Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL16_HUMAN
Description:interleukin 16 [Source:HGNC Symbol;Acc:5980]
Location:chr15 q25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S683GWRRAsPVTQTPhosphoSitePlus
S996SSQVSsAVMKSPhosphoSitePlus
S245LLRLLsTQAEEHPRD
S863GAQRLsLQPSSPhosphoSitePlus; HPRD
S480VKRLEsSWHGRPhosphoSitePlus
S705ARMDYsFDTTAPhosphoSitePlus
S835IRASSsSSSIRPhosphoSitePlus
S42LQPNAsLNEEECK2a1-rsRegPhos
S989TSKLYsISSQVPhosphoSitePlus
S844IRQRIsSFETFPhosphoSitePlus
T947LRLLStQAEESPhosphoSitePlus
S1320VIRRKsLQSKEPhosphoSitePlus
S952TQAEEsQGPVLPhosphoSitePlus
S851FETFGsSQLPDPhosphoSitePlus
S995ISSQVsSAVMKPhosphoSitePlus
S922PGVSEsPPPGRPhosphoSitePlus; HPRD
S144RQRISsFETFGErk1(MAPK3RegPhos
Y516SSDSSyMSGSPPhosphoSitePlus
S143IRQRIsSFETFRegPhos
S221PGVSEsPPPGRHPRD
S481KRLESsWHGRPPhosphoSitePlus
T56GHPDGtPPKLDCDK1HPRD
T933QPNQKtLPPGPPhosphoSitePlus
Y771GTPKVyKSADSPhosphoSitePlus
S219RDPGVsESPPPHPRD
T848ISSFEtFGSSQPhosphoSitePlus
S834HIRASsSSSSIPhosphoSitePlus
S961VLKMPsQRARSPhosphoSitePlus
S836RASSSsSSIRQPhosphoSitePlus
S572PPLPEsRDSHPPhosphoSitePlus
S743LQPNAsLNEEEPhosphoSitePlus
S331CITKDsSSFALPhosphoSitePlus
T757GHPDGtPPKLDCDK1HPRD
T56GHPDGtPPKLDCDC2RegPhos
S966SQRARsFPLTRPhosphoSitePlus
S743LQPNAsLNEEECSNK2A1HPRD
S743LQPNAsLNEEECSNK2A2HPRD
T631GHTPPtCGQEAPhosphoSitePlus
S42LQPNAsLNEEECSNK2A1HPRD
S42LQPNAsLNEEECSNK2A2HPRD
S144RQRISsFETFGErk2(MAPK1RegPhos
S972FPLTRsQSCETPhosphoSitePlus
S920RDPGVsESPPPPhosphoSitePlus; HPRD
S795AWFRQsLKGLRPhosphoSitePlus
S946LLRLLsTQAEEPhosphoSitePlus; HPRD
S833SHIRAsSSSSSPhosphoSitePlus
T757GHPDGtPPKLDPhosphoSitePlus
S144RQRISsFETFGMAPK3phosphoELM
S974LTRSQsCETKLPhosphoSitePlus
T970RSFPLtRSQSCPhosphoSitePlus
S42LQPNAsLNEEECK2a2RegPhos
S845RQRISsFETFGPhosphoSitePlus
S162GAQRLsLQPSSHPRD
S144RQRISsFETFGMAPK1phosphoELM
S42LQPNAsLNEEECK2a1RegPhos

Dephosphorylation site
IL16_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378147R485*BIOMARTBreast Cancer21930507, 21930502
ENSP00000378155A120ETCGAOvarian Cancer21720365, 18772890
ENSP00000378155Y239CBIOMARTBreast Cancer21930507, 21930502
ENSP00000378155H312QTCGAOvarian Cancer21720365, 18772890
ENSP00000302935T66PBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000378155R1186*BIOMARTBreast Cancer21930507, 21930502
ENSP00000378155R618GTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
IL16_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL16_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANIL16_HUMANkinase -> substrateRegPhos
CSK21_HUMANIL16_HUMANkinase -> substrateHPRD
CDK1_HUMANIL16_HUMANkinase -> substrateHPRD; RegPhos
CSK22_HUMANIL16_HUMANkinase -> substrateHPRD
MK01_HUMANIL16_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANIL16_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IL16_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030595leukocyte chemotaxisIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0050930induction of positive chemotaxisIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006955immune responseTASbiological_process
GO:0005125cytokine activityIEAmolecular_function


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