| UniProt/SwissProt ID: | G6PI_HUMAN |
| Description: | glucose-6-phosphate isomerase [Source:HGNC Symbol;Acc:4458] |
| Location: | chr19 q13.11 |
| Node attribute: | ligand; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S185 | RVWYVsNIDGT | CK2a1-rs | RegPhos |
| T251 | LSTNTtKVKEF | PGI | PhosphoSitePlus |
| S185 | RVWYVsNIDGT | CK2a1 | RegPhos |
| S247 | HFVALsTNTTK | PGI | PhosphoSitePlus |
| Y174 | EALKPySSGGP | PGI | PhosphoSitePlus |
| S185 | RVWYVsNIDGT | CSNK2A1 | HPRD |
| T250 | ALSTNtTKVKE | PGI | PhosphoSitePlus |
| T61 | SKNLVtEDVMR | PGI | PhosphoSitePlus |
| S185 | RVWYVsNIDGT | CK2_group | phosphoELM; RegPhos |
| S441 | LMRGKsTEEAR | PGI | PhosphoSitePlus |
| Y92 | GEKINyTEGRA | PGI | PhosphoSitePlus |
| T109 | RNRSNtPILVD | PGI | PhosphoSitePlus; SysPTM |
| T248 | FVALStNTTKV | PGI | PhosphoSitePlus |
| Y183 | GPRVWyVSNID | PGI | PhosphoSitePlus |
| S107 | ALRNRsNTPIL | PGI | PhosphoSitePlus |
| S185 | RVWYVsNIDGT | PGI | PhosphoSitePlus |
| Y17 | KLQQWyREHRS | PhosphoSitePlus | |
| T93 | EKINYtEGRAV | PGI | PhosphoSitePlus |
| T412 | LIPVQtQHPIR | PGI | PhosphoSitePlus |
| T215 | SKTFTtQETIT | PGI | PhosphoSitePlus |
| T109 | RNRSNtPILVD | HPRD; SysPTM | |
| T214 | ASKTFtTQETI | PGI | PhosphoSitePlus |
| Dephosphorylation site |
| G6PI_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000348877 | S367C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000348877 | S367C | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000348877 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.3 | 18715028 | ENSP00000348877 | Prostate Cancer | Metastasis | cell line | Down | 0.34 | 15102926 | ENSP00000348877 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Up | 2 | 18491314 | ENSP00000348877 | Lung Cancer | Treatment(none vs 20 mg/mL GTE treatment) | cell line | Up | 8.7 | 19137550 | ENSP00000348877 | Lung Cancer | Treatment(none vs 40 mg/mL GTE treatment) | cell line | Up | 4.2 | 19137550 | ENSP00000348877 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.1 | 20804217 | ENSP00000348877 | Breast Cancer | Normal vs. Cancer | cell line | Up | 5.8 | 20198662 | ENSP00000348877 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Down | 0.61 | 20625496 |
| Hyperphosphorylation site |
| G6PI_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| G6PI_HUMAN | AMFR_HUMAN | ligand -> receptor | HPMR |
| CSK21_HUMAN | G6PI_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00520 | Amino sugar and nucleotide sugar metabolism |
| hsa00010 | Glycolysis / Gluconeogenesis |
| hsa00500 | Starch and sucrose metabolism |
| hsa01100 | Metabolic pathways |
| hsa00030 | Pentose phosphate pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0005975 | carbohydrate metabolic process | IEA | biological_process |
| GO:0016866 | intramolecular transferase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0006094 | gluconeogenesis | IEA | biological_process |
| GO:0048029 | monosaccharide binding | IEA | molecular_function |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0007611 | learning or memory | IEA | biological_process |
| GO:0019242 | methylglyoxal biosynthetic process | IEA | biological_process |
| GO:0043524 | negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007599 | hemostasis | TAS | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0006959 | humoral immune response | TAS | biological_process |
| GO:0051156 | glucose 6-phosphate metabolic process | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006096 | glycolysis | IEA | biological_process |
| GO:0004347 | glucose-6-phosphate isomerase activity | IEA | molecular_function |
| GO:0046185 | aldehyde catabolic process | IEA | biological_process |
| GO:0006006 | glucose metabolic process | TAS | biological_process |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0043154 | negative regulation of cysteine-type endopeptidase | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0001525 | angiogenesis | IEA | biological_process |