Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOP2A_HUMAN
Description:topoisomerase (DNA) II alpha 170kDa [Source:HGNC Symbol;Acc:11989]
Location:chr17 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1361PKTKTsPKLSNPhosphoSitePlus
S1361PKTKTsPKLSNCDC2(CDK1RegPhos
Y518IVGLQyKKNYEToprimPhosphoSitePlus
S1337SDEDFsDFDEKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1213AEVLPsPRGQRErk1(MAPK3RegPhos
S1377QKSVVsDLEADCK2a1(CK2 alphaRegPhos
S1106EENEEsDNEKEDNA_topoisoIVPhosphoSitePlus
S1247ENTEGsPQEDGMAPK1phosphoELM
S1452LNSGVsQKPDPDTHCTPhosphoSitePlus
S1303ESDRSsDESNFPhosphoSitePlus; HPRD
S1393VPLSSsPPATHErk1(MAPK3RegPhos
S1354VPSDAsPPKTKMAPK3phosphoELM
S1469RKRKPsTSDDSCK2a1-rsRegPhos
S1247ENTEGsPQEDGCDC2RegPhos
T1324RAATKtKFTMDPhosphoSitePlus
S1393VPLSSsPPATHCDC2RegPhos
S1374LKPQKsVVSDLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1525KYLEEsDEDDLCK2a1-rsRegPhos
S1297NPWSDsESDRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1469RKRKPsTSDDSCK2a1RegPhos
S717ERSIPsMVDGLDNA_topoisoIVPhosphoSitePlus
T1244IKNENtEGSPQPhosphoSitePlus; HPRD; phosphoELM
S29AKKRLsVERIYPRKCAHPRD
S1449DPALNsGVSQKHPRD; phosphoELM
S1302SESDRsSDESNPhosphoSitePlus; HPRD
S1495KSKGEsDDFHMHPRD; phosphoELM
S1469RKRKPsTSDDSCK2_groupRegPhos
S1525KYLEEsDEDDCK2_groupphosphoELM
S1474STSDDsDSNFEHPRD; phosphoELM; RegPhos
T1343DFDEKtDDEDFCK2_groupphosphoELM; RegPhos
T1343DFDEKtDDEDFCSNK2A1HPRD
S1361PKTKTsPKLSNCDK1HPRD; phosphoELM
Y328GRHVDyVADQIDNA_gyraseBPhosphoSitePlus
S714SDNERsIPSMVDNA_topoisoIVPhosphoSitePlus
S1495KSKGEsDDFHMDTHCTPhosphoSitePlus
T250DIAGStKDVKVPhosphoSitePlus
S1354VPSDAsPPKTKErk1(MAPK3RegPhos
S1392SVPLSsSPPATPhosphoSitePlus; HPRD; phosphoELM
S707ELILFsNSDNEHPRD
S1525KYLEEsDEDDCK2_alphaphosphoELM
S1469RKRKPsTSDDSCSNK2A1HPRD
S1476SDDSDsNFEKIHPRD
S1393VPLSSsPPATHMAPK1phosphoELM
S1393VPLSSsPPATHMAPK3phosphoELM
T1403HFPDEtEITNPPhosphoSitePlus; HPRD
S1213AEVLPsPRGQRMAPK3phosphoELM
S1164KRKSPsDLWKEHPRD
T282DKLDEtGNSLKHPRD
S29AKKRLsVERIYPRKCGHPRD
S1295KRNPWsDSESDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1521KKPIKyLEESDDTHCTPhosphoSitePlus
S1354VPSDAsPPKTKCDK1HPRD; phosphoELM
S1387DDVKGsVPLSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1117TEKSDsVTDSGHPRD
S1306RSSDEsNFDVPHPRD
S1213AEVLPsPRGQRMAPK1phosphoELM
S1213AEVLPsPRGQRCDK1HPRD; phosphoELM
T1205AKGKKtQMAEVPhosphoSitePlus; HPRD
S1247ENTEGsPQEDGCDC2(CDK1RegPhos
T1397SSPPAtHFPDEPhosphoSitePlus; HPRD; phosphoELM
S1393VPLSSsPPATHCDK1HPRD; phosphoELM
S1377QKSVVsDLEADCSNK2A1HPRD
S1361PKTKTsPKLSNErk1(MAPK3RegPhos
S1213AEVLPsPRGQRCDC2(CDK1RegPhos
S1491VTSKKsKGESDHPRD; phosphoELM
S1452LNSGVsQKPDPHPRD; phosphoELM
T1360PPKTKtSPKLSHPRD
S1393VPLSSsPPATHErk2(MAPK1RegPhos
T1274EPGTKtKKQTTPhosphoSitePlus
S1504HMDFDsAVAPRHPRD; phosphoELM
S1491VTSKKsKGESDDTHCTPhosphoSitePlus
S1471RKPSTsDDSDSHPRD; phosphoELM; RegPhos
S1361PKTKTsPKLSNErk2(MAPK1RegPhos
S29AKKRLsVERIYPhosphoSitePlus; phosphoELM; RegPhos
S1525KYLEEsDEDDCSNK2A1HPRD
S1361PKTKTsPKLSNMAPK3phosphoELM
