| UniProt/SwissProt ID: | HES6_HUMAN |
| Description: | hairy and enhancer of split 6 (Drosophila) [Source:HGNC Symbol;Acc:18254] |
| Location: | chr2 q37.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S183 | GDDLCsDLEEA | PhosphoSitePlus | |
| S183 | GDDLCsDLEEA | CSNK2A1 | HPRD |
| Dephosphorylation site |
| HES6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000272937 | P162S | COSMIC | Melanoma | |
| Differential expressed protein |
| HES6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HES6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | HES6_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| HES6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0003712 | transcription cofactor activity | IEA | molecular_function |
| GO:0005667 | transcription factor complex | ISS | cellular_component |
| GO:0008134 | transcription factor binding | NAS | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0003712 | transcription cofactor activity | ISS | molecular_function |