| UniProt/SwissProt ID: | BIK_HUMAN |
| Description: | BCL2-interacting killer (apoptosis-inducing) [Source:HGNC Symbol;Acc:1051] |
| Location: | chr22 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S35 | LGMTDsEEDLD | CK2_alpha | phosphoELM |
| T33 | EVLGMtDSEED | bcl-2I13 | PhosphoSitePlus |
| S35 | LGMTDsEEDLD | CK2a1(CK2 alpha | RegPhos |
| S35 | LGMTDsEEDLD | bcl-2I13 | PhosphoSitePlus |
| Dephosphorylation site |
| BIK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216115 | D10H | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| BIK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BIK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | BIK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BIK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008584 | male gonad development | IEA | biological_process |
| GO:0012505 | endomembrane system | IEA | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0051400 | BH domain binding | IEA | molecular_function |
| GO:0032464 | positive regulation of protein homooligomerization | IDA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0006917 | induction of apoptosis | IEA | biological_process |
| GO:0090200 | positive regulation of release of cytochrome c fro | IDA | biological_process |
| GO:0006917 | induction of apoptosis | TAS | biological_process |
| GO:0031966 | mitochondrial membrane | IEA | cellular_component |
| GO:0005740 | mitochondrial envelope | IEA | cellular_component |