S1426AKSQSsTSTTGPhosphoSitePlus
S1213AEVLPsPRGQRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1247ENTEGsPQEDGErk2(MAPK1RegPhos
S1106EENEEsDNEKEHPRD; phosphoELM; RegPhos
S1354VPSDAsPPKTKErk2(MAPK1RegPhos
S1525KYLEEsDEDDHPRD; phosphoELM
S230KFKMQsLDKDIPhosphoSitePlus; HPRD
T1343DFDEKtDDEDFPKCb(PKC betaRegPhos
S1365TSPKLsNKELKPhosphoSitePlus; HPRD
T1343DFDEKtDDEDFCK2a1-rsRegPhos
S1469RKRKPsTSDDSDTHCTPhosphoSitePlus
T1343DFDEKtDDEDFCK2a1RegPhos
T1358ASPPKtKTSPKHPRD; phosphoELM
Y82FVPGLyKIFDEHATPase_cPhosphoSitePlus
S1377QKSVVsDLEADPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S4MEVSPlQPVRegPhos
S1354VPSDAsPPKTKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1393VPLSSsPPATHCDC2(CDK1RegPhos
S1377QKSVVsDLEADCK2_alphaphosphoELM
T282DKLDEtGNSLKDNA_gyraseBPhosphoSitePlus
S1377QKSVVsDLEADCK2a1-rsRegPhos
S1377QKSVVsDLEADCK2a1RegPhos
S1449DPALNsGVSQKDTHCTPhosphoSitePlus
S1504HMDFDsAVAPRDTHCTPhosphoSitePlus
S285DETGNsLKVIHHPRD
S29AKKRLsVERIYPKCbRegPhos
S1332TMDLDsDEDFSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1521KKPIKyLEESDHPRD
S249YDIAGsTKDVKPhosphoSitePlus
T1470KRKPStSDDSDHPRD; phosphoELM; RegPhos
S1354VPSDAsPPKTKCDC2RegPhos
T1429QSSTStTGAKKPhosphoSitePlus
Y805SASPRyIFTMLDNA_topoisoIVPhosphoSitePlus
S1393VPLSSsPPATHPhosphoSitePlus; phosphoELM; RegPhos
S1247ENTEGsPQEDGErk1(MAPK3RegPhos
S1525KYLEEsDEDDLCK2a1RegPhos
S29AKKRLsVERIYPKC_groupphosphoELM; RegPhos
S4__MEVsPLQPVPhosphoSitePlus
S1213AEVLPsPRGQRErk2(MAPK1RegPhos
S1377QKSVVsDLEADCK2_groupphosphoELM; RegPhos
S1213AEVLPsPRGQRCDC2RegPhos
S1361PKTKTsPKLSNMAPK1phosphoELM
S1162TLKRKsPSDLWHPRD
S1247ENTEGsPQEDGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1469RKRKPsTSDDSHPRD; phosphoELM; RegPhos
S1299WSDSEsDRSSDPhosphoSitePlus; HPRD
T1343DFDEKtDDEDFPhosphoSitePlus; phosphoELM; RegPhos
Y830TLKFLyDDNQRDNA_topoisoIVPhosphoSitePlus
S4LQPVHPRD; phosphoELM
T1327TKTKFtMDLDSPhosphoSitePlus; HPRD; phosphoELM
T1343DFDEKtDDEDFPKC_betaphosphoELM
S1471RKPSTsDDSDSDTHCTPhosphoSitePlus
T1119KSDSVtDSGPTDNA_topoisoIVPhosphoSitePlus
S29AKKRLsVERIYPKCaRegPhos
S29AKKRLsVERIYPKCgRegPhos
T1470KRKPStSDDSDDTHCTPhosphoSitePlus
S1115KETEKsDSVTDHPRD
S1525KYLEEsDEDDLCK2_groupRegPhos
S1391GSVPLsSSPPAPhosphoSitePlus; HPRD; phosphoELM
S1247ENTEGsPQEDGCDK1HPRD; phosphoELM
S1474STSDDsDSNFEDTHCTPhosphoSitePlus
S1354VPSDAsPPKTKMAPK1phosphoELM
S1525KYLEEsDEDDLCK2a1(CK2 alphaRegPhos
S1476SDDSDsNFEKIDTHCTPhosphoSitePlus
S285DETGNsLKVIHDNA_gyraseBPhosphoSitePlus
S1525KYLEEsDEDDLPhosphoSitePlus; RegPhos
S1247ENTEGsPQEDGMAPK3phosphoELM
S1354VPSDAsPPKTKCDC2(CDK1RegPhos
S1351EDFVPsDASPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1430SSTSTtGAKKRPhosphoSitePlus
S1361PKTKTsPKLSNCDC2RegPhos
T898KNFKGtIEELADNA_topoisoIVPhosphoSitePlus
S29AKKRLsVERIYPRKCBHPRD

Dephosphorylation site
TOP2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000411532V913ICOSMICOvarian Cancer21720365
ENSP00000411532V255ICOSMICMelanoma
ENSP00000411532Q355ECOSMICOvarian Cancer21720365
