPMSPGVcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
SIK2_HUMANIRS1_HUMANkinase -> substrateHPRD; RegPhos
KPCG_HUMANIRS1_HUMANkinase -> substrateHPRD
IGF1R_HUMANIRS1_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANIRS1_HUMANkinase -> substrateRegPhos
MK03_HUMANIRS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANIRS1_HUMANkinase -> substrateRobert H Newman (2013)
FES_HUMANIRS1_HUMANkinase -> substrateNetPath
KS6B1_HUMANIRS1_HUMANkinase -> substrateKEGG; NetPath
IKKA_HUMANIRS1_HUMANkinase -> substrateKEGG
MK08_HUMANIRS1_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
JAK1_HUMANIRS1_HUMANkinase -> substrateNetPath
MK01_HUMANIRS1_HUMANkinase -> substrateHPRD
CSK21_HUMANIRS1_HUMANkinase -> substrateHPRD
CSK2B_HUMANIRS1_HUMANkinase -> substrateHPRD
KPCD_HUMANIRS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCT_HUMANIRS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
SIK1_HUMANIRS1_HUMANkinase -> substrateRegPhos
PLK1_HUMANIRS1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
IKKB_HUMANIRS1_HUMANkinase -> substrateKEGG; HPRD
ZAGL2_HUMANIRS1_HUMANkinase -> substrateRegPhos
JAK3_HUMANIRS1_HUMANkinase -> substrateNetPath
PTPRF_HUMANIRS1_HUMANphosphatase -> substrateKEGG
PTN1_HUMANIRS1_HUMANphosphatase -> substrateKEGG
PTN11_HUMANIRS1_HUMANphosphatase -> substrateHPRD
IRS1_HUMANPI3R5_HUMANotherKEGG
SOCS3_HUMANIRS1_HUMANotherKEGG
MTOR_HUMANIRS1_HUMANotherKEGG
IRS1_HUMANGRB2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04930Type II diabetes mellitus
hsa04722Neurotrophin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008286insulin receptor signaling pathwayIDAbiological_process
GO:0046326positive regulation of glucose importIMPbiological_process
GO:0032868response to insulin stimulusIDAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0010468regulation of gene expressionIEAbiological_process
GO:0005159insulin-like growth factor receptor bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0042593glucose homeostasisTASbiological_process
GO:0016042lipid catabolic processIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0045725positive regulation of glycogen biosynthetic proceIMPbiological_process
GO:0046627negative regulation of insulin receptor signaling ISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0043231intracellular membrane-bounded organelleISScellular_component
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0034504protein localization to nucleusIEAbiological_process
GO:0005899insulin receptor complexISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0043434response to peptide hormone stimulusISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0008284positive regulation of cell proliferationNASbiological_process
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIPIbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005068transmembrane receptor protein tyrosine kinase adaISSmolecular_function
GO:0005901caveolaIDAcellular_component
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusISScellular_component
GO:0042169SH2 domain bindingISSmolecular_function
GO:0046676negative regulation of insulin secretionIDAbiological_process
GO:0046628positive regulation of insulin receptor signaling ISSbiological_process
GO:2001275positive regulation of glucose import in response IDAbiological_process
GO:0032000positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingISSmolecular_function
GO:0010907positive regulation of glucose metabolic processIMPbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0005158insulin receptor bindingIPImolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0005080protein kinase C bindingISSmolecular_function
GO:0014065phosphatidylinositol 3-kinase cascadeIDAbiological_process