Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BIK_HUMAN
Description:BCL2-interacting killer (apoptosis-inducing) [Source:HGNC Symbol;Acc:1051]
Location:chr22 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S35LGMTDsEEDLDCK2_alphaphosphoELM
T33EVLGMtDSEEDbcl-2I13PhosphoSitePlus
S35LGMTDsEEDLDCK2a1(CK2 alphaRegPhos
S35LGMTDsEEDLDbcl-2I13PhosphoSitePlus

Dephosphorylation site
BIK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216115D10HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
BIK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BIK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANBIK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
BIK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0008584male gonad developmentIEAbiological_process
GO:0012505endomembrane systemIEAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0051400BH domain bindingIEAmolecular_function
GO:0032464positive regulation of protein homooligomerizationIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0090200positive regulation of release of cytochrome c froIDAbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0031966mitochondrial membraneIEAcellular_component
GO:0005740mitochondrial envelopeIEAcellular_component


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