Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EGR1_HUMAN
Description:early growth response 1 [Source:HGNC Symbol;Acc:3238]
Location:chr5 q31.2
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T526SFSAStGLSDMCSNK2A1HPRD
T389TTHIRtHTGEKzf-UBR; zf-H2C2_2; RRN7PhosphoSitePlus
T526SFSAStGLSDMCK2a1RegPhos
S378CMRNFsRSDHLzf-H2C2_2; zf-UBRPhosphoSitePlus
S12EMQLMsPLQISPhosphoSitePlus
S196SCAVPsNDSSPDUF3446PhosphoSitePlus
T391HIRTHtGEKPFCK2a1RegPhos
S104HLTAEsFPDISPhosphoSitePlus
S26GSFPHsPTMDNPhosphoSitePlus
T148PNSGNtLWPEPDUF3446PhosphoSitePlus
T391HIRTHtGEKPFCSNK2A1HPRD
S378CMRNFsRSDHLCSNK2A1HPRD
T391HIRTHtGEKPFzf-UBR; zf-H2C2_2; RRN7PhosphoSitePlus
T526SFSAStGLSDMCK2a1-rsRegPhos
S378CMRNFsRSDHLCK2a1RegPhos
S301ATQSGsQDLKAPhosphoSitePlus
T391HIRTHtGEKPFCK2a1-rsRegPhos
S378CMRNFsRSDHLCK2a1-rsRegPhos
S378CMRNFsRSDHLCK2_groupphosphoELM; RegPhos

Dephosphorylation site
EGR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000239938T384ABIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000239938R320HCOSMICOvarian Cancer21720365
ENSP00000239938R320HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
EGR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EGR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANEGR1_HUMANkinase -> substrateHPRD
FLI1_HUMANEGR1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANTNFL6_HUMANTF -> target geneTRANSFAC
EGR1_HUMANELK1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANRET_HUMANTF -> target geneTRANSFAC
EGR1_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANEGR1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANEGFR_HUMANTF -> target geneTRANSFAC
EGR1_HUMANTNFA_HUMANTF -> target geneTRANSFAC
EGR1_HUMANIL2_HUMANTF -> target geneTRANSFAC
SRF_HUMANEGR1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANAOFB_HUMANTF -> target geneTRANSFAC
ATF1_HUMANEGR1_HUMANTF -> target geneTRANSFAC
EGR1_HUMANTGFR2_HUMANTF -> target geneTRANSFAC
EGR1_HUMANIL3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05020Prion diseases
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007623circadian rhythmIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0071506cellular response to mycophenolic acidIEAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0031667response to nutrient levelsIEAbiological_process
GO:0072110glomerular mesangial cell proliferationISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0071371cellular response to gonadotropin stimulusIEAbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0033233regulation of protein sumoylationIDAbiological_process
GO:0071873response to norepinephrine stimulusIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0071236cellular response to antibioticIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0010942positive regulation of cell deathIEAbiological_process
GO:0071455cellular response to hyperoxiaIEAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0000982RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0051602response to electrical stimulusIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0071504cellular response to heparinISSbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0071506cellular response to mycophenolic acidISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0071317cellular response to isoquinoline alkaloidIEAbiological_process
GO:0071480cellular response to gamma radiationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0034465response to carbon monoxideIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0071320cellular response to cAMPIEAbiological_process
GO:0035690cellular response to drugIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0000976transcription regulatory region sequence-specific IDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0071383cellular response to steroid hormone stimulusIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0045471response to ethanolIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0071372cellular response to follicle-stimulating hormone IEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0035035histone acetyltransferase bindingIPImolecular_function
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0072110glomerular mesangial cell proliferationIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0034698response to gonadotropin stimulusIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0032354response to follicle-stimulating hormone stimulusIEAbiological_process
GO:0072303positive regulation of glomerular metanephric mesaIEAbiological_process
GO:0072303positive regulation of glomerular metanephric mesaISSbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0071504cellular response to heparinIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function