| UniProt/SwissProt ID: | HMOX2_HUMAN |
| Description: | heme oxygenase (decycling) 2 [Source:HGNC Symbol;Acc:5014] |
| Location: | chr16 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T286 | SCPFRtAMAVL | PhosphoSitePlus | |
| S79 | LYFTYsALEEE | CSNK2A1 | HPRD |
| Y157 | HAYTRyMGDLS | Heme_oxygenase | PhosphoSitePlus |
| Y202 | QFKQLyRARMN | Heme_oxygenase | PhosphoSitePlus |
| Dephosphorylation site |
| HMOX2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000219700 | R205S | COSMIC | Skin Cancer | 21984974 | ENSP00000219700 | D112N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| HMOX2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HMOX2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | HMOX2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04978 | Mineral absorption |
| hsa00860 | Porphyrin and chlorophyll metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0006879 | cellular iron ion homeostasis | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0006979 | response to oxidative stress | IEA | biological_process |
| GO:0006778 | porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0001666 | response to hypoxia | IDA | biological_process |
| GO:0004392 | heme oxygenase (decyclizing) activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042167 | heme catabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006788 | heme oxidation | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0055085 | transmembrane transport | TAS | biological_process |