Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTN1_HUMAN
Description:protein tyrosine phosphatase, non-receptor type 1 [Source:HGNC Symbol;Acc:9642]
Location:chr20 q13.13
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y66QEDNDyINASLEGFRHPRD; phosphoELM; RegPhos
S50RYRDVsPFDHSPKB_groupphosphoELM; SysPTM
Y66QEDNDyINASLphosphoELM
S378RVVGGsLRGAQCK2a2RegPhos
Y152EDIKSyYTVRQINSRHPRD; phosphoELM; RegPhos
S50RYRDVsPFDHSAKT1HPRD; RegPhos; SysPTM
S352KEEKGsPLNAACK2a1RegPhos; SysPTM
S352KEEKGsPLNAACK2a1-rsRegPhos; SysPTM
S55SPFDHsRIKLHY_phosphatasePhosphoSitePlus
S352KEEKGsPLNAAPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S295QWKELsHEDLEPhosphoSitePlus; HPRD; RegPhos; SysPTM
Y66QEDNDyINASLINSRHPRD; RegPhos
S365GIESMsQDTEVPhosphoSitePlus
S386GAQAAsPAKGECDC2(CDK1RegPhos
S50RYRDVsPFDHSAKT1(PKBRegPhos; SysPTM
Y152EDIKSyYTVRQInsRRegPhos
S386GAQAAsPAKGECDK1HPRD; phosphoELM
S386GAQAAsPAKGECSNK2A2HPRD
Y153DIKSYyTVRQLINSRHPRD; phosphoELM; RegPhos
S386GAQAAsPAKGEPhosphoSitePlus
S243RKDPSsVDIKKCLK2HPRD; RegPhos
S243RKDPSsVDIKKCLK1HPRD; RegPhos
S50RYRDVsPFDHSY_phosphatasePhosphoSitePlus; SysPTM
Y271QLRFSyLAVIEY_phosphatasePhosphoSitePlus
S352KEEKGsPLNAACSNK2A2HPRD; SysPTM
S352KEEKGsPLNAACSNK2A1HPRD; SysPTM
S378RVVGGsLRGAQPKC_groupphosphoELM; RegPhos
S393AKGEPsLPEKDRegPhos
S378RVVGGsLRGAQCSNK2A2HPRD
S378RVVGGsLRGAQCSNK2A1HPRD
S378RVVGGsLRGAQPKCa(PKC alphaRegPhos
Y153DIKSYyTVRQLY_phosphatasePhosphoSitePlus
S242KRKDPsSVDIKCLK2HPRD; RegPhos
S242KRKDPsSVDIKCLK1HPRD; RegPhos
S352KEEKGsPLNAACK2a2RegPhos; SysPTM
Y66QEDNDyINASLInsRRegPhos
S378RVVGGsLRGAQCK2a1RegPhos
S386GAQAAsPAKGECK2a1-rsRegPhos
S50RYRDVsPFDHSCLK1HPRD; phosphoELM; RegPhos; SysPTM
S50RYRDVsPFDHSCLK2HPRD; RegPhos; SysPTM
S378RVVGGsLRGAQPKC_alphaphosphoELM
S242KRKDPsSVDIKY_phosphatasePhosphoSitePlus
Y152EDIKSyYTVRQY_phosphatasePhosphoSitePlus
Y66QEDNDyINASLY_phosphatasePhosphoSitePlus
Y153DIKSYyTVRQLInsRRegPhos
S386GAQAAsPAKGECK2a1RegPhos
S118VMEKGsLKCAQY_phosphatasePhosphoSitePlus
S50RYRDVsPFDHSAKT_groupRegPhos; SysPTM
S386GAQAAsPAKGECSNK2A1HPRD
S386GAQAAsPAKGECDC2RegPhos
S386GAQAAsPAKGECK2a2RegPhos
Y359LNAAPyGIESMPhosphoSitePlus
S386GAQAAsPAKGECDK_groupphosphoELM; RegPhos
S378RVVGGsLRGAQCK2a1-rsRegPhos
S378RVVGGsLRGAQPhosphoSitePlus
S243RKDPSsVDIKKY_phosphatasePhosphoSitePlus
Y46KNRNRyRDVSPY_phosphatasePhosphoSitePlus
Y20SWAAIyQDIRHPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
PTN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360683E300KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000360683Breast CancerNormal vs. CancertissueUp0.4420739354
ENSP00000360683Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PTN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EGFR_HUMANPTN1_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANPTN1_HUMANkinase -> substrateHPRD
CLK1_HUMANPTN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
INSR_HUMANPTN1_HUMANkinase -> substrateRegPhos
AKT1_HUMANPTN1_HUMANkinase -> substrateHPRD; RegPhos
CDK1_HUMANPTN1_HUMANkinase -> substrateHPRD; RegPhos
CSK22_HUMANPTN1_HUMANkinase -> substrateHPRD
KPCA_HUMANPTN1_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANPTN1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANPTN1_HUMANkinase -> substrateRegPhos
PTN1_HUMANESR1_HUMANphosphatase -> substrateHPRD
PTN1_HUMANBCR_HUMANphosphatase -> substrateHPRD
PTN1_HUMANSTA5B_HUMANphosphatase -> substrateHPRD
PTN1_HUMANINSR_HUMANphosphatase -> substrateHPRD; KEGG
PTN1_HUMANPGFRB_HUMANphosphatase -> substrateHPRD
PTN1_HUMANIRS1_HUMANphosphatase -> substrateKEGG
PTN1_HUMANSTA5A_HUMANphosphatase -> substrateHPRD
PTN1_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTN1_HUMANACTN1_HUMANphosphatase -> substrateHPRD
PTN1_HUMANMK01_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046627negative regulation of insulin receptor signaling NASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseIDAbiological_process
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046626regulation of insulin receptor signaling pathwayIEAbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0005769early endosomeIDAcellular_component
GO:0031532actin cytoskeleton reorganizationIMPbiological_process
GO:0030100regulation of endocytosisIDAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0008270zinc ion bindingIDAmolecular_function
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0016791phosphatase activityIEAmolecular_function
GO:0046875ephrin receptor bindingIPImolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0009966regulation of signal transductionIMPbiological_process
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process


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