Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PSA3_HUMAN
Description:proteasome (prosome, macropain) subunit, alpha type, 3 [Source:HGNC Symbol;Acc:9532]
Location:chr14 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S243KYAKEsLKEEDCK2_groupphosphoELM; RegPhos
S243KEEDEsDDDHPRD
S250KEEDEsDDDHPRD; phosphoELM; SysPTM
Y154GVSYGyWGCAIHPRD
Y161GVSYGyWGCAIProteasomePhosphoSitePlus
T186QMKEMtCRDIVProteasomePhosphoSitePlus
Y105RSNFGyNIPLKProteasomePhosphoSitePlus
Y8SIGTGyDLSASPhosphoSitePlus; HPRD
S250KEEDEsDDDNMPhosphoSitePlus; RegPhos; SysPTM
S243KYAKEsLKEEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S236KYAKEsLKEEDHPRD
S97AREEAsNFRSNProteasomePhosphoSitePlus
S16SASTFsPDGRVPhosphoSitePlus; HPRD
S243KYAKEsLKEEDCSNK2A1HPRD
S250KEEDEsDDDCK2_groupphosphoELM; SysPTM
S250KEEDEsDDDNMCK2_groupRegPhos; SysPTM
S243KYAKEsLKEEDCK2a1-rsRegPhos
Y161GVSYGyWGCAIHPRD; RegPhos
S243KYAKEsLKEEDCK2a1RegPhos

Dephosphorylation site
PSA3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216455E178QBIOMARTBreast Cancer21930507, 21930502
ENSP00000390491E171QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000216455Thyroid CarcinomaNormal vs. CancertissueUp2.617194741
ENSP00000216455Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.416807943

Hyperphosphorylation site
PSA3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANPSA3_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPSA3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03050Proteasome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044281small molecule metabolic processTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0000502proteasome complexTAScellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0051603proteolysis involved in cellular protein catabolicIEAbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0006521regulation of cellular amino acid metabolic procesTASbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0019773proteasome core complex, alpha-subunit complexIEAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0005839proteasome core complexIDAcellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0005839proteasome core complexIEAcellular_component
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0004298threonine-type endopeptidase activityIEAmolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0004175endopeptidase activityIEAmolecular_function
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0002479antigen processing and presentation of exogenous pTASbiological_process


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