ENSP00000411532L1166FCOSMICOvarian Cancer21720365
ENSP00000411532D1473YCOSMICOvarian Cancer21720365
ENSP00000411532E1109KCOSMICHead and Neck Cancer21798893
ENSP00000411532D1017HBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
TOP2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TOP2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANTOP2A_HUMANkinase -> substrateRegPhos
CSK21_HUMANTOP2A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCB_HUMANTOP2A_HUMANkinase -> substrateHPRD
MK01_HUMANTOP2A_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANTOP2A_HUMANkinase -> substrateHPRD
ZAGL2_HUMANTOP2A_HUMANkinase -> substrateRegPhos
KPCG_HUMANTOP2A_HUMANkinase -> substrateHPRD
MK03_HUMANTOP2A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TOP2A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0070683mitotic cell cycle G2/M transition decatenation chIBAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0008144drug bindingIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006261DNA-dependent DNA replicationIBAbiological_process
GO:0030261chromosome condensationIEAbiological_process
GO:0000712resolution of meiotic recombination intermediatesIBAbiological_process
GO:0030263apoptotic chromosome condensationIDAbiological_process
GO:0000795synaptonemal complexIBAcellular_component
GO:0003682chromatin bindingIDAmolecular_function
GO:0005654nucleoplasmIDAcellular_component
GO:0040016embryonic cleavageIEAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0006266DNA ligationIDAbiological_process
GO:0000228nuclear chromosomeIDAcellular_component
GO:0043130ubiquitin bindingIMPmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0009330DNA topoisomerase complex (ATP-hydrolyzing)IDAcellular_component
GO:0005694chromosomeIEAcellular_component
GO:0000819sister chromatid segregationIBAbiological_process
GO:0043234protein complexIPIcellular_component
GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activiIEAmolecular_function
GO:0006281DNA repairNASbiological_process
GO:0045070positive regulation of viral genome replicationIMPbiological_process
GO:0005814centrioleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007059chromosome segregationIEAbiological_process
GO:0005080protein kinase C bindingIPImolecular_function
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0006260DNA replicationNASbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0045870positive regulation of retroviral genome replicatiIMPbiological_process
GO:0000793condensed chromosomeIEAcellular_component
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0019035viral integration complexNAScellular_component
GO:0008301DNA binding, bendingIDAmolecular_function
GO:0006265DNA topological changeIEAbiological_process
GO:0006312mitotic recombinationIBAbiological_process
GO:0005730nucleolusIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process


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